<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP00969

Description Mediator of RNA polymerase II transcription subunit 17
SequenceMPESKSISLLVPSELSSQQQNLQAQIQQIVSQKGHFRHVTEQSLRIDIQGKKSANDPLTADAPASAQDDKDDDETPQKHQERLWKRRDEMLERLSYAQNEVLCALDFVSLLISKQSVPAQSSMSPALKEAVPIGTLATHVLQNKAPSAALRKQLNLASQGWRSESFKFASEKLSKASTKLKAEAEKESKYWAQIADLTARGWPVSRLPRDAKAIGVHFGFPEATQQFRDRGFALLRQLDDGTVSLDIPRRRRRLGVSITRGNKTTGMFHFREIMKDQDTNIDQQITEARDSLFEEELFYEISREARSTANQGITTRGQHIEIALDAHSKLSLLFGEDNGSNESMSPQDNETAEFVGTSLRLLLNAMHEQNLARRSQRPPVMTLKPRPIPEYALIRPVIGHLRHRTQLSALLSYCNALIQPFAKAGLPITLETKEFSAEVFKSLKIESSAAILADLVLPAKTALELTLTGGRRMQIGLATFLGSPLYGSRFETSEVDFEFAIAPFSQHETFEAFTMFVRHALLLNLVAHIASLATKSATKTRNTDHRDSRNWKVSSPHIGELTLWEAGEAIKKIQVAVHAHSISVKLTPKPTHDAPKHIMWSWTTQGSSKADSSGVARAAGMKFDDVVINEILGQT
Length635
PositionHead
OrganismExophiala aquamarina CBS 119918
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Chaetothyriomycetidae> Chaetothyriales> Herpotrichiellaceae> Exophiala.
Aromaticity0.06
Grand average of hydropathy-0.409
Instability index55.03
Isoelectric point8.89
Molecular weight70717.48
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP00969
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     124.77|      41|     362|      24|      67|       1
---------------------------------------------------------------------------
   24-   67 (65.80/49.25)	AQIQQIVsqkGHFRHVTEQSLRID.....IQGKKSANDPLTADAPA.SAQ
  392-  438 (58.97/36.64)	ALIRPVI...GHLRHRTQLSALLSycnalIQPFAKAGLPITLETKEfSAE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     148.36|      51|     218|     104|     162|       2
---------------------------------------------------------------------------
  104-  162 (69.71/62.37)	ALDF...VSLLISKQSvPAQSSMSPALKEAVP.IGTlATHVLQNkapsaALRKQlNLASQGWR
  323-  377 (78.64/46.35)	ALDAhskLSLLFGEDN.GSNESMSPQDNETAEfVGT.SLRLLLN.....AMHEQ.NLARRSQR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      83.82|      26|     359|     175|     202|       3
---------------------------------------------------------------------------
  175-  202 (40.04/33.03)	KASTKLKAEAEKESKYW....AQIADLTArgW
  535-  564 (43.78/28.80)	KSATKTRNTDHRDSRNWkvssPHIGELTL..W
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP00969 with Med17 domain of Kingdom Fungi
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