<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP00967

Description Mediator of RNA polymerase II transcription subunit 19
SequenceMSSLPQSTTIPPSPTSPPAFGLKRRRLSDNIPQSPISPPLMSVATKSYVASYGNSHDTDEVSGRSSPRSPRGSVSRAHQPASRPTPSLPTPANSVVGIPGLEMTEDIDSHRDKRPRLDADRDEEEDKMQVDTNSLFTNHDRQQDAGPSDEADKRALQPDSLRGSKNEMNTLEQQKDMGEPFLLCRSKFEPQRPNPQQHLLAVYGLGPLLRSVARTDPLSGEKINKLRKSYEGQIKSFELPGRNKAVRGERNADEDQPGPLRRMAGSAPWGLQTDEQWNSEHARFNIEMTSDLHAKVKQAMQMQPGAVRNNTYWEGELGLSDKPKINPLPQRDQSSQPVLSRIPNGIPRSLPQAAGEPKRQTRGKKRSYGDDSFVGYGEGYSDGDFSGDDGYQKKRKKVI
Length399
PositionHead
OrganismExophiala aquamarina CBS 119918
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Chaetothyriomycetidae> Chaetothyriales> Herpotrichiellaceae> Exophiala.
Aromaticity0.05
Grand average of hydropathy-1.071
Instability index62.89
Isoelectric point9.07
Molecular weight44254.66
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364151

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP00967
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      84.84|      22|      25|     158|     182|       1
---------------------------------------------------------------------------
  108-  128 (28.90/12.99)	.DSHRDKRPR...LDADRDEE......EDKM
  132-  156 (22.54/ 8.75)	TNSLFTNH......DRQQDAGpsdeadKRAL
  158-  182 (33.40/23.25)	PDSLRGSKNEmntLEQQKDMG......EPFL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.76|      12|      20|       7|      18|       2
---------------------------------------------------------------------------
    7-   18 (26.00/10.49)	STTIPPSPTSPP
   28-   39 (25.76/10.34)	SDNIPQSPISPP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.27|      12|      17|      64|      75|       3
---------------------------------------------------------------------------
   64-   75 (21.50/ 9.38)	RSSPRSPRGSVS
   83-   94 (22.77/10.38)	RPTPSLPTPANS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      72.90|      21|     322|      42|      63|       5
---------------------------------------------------------------------------
   42-   63 (32.68/23.86)	SVATKSYVaSYGNSHDTDEVSG
  367-  387 (40.22/25.15)	SYGDDSFV.GYGEGYSDGDFSG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.62|      16|      20|     240|     255|       7
---------------------------------------------------------------------------
  240-  255 (28.15/15.76)	PGRNKAVRGER....NADED
  257-  276 (23.47/12.03)	PGPLRRMAGSApwglQTDEQ
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP00967 with Med19 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MSSLPQSTTIPPSPTSPPAFGLKRRRLSDNIPQSPISPPLMSVATKSYVASYGNSHDTDEVSGRSSPRSPRGSVSRAHQPASRPTPSLPTPANSVVGIPGLEMTEDIDSHRDKRPRLDADRDEEEDKMQVDTNSLFTNHDRQQDAGPSDEADKRALQPDSLRGSKNEMNTLEQQKDMGEPFLLCRSKFEPQRPNPQQHLLAVYGLG
2) SYEGQIKSFELPGRNKAVRGERNADEDQPGPLRRMAGSAPWGLQTDEQWNSEHARFNIEMTSDLHAKVKQAMQMQPGAVRNNTYWEGELGLSDKPKINPLPQRDQSSQPVLSRIPNGIPRSLPQAAGEPKRQTRGKKRSYGDDSF
1
229
206
373










Molecular Recognition Features






MoRF SequenceStartStop




1) FSGDDGYQKKRKKVI
2) PAFGLKRRRLSDNIPQ
3) SFVGYGEGYSD
385
18
372
399
33
382