<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP00963

Description Uncharacterized protein
SequenceMTSNPPAEPRPPSLKRPPDQLRPPHERHPSNPFLSAARAPQIQTQVVDNNVEDRPAKRRKVELTSATNQAAVTTNNANSTSIPTHYLVENQVPHFHLVQMSNVSPEIITQGGNNEQEKASDTEAPELPPRPWNTSQHSNVPDEPKPSHRSRVHIPVPTTPDSMKEPSCVPHFVMQRPAGFFPWTGKHPEDLLSDMTVKQGYFDKPPNPTEKELNTARVPLYNAFKHKSGVDNLSILFSLVLDQRNQHGLISSVSNFKPPPRVTLTEAKRKSWISDLANADVPLRRLSRTIPQGIRGQILLDQCLQHSVPLSRAIWFAKCVCANEIRTLKRKGTTPAVAIGAEYKWLREWTINVEQFIEAQLDQSRVPDWRSYIQYALRLVTRLYLENLLDRDHYLDWIVKSFGSAKVEAVPFWLMVIQIYKDDLTHFRKRGRKLAEAFLVRYDAIKKSAIPAETPLQQKLHQMLRGLLFSRPNSFLMPGKWPEYVAVVESCLDLDSPPERHILSQLNRINKRAMGYNRRELSSQRSPEQAVIEILDSAVAPYDVPVLGQTLASACGNTTLLISTCLGWAMTRFRHATSRIFLFARLVKRWQKAGHDVDSIILNYISACRSGKVSVDGAALKQLTAQLSRSGLFPVGKYIQWLMVRGLPEKGSITSQNLGIGIKPDSIATSNGSVDFDPAQLLLDISLQHVEDHTVNLRSSVLSRAGFDIEGEDRLVQGCRRAILQELRRRGPRLQAKSDGQDHPEPAFSRLPWTVRSAVSIWLRSQVAEAVAASAPSADAHAILTSHMMINCEQFYYIRHVLEALEDEAILADVIGILSCTRDEELLSSLVATLQYHGDAFSALGALEPLQRQICQIYMSWRATRPTMPHLATALLDLCTSFPIKVPSVKLLQQDLVRGDRGRAVAACSPYSDGIAESLQQAGATFIEDFEAILQSEPNMNEQTMNGMFTVLTDRIEKQQHVPEDGSTLFSFCQLLSRLKLCRKVQGDALVKKWFSRLVTALEGAFGTALVRDLVATGCLGFVSLFEALSLSKMDSRKSKPVRNILIEALGLSPNSREDPVIYHVRTKWWEYVGREPRAALEVLCDVGVKNELQASERMLLASLVSHDSTHSPLMSAQASEWAVKALDKLLLGSNGTKRGSDLRALFGSIDSFSHRFVQLRFSLNTPLTSGKATGPDGEELANGLFEALEQQVGGDAGVTGDVSRFSQLLQTVGTDAANQLRHKIEAEFLEALPKTPWNKVASPLTATFPSDVHHLASIVERAFQVCTPATTAMPGFMSQVIDKLSHHIKSVGTQVSPSGAPVIPGLSGCTASMSPAPGLNITSSPMPTPSENVPVAVPSWILEYLRCMLQMICLQRTGLILAGRSLNGKQAQQEQVQLLVRLALIASQPIFTSPTISFSGKDEQQTARGIREFILDVIATIVDEASDEVKLLSGKMLKDKLHRENRLVHLFGSVNGMGSVQTHDAGHGLLISKEGKGVLGDWKPRVWEVIDHGSGKESETSLGLGLFGARLG
Length1513
PositionKinase
OrganismExophiala aquamarina CBS 119918
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Chaetothyriomycetidae> Chaetothyriales> Herpotrichiellaceae> Exophiala.
Aromaticity0.06
Grand average of hydropathy-0.227
Instability index52.13
Isoelectric point8.62
Molecular weight167431.79
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.


Component of the srb8-11 complex. The srb8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The srb8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP00963
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.46|      16|      18|    1025|    1042|       1
---------------------------------------------------------------------------
 1025- 1042 (19.80/21.91)	LFEALSLSKmDSRKsKPV
 1046- 1061 (29.66/19.28)	LIEALGLSP.NSRE.DPV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.89|      12|      18|    1186|    1197|       2
---------------------------------------------------------------------------
 1186- 1197 (22.12/13.26)	FEALEQQVGGDA
 1206- 1217 (21.77/12.93)	FSQLLQTVGTDA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.29|      16|      42|     217|     233|       3
---------------------------------------------------------------------------
  217-  233 (24.03/17.18)	RVPLYNAfKHKSGVDNL
  261-  276 (26.27/13.93)	RVTLTEA.KRKSWISDL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.72|      15|      17|     597|     611|       4
---------------------------------------------------------------------------
  597-  611 (27.26/18.75)	VDSIILNYISA..CRSG
  615-  631 (20.45/12.14)	VDGAALKQLTAqlSRSG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.36|      14|      16|     288|     303|       7
---------------------------------------------------------------------------
  288-  303 (20.05/19.55)	RTIPqgIRGQILLDQC
  306-  319 (26.31/17.08)	HSVP..LSRAIWFAKC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      96.33|      23|      43|     353|     375|       8
---------------------------------------------------------------------------
  353-  375 (42.70/29.69)	VEQFIEAQLDQSRVPDWRSYIQ.Y
  381-  397 (21.98/11.45)	TRLYLENLLDRDHYLDW.......
  399-  420 (31.65/19.97)	VKSFGSAKVEA..VPFWLMVIQiY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      90.41|      20|      20|     972|     991|      11
---------------------------------------------------------------------------
  949-  968 (31.39/19.55)	FTVLTDRIEKQQHVPEDGST
  972-  991 (33.47/21.36)	FCQLLSRLKLCRKVQGDALV
  995- 1011 (25.55/14.48)	FSRLVTALE...GAFGTALV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     137.73|      43|     589|     678|     764|      12
---------------------------------------------------------------------------
  709-  763 (57.85/90.16)	IEGedrlVQGCRRAIlqelrRRGPRLQAKSdgQDHPEPAfSRLPWTVRSAVSIWL
 1304- 1346 (79.88/33.64)	IPG....LSGCTASM.....SPAPGLNITS..SPMPTPS.ENVPVAVPSWILEYL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      30.23|       8|      19|     179|     189|      13
---------------------------------------------------------------------------
  179-  189 (12.33/15.66)	GFFpwtGKHPE
  200-  207 (17.89/ 8.48)	GYF...DKPPN
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP00963 with Med12 domain of Kingdom Fungi
Unable to open file!