<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP00958

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMDQLDQINPNEGDFASEAFFNQGSLQQIQQPNGTSGLEAVGNVTLPTNPAVIQQLTRQWNSGCSDRVAWSRHGHIASISNDGTSVYLECLFFNRSSGAWDLTGRHTLTTIFEDAVSLAWSSTGGELIVVDTKGRTWVFHNSPVSINRLILVRQGRLDAVDEYSQLIGMAWLNQDRQDRPRNVVLHAAKNDSRWVHSNARAKPLGPYWHRAVAMVHRNGRLTICYQRGDMQYVKVTRQLGQSDDTLYTHAAFAPTVEGKMLVTLHACMGVISVYLVQFDWSEVKSNPEGQAALTIEAVSTCVSSLPTSSAALGGDAYDPDSWQLSHLEVVQTSDVEKAVQLSPVILAVSTGVNNSISIADPGYLVSSVIKKWAVTPVEQKLQSRFDDLPSKGANTSETSSIFTLERQPDKEEQVITTLRRIDGLHAVIITTQENRTDFLSSDDLSSVSYSASLTETTSMAQSGFAYPFTSTIHCPGFSPNACVRADVSPEGKTQIVGMEYQFQQVQLPQEPDPSTEVALASLNLSFARACWSNSTIDDILFCALRTVPPELIPTLVSGMYRTLFRDTEYIHEKTQGSELERVFHKQVMGKVMAYHAGLTAHCQGLITPATTGSGRCWPLTAQWAWLANNIRHTATILYMSLRDFQNLNTILSPEFTDMLCAQIKWGLGVVRFILNTILEVGDCESNPEIFMDEVGGTKPNNGAPAAGSGGIGRLGDTAGDGSQGLVALLLNCHWSRIFLIAFVRAVRAYAKVNEPKFRHQLQLLQCIQQQTNGKGISFQAIEAILEYRWAAVGDVEGNTAATATKQLQMMATGNVSEGYQGTVKALLSKLINSSAGLRAKMLIDRYRLFTDPVGLDYVFLNNEVIGCGGDADAVRFDIHRKRPILKGNIEDGGTGTGAGGGGTGLMVRKCGRCGSYSEDVNVPGREWPRQIASMMARCVCDGAWILEPWEAKV
Length952
PositionTail
OrganismExophiala aquamarina CBS 119918
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Chaetothyriomycetidae> Chaetothyriales> Herpotrichiellaceae> Exophiala.
Aromaticity0.08
Grand average of hydropathy-0.164
Instability index38.67
Isoelectric point5.82
Molecular weight104192.69
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP00958
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     126.50|      40|      48|      68|     115|       1
---------------------------------------------------------------------------
   72-  115 (63.86/50.68)	HGHIaSISNDGTSVYLECLFFNRSSG..AWDLTGRHTLttiFEDAV
  811-  852 (62.64/30.17)	TGNV.SEGYQGTVKALLSKLINSSAGlrAKMLIDRYRL...FTDPV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     148.52|      46|      48|     276|     321|       2
---------------------------------------------------------------------------
  276-  321 (79.59/55.61)	QFDWSEVKSNPEGQAALTIEAVSTCVSSLPTSSAALGGDAYDPDS....W
  322-  371 (68.93/47.10)	QLSHLEVVQTSDVEKAVQLSPVILAVSTGVNNSISIADPGYLVSSvikkW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     226.86|      65|     190|     665|     754|       3
---------------------------------------------------------------------------
    1-   39 (39.74/10.08)	MDQLDQINPNEGDFASeaffNQGSLQQIQQP..NGTSGLEA...........................................
  690-  754 (115.47/105.68)	MDEVGGTKPNNGAPAA....GSGGIGRLGDTAGDGSQGLVALLLNC...............HWSRIFLIAFVRAVRAYAKVNEP
  886-  947 (71.64/35.32)	...........GNIED....GGTGTG.....AGGGGTGL..MVRKCgrcgsysedvnvpgrEWPRQIASMMARCVCDGAWILEP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.08|      17|      20|     178|     197|       5
---------------------------------------------------------------------------
  178-  197 (26.14/23.29)	RPRNVVLHAAkndSRWVHSN
  201-  217 (32.94/20.04)	KPLGPYWHRA...VAMVHRN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.29|      16|     125|     463|     478|       6
---------------------------------------------------------------------------
  463-  478 (34.22/20.31)	FAYPFTSTIHCPGF.SP
  591-  607 (28.07/15.46)	MAYHAGLTAHCQGLiTP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.12|      19|     186|     665|     683|       8
---------------------------------------------------------------------------
  665-  683 (34.35/27.93)	GLGVVRFILNTILE.....VGDCE
  772-  795 (26.78/19.87)	GKGISFQAIEAILEyrwaaVGDVE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      89.32|      29|      55|     372|     400|       9
---------------------------------------------------------------------------
  372-  400 (49.91/31.60)	AVTPVEQKLQSRF...DDLP..SKGANTSETSSI
  425-  458 (39.41/23.51)	AVIITTQENRTDFlssDDLSsvSYSASLTETTSM
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP00958 with Med16 domain of Kingdom Fungi
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