<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP00952

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMAAALDFPSNCATNVYTLNDFGEIAYIVCTVANPPIRDPSVTSNTRENTVARLRRTERQFREASILAALDVDALQLFTFYKKIDIANAKDQKTLLSKFGFVLRSNTCTIAYKTAARLADLMKPDQGRLYRLFTTAIISSLRLSPSTECEVQSLGPNLYLIEYLPPASDVHEFESPRRWVLFRVDLQVILSGHIILTIASNDNLSFVRLREALRHGDYAPRTTKCMTLYLAPIGSVARLTGPNLARLYSRIQDGLEAPGHEISSMEEDAWKEMLPWWLRDQMNYTNDPKNVPWVEVQIPIQKADMTWDDSSLDSSPDSLTFESISWKSIFWPANLCFIWDREKGTPRGAIHNIEDPLQFVQTWITGAAGGPVTDMSQNHQNAFEDDEEPLFTEDGTFDDPEHFQPFGPPAFAASQTIYPTPPDVIMTHTTPGLSVDCIPVTPGNIARENAELPQLQDEEMPDFEVPHSSGAGPGYYDEDLFEEMPDDNFGQEGTGDEPNWDFFDQPGMDSKDVPLGAPRQINENPVDGVVGHDVGASRTKITEDFDLSPTDQRSKNEDLEAMVADKKSSKTLGQGGNWSHSTSIIGGDSRALQPVQSRSPDHHVASDEPAQKSTPQDKATRRRSSVYDGLQSVAVASDRDSRYTSNGAYWFDPSPALTNPKAVKKQNAIYQIIPTSPSGSDGSSMSSRPMSLDHGNTNMWTPGLPRQWTEYHVESPIEQNLHNDVEKAAIQRDIQKVLNSLPTGLKVPPSTLDFNLVKQIREIPGISTQKFLQVAHILVDQVSQTCLVRHTGDPPGHEPIPDDHSYVHADLSGMNTSASSSSLHQLVNLRVDNNQSRPQGRILKLFSPQIHVRRAEQPLTASTSILGFWDVLNLQPEHGAKDVTAFCIHPNAQTVADGCSNFMQRMKDAYSACALGNHHPGSIAGLTNDDGLLAWATNEPHQANLRSICKRLGDALSAASDLKGMIVVYMTSQSDRMTDYLETCYAFYTLFETFAQSSTDKKNVVDIALQIIPLDFVADGQTLIIPPQSDYIKLALEVYNRLPPPHPEAAPGTCGSAVSVAVAETSVHFRLNTEVSSPLFKHGRLLHVSYSISDDDRWITAAWTDECGKLALTMSYCTQIWRSSPRRQRRDIFKEIWEVSHDLIGKEQGAWRLCVAKTDSYDSDELGEWRHVVDGNPTSKKRCTLVLLSVRLHPLLKLIPPFTQGRNGPMGGPNTYGTPASTPQTSITSPDQLVPATPTPGGSGIVSAPTPPEHGYDPNVESDLTLVDPAEESWSIVLPYGINQTSNVVELRPSMLTGLLMKRKGVKGEDGHASIEVSLFNLIPSAPATEEPWMDELLEDIIKQYRGLVTLSVTRGCIDAGLDCLPWHVATSIRGARVLGEVM
Length1382
PositionKinase
OrganismExophiala aquamarina CBS 119918
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Chaetothyriomycetidae> Chaetothyriales> Herpotrichiellaceae> Exophiala.
Aromaticity0.07
Grand average of hydropathy-0.393
Instability index47.72
Isoelectric point5.08
Molecular weight152736.74
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP00952
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      37.40|      10|      29|     755|     764|       1
---------------------------------------------------------------------------
  755-  764 (17.58/ 9.90)	LVKQIREIPG
  786-  795 (19.82/12.28)	LVRHTGDPPG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     117.66|      33|     528|     659|     751|       2
---------------------------------------------------------------------------
  670-  707 (55.32/34.14)	QIIPTSPSgSDGSSMSSRPMSLDHGntnmWTPGLPRQW
 1231- 1263 (62.34/25.04)	QLVPATPT.PGGSGIVSAPTPPEHG....YDPNVESDL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      92.12|      18|      84|     382|     406|       4
---------------------------------------------------------------------------
  382-  399 (32.19/11.80)	FEDDEEPLFTEDGTFDDP
  480-  497 (32.04/11.68)	FEEMPDDNFGQEGTGDEP
  507-  524 (27.89/16.47)	MDSKDVPLGAPRQINENP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      89.06|      26|     126|     899|     940|       6
---------------------------------------------------------------------------
  247-  275 (39.49/13.48)	YSRIQDGLEAPGhEISSMEEDawKEMLPW
  909-  934 (49.57/31.26)	YSACALGNHHPG.SIAGLTND..DGLLAW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      72.31|      22|     797|      54|      75|       9
---------------------------------------------------------------------------
   54-   75 (36.90/24.74)	RRTERQFREA.SILAALDVDALQ
  852-  874 (35.41/23.43)	RRAEQPLTAStSILGFWDVLNLQ
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP00952 with Med13 domain of Kingdom Fungi
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