<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP00918

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMAELGQQTVDFSTLVARAAEESYVSLKELVEKSKGSDISDSEKKIGILKYVVKTQQRMLRLNVLAKWCQQVPLVQYCQQLESTLSSHDTCFSQAADSMFFMHEGLQQARAPIYDVPSAVEVLLNGTYHRLPKCIEDVGTQSTLNVDQQKPALMKLDALVRSKLLEVSLPKDITEVKISDGTVLLRVDGEFKVLVTLGYRGHLSLWRILHLELLVGERSGPVKLEELQRHALGDDLERRMAAAENAFMTLYSILHELCVALVMDTVIRQVQALRQGRWKDAIKFELISDGSMGQGGNAGGTQITQDGEADAAGLRTPGLKILYWLDFDKTSSTPDVGSCPFIKIEPGPDLQIKCLHSSFVIDPVTGKEAEFSLDQSCIDVEKLLLRAICCNRYTCLLEIFKELEKNNQIVRAPGDVRLETQMDKFDNDGKKDISKFDSRKDEGQEVLLVRAYGLSFFTLGINLRNGHFLLHSSKNTVSPSELLECEEALNQRTMTAAQVFISLRSKSISHLFACVGRSLGLEVFERGFASLKLPKNISNGSSVLLMSFPECGSSYYLLMQLDKDFKPLFNLMETQPDPSGKAESFSDLNNIIRVKDVDIGQMQMCEDDLNLSLLDCGKLLSVLPSLSPNRTSEQSLLSEFTLEGSALASSFPSKFSSIVDEVFELEKGSSAANLSGHGPSLGSTYGTSPASHFGAGGMNLHSTKVGTPSPKWDGGSQVPTRLSGMPPSYSGSIYTGSHYRGLIQSGSTGSISVGPGRSQVKNLSSSKSDQDLTSLRSPQSGGLGSYSLIDEHQVTTPGIRTAGHLSPSPQLGLPASGASAKPIGARNSSGNAIPGNLRVSGFNSLVASPVSQTPDSNYMNSNLDTVPRQEKMSRKRTLTDLLSSLPSLQHPEANDKSYKRRRIVEWRPQQLTSQMLITSELFRKTEGYSYGDLISEANKGNLPSSIYVSALLHVVRHCSLCIKHARLTSQMDALDIPYVEEVGLRSASSNLWFRLPFARGDTWQHICLRLGRPGSMYWDVKICDQHFRDLWELQKGMSNSPWGPGVRIANTSDVDAHIRYDAEGVVLSYHSVEADSIRKLVADIERLSNARTFALGMQSLLGVRTDEKFEENATASDVKAPGGVKTVLDMADKFSEQMRRAFKIEAVGLMSLWFSFGSGVLARFVVEWESGKEGCTMHVSPDQLWPHTKFLEDFINGAEVASLLDCIRLTAGPLQALAAATRPARAAPVSGVSGVAAPISSMSRQSGYVPSQGQLPSIATPNASQAASVPAGNASASVTSGPLASQNPHTTAMLAAAAAAAAGRGGPGIVPSSLLPIDVSVVLRGPYWIRIIYRKNFAVDMRCFAGDQVWLQPATPPKGGPSVGGSLPCPQFRPFIMEHVAQELNGIDSSFAGGQQTVVLANGSSSNPSTVSHLSASNGNRTNLANSAGISRSANAVSGLNRMGNVVPAGSNLAAANSGLPLRRSPGTGVPAHVRGELNTAIIGLGDDGGYGGGWVPLVALKKVLRGILKYLGVLWLFAQLPELLKEILGSILKDNEGALLNLDQEQPALRFFIGGYVFAVSVHRVQLLLQVISVTRFHHSQRQQQNSATAQDELTPSEISEICDYFSRRVASEPYDASRVASFITLLTLPISVLREFLKLIAWKKGLAPSPGGDLAPAQKSRIELCLENHAGFTMDGKNESSSVSKSNIHYDRAHNAVDFALTVVLDPAHIPHINAAGGAAWLPYCVSVRLRYSFGDNPNVSFLGMEGSHGGRACWLRVDEWEKCKQRVTRTVEVNGSSAGDGNQGKTGCN
Length1791
PositionTail
OrganismCoffea canephora (Robusta coffee)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> asterids> lamiids> Gentianales> Rubiaceae> Ixoroideae> Gardenieae complex> Bertiereae - Coffeeae clade> Coffeeae> Coffea.
Aromaticity0.07
Grand average of hydropathy-0.166
Instability index44.90
Isoelectric point6.90
Molecular weight193972.31
Publications
PubMed=25190796

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP00918
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     136.14|      34|      34|     802|     835|       1
---------------------------------------------------------------------------
  802-  825 (33.21/16.36)	..............GHLSP...S..PQLGLPASGA...SAKPIGAR
  826-  857 (40.69/22.19)	NSSGNAIPGN.........lrvS..GFNSLVASPV...SQTPDSNY
 1404- 1439 (30.20/14.02)	SSN....PST...vSHLSA...SngNRTNLANSAGisrSANAVSGL
 1440- 1471 (32.04/15.45)	NRMGNVVPAGsnlaAANSG...L..PLRRSPGTGV...PA......
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      86.26|      27|      45|    1210|    1240|       2
---------------------------------------------------------------------------
 1210- 1240 (38.84/32.55)	AGPlQALAAATRPARAAPVSGVSGvaaPISS
 1258- 1284 (47.42/27.32)	ATP.NASQAASVPAGNASASVTSG...PLAS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     139.85|      41|     546|      85|     131|       3
---------------------------------------------------------------------------
   85-  131 (67.74/52.24)	SSHDTCFSQAADSMFFMHEGLQQARAPIYDvPSavevlLNGTYHRLP
  648-  688 (72.12/41.86)	SSFPSKFSSIVDEVFELEKGSSAANLSGHG.PS.....LGSTYGTSP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      84.50|      29|      49|    1071|    1099|       4
---------------------------------------------------------------------------
 1071- 1099 (48.36/32.08)	VEADSIRKLVADI.ERLSNA..RTF...ALGMQSL
 1117- 1151 (36.14/22.08)	VKAPGGVKTVLDMaDKFSEQmrRAFkieAVGLMSL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     270.15|     106|     609|     903|    1054|       5
---------------------------------------------------------------------------
  502-  562 (62.03/18.63)	LRSKSI..SHLF.ACVGRSLGLEVFE..RGfaslKLPKNISngSSVLLMSFPECG...SSYYLLMQLDK..................................................................................
  910- 1054 (146.82/169.17)	LTSQMLitSELFrKTEGYSYGDLISEanKG....NLPSSIY..VSALLHVVRHCSlciKHARLTSQMDAldipyveevglrsassnlwfrlPFARGDTWQHICLrLGRPGSMYwdvkicdQHFRDLWELQKGMSNSPwGPGVRIANTSDVD
 1614- 1664 (61.30/20.89)	...........................................................................................PYDASRVASFITL.LTLPISVL.......REFLKLIAWKKGLAPSP.GGDLAPAQKSRIE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     154.64|      33|      47|     701|     743|       6
---------------------------------------------------------------------------
  701-  733 (57.54/24.18)	STKVGTPSPKWDG..GSQVPTRLSGMPPSYSGSIY
  751-  782 (45.09/30.10)	SVGPGRSQVKNLS..SSKSDQDLTSLRSPQSGGL.
 1361- 1395 (52.01/20.57)	SVGGSLPCPQFRPfiMEHVAQELNGIDSSFAGGQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.74|      17|     259|     618|     634|       7
---------------------------------------------------------------------------
  618-  634 (29.42/15.48)	LLSVLPSLSPNRTSEQS
  880-  896 (30.32/16.18)	LLSSLPSLQHPEANDKS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      38.67|      10|    1355|     143|     152|       9
---------------------------------------------------------------------------
  143-  152 (19.33/11.16)	LNVDQQKPAL
 1540- 1549 (19.34/11.17)	LNLDQEQPAL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP00918 with Med14 domain of Kingdom Viridiplantae
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