<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP00884

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMQPISQTSDKEGLMETNGHATTTATTTASPSQQDGVNGKSVISKAVDPTPSQNGNVEKIALQNEMASMVPLQVLIGKMVNKTYADLQTLTDTLSSRGEVEKKRQILKYVTFVQNQMLKLSVLVKWAENADDIQMCQNIMAFLANQNQFFHDATRFLNKIHVELPRARIRNFDIPTAVDVLTTGSYQRMPSKFKDMVPKSPLTDEEVLETFRKMNDVIRMRMLTTEVLPSPMQHYRIESGRITFTIKDEFEVSLTLMGPPSEQRWWIVSLDIQVKSTVGSGAADVDISLNEIQRQYLRVNAQKQLVPPQPPQDEQTKTPLFFPLVNLHDYLHLFCLNMQLEIIYMQSTMVSKTRWLEQLKVQMDPTRNKLVLVYWKGGSPTAHWAHPQLELAGRPLENSTTIEISVVDEKSKRKGPYSDQINMAISVRDDMRGLVQRAGLGASAMLSAVDDEDKPAVVSALQYPKNQLEVLWGGFNNLHADKELLNPSDLNIERVLWHVTRHHSTCIIKRFRSLLKEQEQFLNDNGLHLIEGSLENVLSGVDRVTETKDDMEHDEQGIPSIAIRYRHRRYITITMDVRTGRVKVRELGYKLGEGDAKLKELEERLNSDPENIARHLLWLRSEVVIREIVSLAKQLSLQPFSPSQMSLRPDDFIKLFGDLPTSHTPSEPATSTTSATTAAQPTTAAAAAASRRPALYPSHCVFLQFVQFEDWYLVIAIVRNEVYSWLCCINKTYDQNGLFQVIVDMMHVEYEEMWKEHFLPKLDEDTDRDTSSKRRRSSVEQEQDTQSTLQHVTRKRRRTEASLEDTSQQESTTEIIDNLSVNLRFMAKLDSLCRACITNCKIELQLQRLRGSINFTSRPLLKSLPTAESQVLNHPAAKKMEVLCVPQRDLLKACVMRNVDESHPTANNREVPLHIRPWVEKMIPEMKNDVVMRASGWWACGRSECFVVIQEKFDWKNMPLPTHDIRDHISLDKVSNVLSFTYTDIDNCIDRFLVDWERIFMMSYLARQSSSKWMDRYKDQLKFESFDTHGLRFTYAKDLSCSVRWDSPSRGRARQYVISLGMMENGEHPKPKDKESATSLHMYTQNPHWRVTPFLQDILNEKRDLVYLVQIMVQTLPFMACLEKLEVDIAQKGAIGDISIIPHGADSVRIVFSSTHALDIRFTDHKTLCISDVAFQHLFYSSLALANTQGKGVAATAKSTEASENKKENNDDNEKEGTMKPIKVAQSFNFEPFTKFDELLESVDDWLFVGNNDDEPKQDPWYSFMDEEEPTAVPFHHGLLCSASLCRRVIGQLGTLV
Length1296
PositionTail
OrganismLichtheimia corymbifera JMRC:FSU:9682
KingdomFungi
LineageEukaryota> Fungi> Fungi incertae sedis> Mucoromycota> Mucoromycotina> Mucoromycetes> Mucorales> Lichtheimiaceae> Lichtheimia.
Aromaticity0.07
Grand average of hydropathy-0.425
Instability index46.50
Isoelectric point6.06
Molecular weight148140.37
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP00884
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      74.96|      25|      40|     857|     885|       1
---------------------------------------------------------------------------
  857-  885 (41.21/35.72)	RPLLK.........SLPTAES.QVLNH..PAAKKMevlcVP
  887-  923 (33.75/19.21)	RDLLKacvmrnvdeSHPTANNrEVPLHirPWVEKM....IP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      83.03|      21|      40|      38|      58|       2
---------------------------------------------------------------------------
   18-   36 (22.24/11.48)	GHATTTATTT.....ASPSQQDGV..
   38-   58 (34.31/22.06)	GKSVISKAVD.....PTPSQNGNVEK
   76-  101 (26.48/15.20)	GKMVNKTYADlqtltDTLSSRGEVEK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     113.95|      34|      40|     950|     983|       4
---------------------------------------------------------------------------
  950-  983 (61.60/40.68)	EKF..DWKNMPLPTHDIRDHIS..LDKVSNVLSFTYTD
  989- 1026 (52.35/33.42)	DRFlvDWERIFMMSYLARQSSSkwMDRYKDQLKFESFD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      68.20|      23|      27|     336|     359|       6
---------------------------------------------------------------------------
  336-  359 (35.24/25.49)	NMQ.....LEIIYMQSTmVSKTRWLE.QLK
  361-  389 (32.96/18.52)	QMDptrnkLVLVYWKGG.SPTAHWAHpQLE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      86.86|      29|     591|     144|     190|       7
---------------------------------------------------------------------------
  144-  181 (37.10/48.13)	NQNQFFHDatrflNKIHveLPRARIRNfdIPTAVDVLT
  516-  544 (49.75/35.77)	EQEQFLND.....NGLH..LIEGSLEN..VLSGVDRVT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      69.11|      21|      41|     746|     770|       9
---------------------------------------------------------------------------
  746-  770 (33.88/32.90)	HVEYEEMWKEHFLpkldEDTDRDTS
  790-  810 (35.22/22.51)	HVTRKRRRTEASL....EDTSQQES
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      71.80|      18|      43|     391|     409|      10
---------------------------------------------------------------------------
  391-  409 (25.47/22.81)	AGrPLENSTTIEISVVDEK
  415-  430 (22.44/13.27)	...PYSDQINMAISVRDDM
  437-  451 (23.90/15.10)	AG..LGASAM..LSAVDDE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.29|      11|      27|     228|     238|      11
---------------------------------------------------------------------------
  228-  238 (21.90/ 9.57)	PSPMQHYRIES
  258-  268 (23.39/10.64)	PPSEQRWWIVS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      70.98|      20|     758|     293|     327|      13
---------------------------------------------------------------------------
  185-  205 (33.19/ 8.43)	YQRMPSKfKDMVPKSPLTDEE
  295-  314 (37.79/31.08)	YLRVNAQ.KQLVPPQPPQDEQ
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP00884 with Med14 domain of Kingdom Fungi
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