<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP00876

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMVELAPKKRRRLDSTTTTTTPSYASARYPPSCLLSNLIHRQAPHQLSSSIQSVVVTTPPKPATPAIHAFTGDHYALDLVSKSTTLLNKSPIRLAEQFHDQCLITHLVWNQRGTTLASADENGKIALWELGTSSDQWTLAYSVNLQQPPAGILWLNTDRVYQLSHDQQKFVRMPMVGPRNPYGYFAFVVVTVHGQVSVHYQRGGKIFSSFSTTLPNTGRMGAGRADVGCFGMNLASSDNWYRISHASMIIGQDGNIYLATHRANTSPKSVQIYRLSIRFPGRMNEGGIFCQPLATLRLTQPSLASSLGDFAKSSSIAVSHLQLSNQKDNVQLTLAFGAENDGSYSSFIGKWALQQKEIQISGDAIARDSFSGTTMTSNYLVLDFVDGVSVSDRFISSMTHTRHGALVVGLSDGSVHIEYRDDGDFGLLRGRGSCESSIGPTFWQAAGPRTYLNGDPDPVAGLALSPNETHIFCILSSNKLGVIRATDIRNDHDETETLSTISRLLKLSLLNETDDLDLISELIRVNAISGHDDATESLVLDVIKSYHVYCHQDQSEPLLVSPTTESSSKSSGSLEWSLPQRGRAYGLSLGVFRRLSSTKVQYTNLCKAIQLPIVLECFIGSCKSDYADITKVLDSNTIVDGKATLEFDTDSLWSLMSLTNWTLDFMRWTLRKWNMLFNCRRPKDSKLGDISARPCHAVLLLHEESRDALSKLLVMVNEFVHYTNSASFELPNVPESLPLLLRYAKNVLSSEPVALKDVLAFLTAIKSEDLGVQDRWALLLGSKLPSDKVDRLRVITREFAEKCGQPAIYLERDSSDIIDVIQKRRIPPFTKHLWTCVRCHQYSIPTHGHPHLTANDPCLRALWNRSIGRRCVCGGLFAECL
Length880
PositionTail
OrganismLichtheimia corymbifera JMRC:FSU:9682
KingdomFungi
LineageEukaryota> Fungi> Fungi incertae sedis> Mucoromycota> Mucoromycotina> Mucoromycetes> Mucorales> Lichtheimiaceae> Lichtheimia.
Aromaticity0.08
Grand average of hydropathy-0.184
Instability index42.60
Isoelectric point7.82
Molecular weight97541.80
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP00876
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     178.73|      60|     180|     258|     331|       1
---------------------------------------------------------------------------
  263-  331 (84.30/77.77)	NTSPKSVQIYRLSirfPgrmNEGGIFC....QPLATLRLTQpsLASSLGDFAKSSSIAvSHLQLS..NQKDNVQL
  452-  517 (94.43/50.27)	NGDPDPVAGLALS...P...NETHIFCilssNKLGVIRATD..IRNDHDETETLSTIS.RLLKLSllNETDDLDL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     132.54|      38|     287|     547|     586|       2
---------------------------------------------------------------------------
  547-  586 (60.72/47.42)	VYCHQdQSEPLLVSPTTESSSKSSGSLeW..SLPQRGRAYGL
  836-  875 (71.82/46.40)	VRCHQ.YSIPTHGHPHLTANDPCLRAL.WnrSIGRRCVCGGL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     162.45|      48|     194|     137|     231|       3
---------------------------------------------------------------------------
   20-   69 (81.64/33.25)	TPSYA.SARYPPSCLLsnLIHRQAPHQLSSSIQSVVVTTPPKPATP.AIHAF
  137-  186 (80.81/115.90)	TLAYSvNLQQPPAGIL..WLNTDRVYQLSHDQQKFVRMPMVGPRNPyGYFAF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     114.56|      36|      38|     705|     740|       6
---------------------------------------------------------------------------
  705-  740 (58.52/35.15)	RDALSKLLVMVNEFVHYTNSASFELPNVPESLPLLL
  744-  779 (56.04/33.39)	KNVLSSEPVALKDVLAFLTAIKSEDLGVQDRWALLL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.80|      20|      32|      81|     100|      10
---------------------------------------------------------------------------
   81-  100 (34.76/21.10)	KSTTLLN...KSPIRLAE..QFHDQ
  111-  135 (25.04/13.32)	RGTTLASadeNGKIALWElgTSSDQ
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP00876 with Med16 domain of Kingdom Fungi
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