<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP00875

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMVELAPKKRRRLDSTTTTTTPSYASARYPPSCLLSNLIHRQAPHQLSSSIQSVVVTTPPKPATPAIHAFTGDHYALDLVSKSTTLLNKSPIRLAEQFHDQCLITHLVWNQRGTTLASADENGKIALWELGTSSDQWTLAYSVNLQQPPAGILWLNTDRVYQLSHDQQKFVRMPMVGPRNPYGYFAFVVVTVHGQVSVHYQRGGKIFSSFSTTLPNTGRMGAGRADVGCFGMNLASSDNWYRISHASMIIGQDGNIYLATHRANTSPKSVQIYRLSIRFPGRMNEGGIFCQPLATLRLTQPSLASSLGDFAKSSSIAVSHLQLSNQKDNVQLTLAFGAENDGSYSSFIGKWALQQKEIQISGDAIARDSFSGTTMTSNYLVLDFVDGVSVSDRFISSMTHTRHGALVVGLSDGSVHIEYRDDGDFGLLRGRGSCESSIGPTFWQAAGPRTYLNGDPDPVAGLALSPNETHIFCILSSNKLGVIRATDIRNDHDETETLSTISRLLKLSLLNETDDLDLISELIRVNAISGHDDATESLVLDVIKSYHVYCHQDQSEPLLVSPTTESSSKSSGSLEWSLPQRGRAYGLSLGVFRLSSTKVQYTNLCKAIQLPIVLECFIGSCKSDYADITKVLDSNTIVDGKATLEFDTDSLWSLMSLTNWTLDFMRWTLRKWNMLFNCRRPKDSKLGDISARPCHAVLLLHEESRDALSKLLVMVNEFVHYTNSASFELPNVPESLPLLLRYAKNVLSSEPVALKDVLAFLTAIKSEDLGVQDRWALLLGSKLPSDKVDRLRVITREFAEKCGQPAIYLERDSSDIIDVIQKRRIPPFTKHLWTCVRCHQYSIPTHGHPHLTANDPCLRALWNRSIGRRCVCGGLFAECL
Length879
PositionTail
OrganismLichtheimia corymbifera JMRC:FSU:9682
KingdomFungi
LineageEukaryota> Fungi> Fungi incertae sedis> Mucoromycota> Mucoromycotina> Mucoromycetes> Mucorales> Lichtheimiaceae> Lichtheimia.
Aromaticity0.08
Grand average of hydropathy-0.179
Instability index41.99
Isoelectric point7.58
Molecular weight97385.61
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP00875
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     178.46|      60|     180|     258|     331|       1
---------------------------------------------------------------------------
  263-  331 (84.00/71.48)	NTSPKSVQIYRLSirfPgrmNEGGIFC....QPLATLRLTqpSLASSLGDFAKSSSIAvSHLQLS..NQKDNVQL
  452-  517 (94.45/46.26)	NGDPDPVAGLALS...P...NETHIFCilssNKLGVIRAT..DIRNDHDETETLSTIS.RLLKLSllNETDDLDL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     132.54|      38|     287|     547|     586|       3
---------------------------------------------------------------------------
  547-  586 (60.72/47.31)	VYCHQdQSEPLLVSPTTESSSKSSGSLeW..SLPQRGRAYGL
  835-  874 (71.82/46.30)	VRCHQ.YSIPTHGHPHLTANDPCLRAL.WnrSIGRRCVCGGL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      93.30|      29|      32|      81|     111|       6
---------------------------------------------------------------------------
   83-  111 (52.64/35.88)	TTLLN...KSPIRLAE..QFHDQCLITHLVWNQR
  113-  146 (40.66/20.41)	TTLASadeNGKIALWElgTSSDQWTLAYSVNLQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.97|      20|      37|       5|      24|       7
---------------------------------------------------------------------------
    5-   24 (34.80/21.80)	APKK.RRRLDSTTTTTTPSYA
   42-   62 (31.17/18.80)	APHQlSSSIQSVVVTTPPKPA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.03|      14|      20|     741|     760|       9
---------------------------------------------------------------------------
  747-  760 (22.47/23.10)	SSEPVALKDVLAFL
  764-  777 (24.56/ 9.30)	KSEDLGVQDRWALL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP00875 with Med16 domain of Kingdom Fungi
Unable to open file!