<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP00867

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMVTDASLTNIFVVNGVSHIRYRAYTSTCQRSTLLSCLKTQASGSNPLIQANHDLCQLNIPCTWRMTPRVNQSGDALSLELWVFWFEDRHTGIIDANQYLTELEEIKMGSFTWDKIISSKGGATSSPSPNGKASQQPRAKSLVSLPEEYKLFIKSVRNLVNRAMLSKGAIPLGDFFILQHHDTDTGLFQGSLPASITSTMVGCAYNTYVTGTDLVFRPYTRQLRIRALVNEDLDNYGLKVILSPSGEQACLTSYVSEISEQVQDETIREWSSLYNIPIQHLTAPYTSQPTQALPSLVAIRTKTNATALYPAKLVFVPTSTRQSSARMAGMDGVFSCDRGLTRDIGKDWNRWSWINEMNQSSSNNNTNMSPQDGCRIDYWSLDDSAGRIMDALAAGNPMHEFAVLKKALDQPPVPAVRSKAAASRRSSAHGTATSTTTAVDGTQNDSLLDFIMRNFSNPADEDTPMTMESALEDSATSAPYTVTPTDQHPEETPVISQDIAATDDAFGLGYSNNMFGTERWDNDMDDDFDNFDFDVTEADFDFFKSEKKQQQQQQPSCSMMELDKPEPVNDSMNVSTAAPTTTDIVIPDTIKSEPFDLSAQPVAPTPAEEITHPPQQAQSSASPMVCDTTPVASSDAGISTTAPGTVDMSICTTPDIRQHTYQQSIPHVVTTSKPGYAMDNLNMIPKDFSAVAFPMGVDDAKYMGGGKFDYKSPSNDIGASETADQDVKLNRYRPDYVPPKILVDEAKREEEDKNNIGDGKNEDDDDDDDASETGSTSTNTSSSDESDQSDASSSDVSLSSHGDEQSGNVLERIQSAQMTYIRRLLGDIKNRPKRHRVGNLVMDYDSPFPTSIMDTIQPEKMNPDDIASLDQLCQQAVWGGYPFAGELPESMSASSDGVCAREDAATIVTRQTTLIQSIRGDITHVPSLPSTCVRVVQGFKSLLEEVFSQQTPDGATPADVPDAMDSPSTTASTLVGGVSIKGPLKVQEYYQLLETTPTQSRYYGKFQVKKKRSTEPDLQSLGPPDIVVGRSDDWLEGSPEMIHVWEKIKLEPYSFKNNIRYFVLYPDNQEMSKAISTFIANLSCAYEVCNLGTHLPGRAEPFTGGIAAVPLHANTSWTTAYSDACEKLGTTLGMTNMLAQERNTTNIVIYLINPSTQLSSNLALSRAFRTLVSAYTAVYRRFGRATIHPRALAMQIIPAEHVLRMGESFTMPVFKDIAFSVYSQCHSTLQRTKKVDSTRSHSLLYTPPWVIAQRVPDTIRFSFKRPLVPYPTVIVDSDAMLHMVYSFSLDRRWMITVWSDHRGELIEFAVLEIQAAVIAGKPNGSPLVQVFAEAWSRTKKLAHRTGFSWQYAIAKMGLIFESELQAWEDVLCSAGDNDEKVAIVCIDIDSPLTIDMFLSNTNNSLSAEELTAQAMSQLSERYTYSSSASSSPAPTDSPRSKENKTKSQPAMDPSTLLILLNHRMAYSRQRVNIYQGDLSMESMNELDRWMLPLSSGYLIKQNSSQEAAVSCRQPSILELHLVYNKQSRNARLALREIMKQYNALSYVNHPPSHARMHASMLPNHLVLVERLTRILLVVGS
Length1579
PositionKinase
OrganismLichtheimia corymbifera JMRC:FSU:9682
KingdomFungi
LineageEukaryota> Fungi> Fungi incertae sedis> Mucoromycota> Mucoromycotina> Mucoromycetes> Mucorales> Lichtheimiaceae> Lichtheimia.
Aromaticity0.07
Grand average of hydropathy-0.390
Instability index48.71
Isoelectric point5.09
Molecular weight174607.04
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



ECO:0000256	RuleBase:RU364134

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP00867
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     393.32|     128|     193|     409|     601|       1
---------------------------------------------------------------------------
  459-  601 (200.29/156.84)	DEDTPMTMESALEDSATSAP.YTVtptdqhpEETPVISQDIAATddAFGLGYSNNMF.GTERWD.....NDMDDDfDNFDFDVT....EADF...DFFKSEKKQQQQQQPSCSMmelDKPEPVNDSMNVSTAAPTTTDIVIPDtiKSEPFDLSAQPV
  654-  795 (193.04/76.70)	DIRQHTYQQSIPHVVTTSKPgYAM.......DNLNMIPKDFSAV..AFPMGVDDAKYmGGGKFDykspsNDIGAS.ETADQDVKlnryRPDYvppKILVDEAKREEEDKNNIGD...GKNEDDDDDDDASETGSTSTNTSSSD..ESDQSDASSSDV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      75.30|      24|      65|     360|     388|       2
---------------------------------------------------------------------------
  360-  388 (36.78/38.83)	SSNNNTNMSPQ...DGCRIDywSLDDsagRIM
  425-  451 (38.52/22.72)	SSAHGTATSTTtavDGTQND..SLLD...FIM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     185.76|      58|     191|    1280|    1343|       3
---------------------------------------------------------------------------
 1280- 1343 (83.54/85.57)	LHMVYSFSLDrRWMITVWSdhrGELIEfAVLEIQAAVIAGKPNGSPLVQVFAEAwSRTKKLAHR
 1477- 1534 (102.22/74.17)	LSMESMNELD.RWMLPLSS...GYLIK.QNSSQEAAVSCRQPSILELHLVYNKQ.SRNARLALR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     120.06|      34|     293|     306|     339|       5
---------------------------------------------------------------------------
  306-  339 (61.75/42.85)	ALYPAKLVFVPTSTRQSSARMAGMD..GVFSCDRGL
  602-  637 (58.32/39.97)	APTPAEEITHPPQQAQSSASPMVCDttPVASSDAGI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      95.62|      27|     250|     852|     885|       7
---------------------------------------------------------------------------
  852-  878 (49.47/44.00)	MDTIQPEKMNPDDIASLDQLCQQAVWG
  911-  937 (46.15/23.60)	TTLIQSIRGDITHVPSLPSTCVRVVQG
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP00867 with Med13 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) DFDFFKSEKKQQQQQQPSCSMMELDKPEPVNDSMNVSTAAPTTTDIVIPDTIKSEPFDLSAQPVAPTPAEEITHPPQQAQSSASPMVCDTTPVASSDAGISTTAPGTVDMSICTTPDIRQHTYQQSIPHVVTTSKPGYAMDNL
2) NPADEDTPMTMESALEDSATSAPYTVTPTDQHPEETPVISQDIAAT
3) YMGGGKFDYKSPSNDIGASETADQDVKLNRYRPDYVPPKILVDEAKREEEDKNNIGDGKNEDDDDDDDASETGSTSTNTSSSDESDQSDASSSDVSLSSHGDEQSGNVLERI
538
456
701
680
501
812










Molecular Recognition Features






MoRF SequenceStartStop




1) YIRRLL
819
824