Description | Mediator of RNA polymerase II transcription subunit 17 |
Sequence | MSGQDTAEQDFEPWKKLKLSFERPYKDDAGNPIPVLYDLTPEGERIYEPRESASVKLETNLRRIFLERGADFFERRDGLLSDSKPQNTAGAEQVENGEEDVAGDSDPVTKTMSVEELYAMRVEIMPHLFIALGEMTHARDLLNAVLSGTLNGQTNANAEPSSSLISATLVTIPPPIVSVQAFNAQITIGGKDEALRKAARLFKSAAESMERGRVRGEKYWVDALRIRRANWGLTPAPLPPGSATGKGADKTSKDFIISYGLEGSPAFFRRRAIAQMPISLGDSSRELVFPLRQTTRLRISILTTAESWAQPCSFASPRPASGPTDPEIVLKVAQTEVVDQEIFSLLVKEAGQLPTASARVSERLIAIDAAQGLDLVFELVDASVNMQASQSDGTGGENMCELIYHVLHVFLLRRHGLPLQDKGGVANKPSEFPLTLLQPIIDLLQYRVFCERVELELRKAVNALTAVGIPSTLSFTAVGEPGQLLVSLLSEHGKKAVGGQAVIRVDNWHTLWFTFVSPSTLTAHLSQATLTISSLPQLSQLLMDEIERFLLQRISGIGRGLCQSLGGIWFIDLNRCVAKWEGSVLNFKVFFGSDLTIGCSAFRLDATTGKQGNTQTYVSGYVSLMNWIQKIIQESARQFVLK |
Length | 642 |
Position | Head |
Organism | Galerina marginata (strain CBS 339.88) |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Basidiomycota> Agaricomycotina> Agaricomycetes> Agaricomycetidae> Agaricales> Strophariaceae> Galerina. |
Aromaticity | 0.07 |
Grand average of hydropathy | -0.112 |
Instability index | 36.42 |
Isoelectric point | 5.72 |
Molecular weight | 70476.68 |
Publications | PubMed=24958869 |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364140 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP00853 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 133.62| 43| 140| 346| 414| 1 --------------------------------------------------------------------------- 53- 95 (71.30/35.19) ASVKLETNLRRIFLERGADF.FERRDGL..LSDSKPQNTAGAEQVE 356- 401 (62.32/60.48) ASARVSERLIAIDAAQGLDLvFELVDASvnMQASQSDGTGGENMCE --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 3| 100.18| 27| 35| 458| 488| 2 --------------------------------------------------------------------------- 458- 484 (44.73/24.17) RKAVNALTAVGIPS..TLSFTAVGEPGQL 494- 519 (30.68/17.76) KKAVGGQAVIRVDNwhTLWFTFVS.PS.. 521- 541 (24.77/11.45) ......LTAHLSQA..TLTISSLPQLSQL --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) GQDTAEQDFEPWKKLKLSFERPYKD 2) NPIPVLYDLTPEGERIYEPR | 3 31 | 27 50 |
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Designed by Dr. Shailesh Lab & Dr. Jitendra K. Thakur Lab