<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP00848

Description Uncharacterized protein
SequenceMREKKEEKQSATLPVYESHPPPWLPKIHGTADLGYVGFHPPRPGQDEDGLSESNIKNGFILPQAVPVESFSAHAMINESLHSTETLTKLEELMNEVFIRRADRVPPVPSSTFRIPTRVTLNDAKRQAWFADLANPDVPLYKLGKSVPHGAKGGDLLDLLHSNNVEISRAVWFLRVFGANETAGLRNKPSYVPTQYSIDWANVVTGYMKKQLVEIALPSAPRPLLNIKQTFKGVLADPDTREKWMSRFTYCLKLLRTFYAEDLVDHRTFLTWLVHQMITCNLAQSGFLTRLADEYLGDILFSRALSKPLVEACLAKLSEIRTASARDFLKDTEDLLKVLLQRACLTLPDAFVSPKMWSTYSSLLDEIMFETAMTLPNARSVEQNTRDLEGIILDNFADIKKRNEALLFRGPIAQVSARLGTAVSDVKLLNSIFGDTEIGSISYFRQDINDISFKEKLDLLLDWSVTPLQYGDHRPFAAVTLIRIWRDKARDRASRRDITIPSELLQDRLFDWLDTSDVAGDPNNIRYIALLYGKLVKHEIFSYASYIQRLIARGEAGLSNAQGPASRHRLFLSWIPLFNSTPSLIHQRRVTLHGARARDIPEDATEREIRREIRTVTPDLFEGATLATWSSTTTLLERCKKLMTATRFEQVRTFRHWLLPVFKKSVAKAKPNLTVLFKSYIIAIELMTAAKCFHSALDLSLCMLEHSHNVESMNSLINTFYRYATIWSCMDVMPTIVKALDDAHHVWKLRGLQSRPLLALLMRFDGGRHLDGPSRERIASDIAAFTLALQPIVDQPDAVPQVLPEILLLAGDPNPNASFDLANRLWIKYRTSTDWAWKVWDNAVASLRQIPSMTPDIEARRACALRYGDFLWRVDQHLPKGLDNDVLQWLLGPGKAEVMALSTDAWDVLKAVLLFLVVHGALKTTTVLQGLIYPAWQLGVIGSAGQSPVSETYLSAANKLAFLFLLQEDANEDIVPPTDLFEVQCIRTRRQAVYNEPHFPLLVASIPTLISLENNDDIPESLRTESTALRCRICQEPGFRRGAYRNLDVIREAFENSPYLSDEDPSSEHLSKRAIAGLKMILCDSTDETNIYDWPEVTCLLTPWKIAATTIQMQLQVKQLGRALNHEPTSECATANLNKLTSMLFHHTKTAEEAYYVGEMARGADSTVAAKFVNNGLQCMTEFFSDPQSDSADCVRRVGELLRVLIHVSQPFRESPAALLSVDPQVQEAFVVALDSRFKELEAEMQNDKSPAQSSQNLILLSRLLHFILSFKSTWTSKSKETFLGLPKLIFRLTLHTASEGDLYLNTYPILIDTLLVLYDEIFLDSKSIAFDPFRYYPNIPINDLPSDMPPEYRKQMATLLARLPSDSVVTDLVLAHHDSQGNVVYGAVVVNKPWEWIENLGEPILLDPKEEKERDEKERLKVRHLFKNSGSIPMENFGTLITGDSVKSDMLSESENAMEGCLRSFGDGLSESIFIRDWRETRLESKPSPDTIARLRGEDSDALVGDASNPQALRASPTSSTISRSSTQATTSSGLRQHQPHSPSQTVQSQRSNSTLHEVIDVDSLPMTGTSKGKETMKRKATAAAISDDEVEIIAGPVPGRSTVAAKKQKANKGPAEKSTRARKK
Length1625
PositionKinase
OrganismGalerina marginata (strain CBS 339.88)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Agaricomycotina> Agaricomycetes> Agaricomycetidae> Agaricales> Strophariaceae> Galerina.
Aromaticity0.08
Grand average of hydropathy-0.245
Instability index45.28
Isoelectric point6.29
Molecular weight182541.53
Publications
PubMed=24958869

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP00848
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.97|      16|      17|    1332|    1347|       1
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 1332- 1347 (32.34/21.91)	P.FRYYPNIPINDLPSD
 1350- 1366 (24.63/14.63)	PeYRKQMATLLARLPSD
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     253.56|      87|     289|    1180|    1281|       2
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 1180- 1281 (119.80/112.98)	TEFFSDPQSDSADCVRrvGELLRVLI.HVSQP..FRESPAAlLSVDPQVQEAfvvALDSRFKEleaemQNDKSPAQSSQNLiLLSRLLH...filSFKSTWTSKSKET
 1481- 1576 (133.76/84.04)	TRLESKPSPDTIARLR..GEDSDALVgDASNPqaLRASPTS.STISRSSTQA...TTSSGLRQ.....HQPHSPSQTVQSQ.RSNSTLHevidvdSLPMTGTSKGKET
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     233.58|      95|     289|     749|     852|       3
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  114-  189 (43.70/17.95)	IPTRVTL.NDAKRQAWFaDLANPDVPLYKLGKSvphgakggdlldllhsnnveisravWFLRVFGaNETAGLRNKPS............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................
  749-  801 (35.74/35.96)	.............................................................................yvptqysidwanvvtgymkkqlveialpsaprpllnikqtfkgvladpdtrekwmsrftyclkllrtfyaedlvdhrtfltwlvhqmitcnlaqsgfltrladeylgdilfsralskplveaclaklseirtasardflkdtedllkvllqracltlpdafvspkmwstysslldeimfetamtlpnarsveqntrdlegiildnfadikkrneallfrgpiaqvsarlgtavsdvkllnsifgdteigsisyfrqdindisfkekldllldwsvtplqygdhrpfaavtliriwrdkardrasrrditipsellqdrlfdwldtsdvagdpnniryiallygklvkheifsyasyiqrliargeaglsnaqgpasrhrlflswiplfnstpslihqrrvtlhgarardipedatereirreirtvtpdlfegatlatwsstttllerckklmtatrfeqvrtfrhwllpvfkksvakakpnltvlfksyiiaielmtaakcfhsaldlslcmlehshnvesmnslintfyryatiwscmdvmptivkalddahhvwklRGLQSRPLLAL.....LMRFDggRHLdgPsrERIASDIAAFTLA...LQPIVDQPDAVpQV
  802-  907 (154.14/95.45)	LPEILLLaGDPNPNASF.DLANRLWIKYRTSTD.........................WAWKVWD.NAVASLRQIPS.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................mtPDIEARRACALrygdfLWRVD..QHL..P..KGLDNDVLQWLLGpgkAEVMALSTDAW.DV
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      68.86|      16|      25|     334|     349|       4
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  304-  319 (17.48/ 7.36)	LSKPLVE.ACLAkLSEI
  334-  349 (27.49/15.82)	LLKVLLQRACLT.LPDA
  362-  377 (23.89/12.78)	LLDEIMFETAMT.LPNA
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.44|      12|      19|      11|      22|       5
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   11-   22 (25.10/14.87)	ATLPVYESHPP.P
   31-   43 (21.34/11.46)	ADLGYVGFHPPrP
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      96.35|      25|      25|     616|     640|       6
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  239-  252 (19.98/ 8.18)	.........TREKWMSRFTY...CLK
  616-  640 (45.09/27.89)	TPDLFEGA.TLATWSSTTTLLERCKK
  643-  663 (31.29/17.05)	TATRFEQVrTFRHW.....LLPVFKK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.25|      18|      19|    1115|    1132|       7
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 1115- 1132 (31.56/21.46)	QVKQLGRAL.NHEPTSECA
 1135- 1153 (25.69/16.02)	NLNKLTSMLfHHTKTAEEA
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.48|      12|      17|    1301|    1312|      10
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 1301- 1312 (20.97/14.53)	DLYLNTYPILID
 1320- 1331 (19.51/12.93)	EIFLDSKSIAFD
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      72.50|      22|      99|     917|     938|      11
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  916-  937 (37.39/28.00)	VVHGALKTTTVLQGLIYPAWQL
  938-  959 (35.11/25.76)	GVIGSAGQSPVSETYLSAANKL
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP00848 with Med12 domain of Kingdom Fungi
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