<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP00847

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMDPAAQTDMNMIVDLEPSTSKSAHMNGISLDGFLDPTLEELERELPVVYNDQIPLGDLLSRVVQSIYAELSELAETMPNMSDTARKRTLADWVVKTKKQVVKLYAVAKWSRDADTIQKSMNITAFLMNQNQQFEDTIRGLTFGKESLDPARLRNHDLLTSLDVLTTGSYLRLPTCIKKLAIPSTLLTDAQVTKTLSDMEETIRYRLRMTEIIPVEMSQYHIADGRVHFTVPKLFSTSLCLQGGETDGGWFFINTEFLINVGGDLTGLQEFPRIPTGVIKRHITDEADARLRFYLPPPTPQSPVPEIATRTQLPQGVVDAPLVRLYNFLQMMSLSYQLEILWYQAERMRSLGWADYLTIQMSSDRKSLRASYWIRPPLPPTAPGRPRPKIPLLGGTLIMSIVETRAPAQAGPGPARKSRQRVLARLQQKSKLGNGKPSDEVEGLKFVVQWEPAKGALGVLVPLEETYLPEDALRIDADNLDFEFMLRSVIHKHSAALLRGFQDQLQHGPTKVFSQPSVVTFILAGDQQALRVHLCADEVVIITIDTRTGRLNLRDTGDLAAAGRGPRFAAISDKLNENPTVLMDALFRLRLATILDLAEQKANYLGLQNYRRRHIMQDEIRKLGTDARGTLFIQLSNFPNHYLVLVVMDQRFQYALITTKAVPEEAFGGMSLEDIAWLDFDRIHDAAFALSASDRLNSWSNKLKREGDGQDMGNDLYSLPHAGFNLDTQGLRELYSYCCARVAFINVERQFKIRGIPFTHVNPTSNISVTPELARIQSSLARSVPALCVQSKDILSGAPAAEAAMPNIRVIPLNWWSNEKAQVVTCVKLKYVQQPMGKTASGSTVIRPSKRIIYDTTEAVVSFLSENVNTCVDEFLEEWARVSKMVVIAREVAQMAKHTKWRDVRLLSFDLQTVEFAYSQDYTVSISCEDQLSPTGGNFDLEFSRIRPHDAMDTDEGYFNPHEDAEPFLRDILRHAHGRLAPSLHYLVTLLRDTLPIVVELEAVRKESQQSGRNVDIFAKAAGWYRLLYGDLKHALDFRLMSEQRVAILDASHSLFDIQIPGKPPPNDPVIDGLVLQRIPRFRELMVNTVQEGLTSGKLTMGKIAAIDVGVVCDGAGVGFLTKAIHAQVLEQIKP
Length1134
PositionTail
OrganismGalerina marginata (strain CBS 339.88)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Agaricomycotina> Agaricomycetes> Agaricomycetidae> Agaricales> Strophariaceae> Galerina.
Aromaticity0.07
Grand average of hydropathy-0.186
Instability index41.05
Isoelectric point6.27
Molecular weight127111.47
Publications
PubMed=24958869

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP00847
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     173.12|      54|     120|     889|     949|       1
---------------------------------------------------------------------------
  889-  949 (85.86/83.78)	REVAQMAKHTKWrdVRLLSFDLQ.TVEFAYSQDYTVSIscedqLSPTGGNFDLEF.SRIRPHD
 1012- 1067 (87.26/64.16)	RNVDIFAKAAGW..YRLLYGDLKhALDFRLMSEQRVAI.....LDASHSLFDIQIpGKPPPND
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     261.73|      83|     120|     650|     744|       2
---------------------------------------------------------------------------
  650-  744 (124.43/102.12)	RFQYALitTKAVPeeAFGGMSlEDIawLDFDRIHDAAFALSASDRLNSWSNK.......LKREGDGQDMGNdlyslPHAGFNLDTQGLRELYSYCCARVAFI
  774-  863 (137.31/80.19)	RIQSSL..ARSVP..ALCVQS.KDI..LSGAPAAEAAMPNIRVIPLNWWSNEkaqvvtcVKLKYVQQPMGK.....TASGSTVIRPSKRIIYDTTEAVVSFL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      70.96|      20|      62|     212|     231|       4
---------------------------------------------------------------------------
  212-  231 (38.88/29.55)	IPVEMSQYHI...ADGRVHFTVP
  273-  295 (32.07/22.89)	IPTGVIKRHItdeADARLRFYLP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP00847 with Med14 domain of Kingdom Fungi
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