<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP00845

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMAAVPLAALWYARLAGSNDAIEHVRRVAQFASLGPEQSLYLFSLSGPVDTAHDGLHVLESSEFTSLLSTPLTATSWLPDNQPLVAHFLHAVRCAVIHRITLDAPVRRFKNGFLLAHHRTPVDWAYNPITRPLIFCQLQIHFSYGPDGAPTHLLVHPMLIPTPLLDISPSLPAGTPITLLPYGTPAYFLAAYSGPTSGLVKQFQASLQGLGAGRWAENPTFLIAWIKVENKQGEDKGITIIYPSALCLSYLPSSTPRLPLDYIPELPTPLQPSPPPKIAFPPKRPSILSSPTSEALHTFRALTVSKTKDLRQVATEVGGYVDAVARERDRERERLKRERESGTASSPKMSRTSAPVSTPASAAASAPTPVSVAETPAPTPAAPPAAVVPPPLPTVQPSTSVQNFYPSPPQSVQAPAVPGNTSPVVETAPVKPPTPLPVEVAPPPPSTSYDPYSMDTESWAQSSYLGMDMDMDFGMDDIGMGMSFGMDMNMNMVDPTSGGGGSGNAGGGGFAARSGAGSMGFDDAFTDDDFSFFDRPSRPAAVPVSAGTHSRVASGSGLHNLTSPSVIGTGMSPPNFGELHGLSSSLGSAGVHHTWTPGGPLDGFTPRSLNEHESVPPELMPSVSLSLTTPMHQTPDTPAPMTPNVYLEPAADLHSGLGHGGAGTRDSITKSSHAHPPSAFEPIPFAEYHRRADGKYAVGKFAFSLPSPPAEDGYFGGDEEDMGVVKGEASSPGWRVRYDAVTDPRVGVVRKLIGVKRKVPPGPGVGYMGRRRMSYDDWEWEERRGGKDVKTEGGELGEGVDEKEPVDSEEEEEGEEEEEEEDVDSPMLSRPTTPPPSYLPLGPTLLHTQFQHAQLLPLSIPLRPPGAAVALEMGLAPVHLHPHSHMQMQPMLSVPTPVSPAATMGAASERSRSLEAAAFAVAAEVVENAVWAETWRAANAAGGGGGGVNVNAGAGVGAGMGPGMGAGVPIGAGVGARVWSADAKVVAGLLGGIKLGDGVQVQGPLGLAEVFGLGDDAEKHLQPLEEPYISIGKGDAVVQMKPPALRFWEKLGLDPKGGRKDLSAFVLFEEDLGGAGEQRQGHVEGWLRSVMAVYQAKHYGTMSLGKSGVCLKDGVVPLRYDATFRKSLTAFVGSLVPPQPTLVIFLVVPMTIMSLSSPVLRQILSVSKKVLGTYSASQIFFQFVPENHIFCALERTPAHGSACDVLASSVYNRVLVPVDRLRPRSDGGGAPRSPLLLDADPDRVRRLFMAPSFTLARPLHSRVSYVRAAHTSLDVMDRGTLLHVGYHLTACGKWILACCVDQRGEAYDLGVWLTQMQTPGREQEGEGEDVGERGVGVGVGAQGDVGEEDEEGAERPLSDEEYAVRKVWDFGMESARKANVEWRVVFARLGVMGEKEMNAWSALLNDKVVASREQPPLHHSVVCVVPDASWLFLPSKSGASLFPLPIPRPTAPAPSRSSSSSSAAKQHSVFTDVSALTYAVYPKNRISISVPPSLSDLGLSQSFIPEVASSASTLSSPPSPNPQSNAGNSSSQATSSTDCSSISPSATYLPHPVTFLPQASSILIRVPHSSSSSSASMTHTHLLRTTHSISYTHSEQASSSAKVPDDKQLLVDVTKNYHELAVLARVRWKLDGTGGHEGLPFHLAAVDAMRMSLDRDWERLEAGGES
Length1665
PositionKinase
OrganismGalerina marginata (strain CBS 339.88)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Agaricomycotina> Agaricomycetes> Agaricomycetidae> Agaricales> Strophariaceae> Galerina.
Aromaticity0.07
Grand average of hydropathy-0.204
Instability index52.92
Isoelectric point5.68
Molecular weight176991.93
Publications
PubMed=24958869

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
ECO:0000256	RuleBase:RU364134
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP00845
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     264.17|      59|      59|    1490|    1548|       1
---------------------------------------------------------------------------
  556-  593 (33.56/11.68)	GLHNLTSPSviGTG...........MsPPNFGELhGLSSSL..........GSAGVHHT....................
 1425- 1462 (52.98/23.91)	............................PDASWL......FLPS......KSGAS.LFPLPIPRPTAPAPSRSSSSSSA
 1470- 1535 (86.60/45.07)	TDVSAL......TYavypknrisisV.PPSLSDL.GLSQSFIPEV.....ASSASTLSSPPSPNPQSNAGNSSSQATSS
 1536- 1599 (91.03/47.86)	TDCSSISPS..ATY...........L.PHPVTFL.PQASSILIRVphsssSSSASMTHTHLLRTTHSISYTHSEQASSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     138.21|      33|      59|     893|     925|       2
---------------------------------------------------------------------------
  366-  387 (33.70/13.10)	.PTPVSVAET...PAPTPAAPPAA.......VV
  893-  925 (53.37/26.07)	VPTPVSPAATMGAASERSRSLEAAAFAVAAEVV
  955-  985 (51.14/24.60)	VGAGMGPG..MGAGVPIGAGVGARVWSADAKVV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     169.89|      23|      61|     598|     620|       3
---------------------------------------------------------------------------
  156-  175 (34.39/14.31)	PMLIP.....TPLLDISP.SLPA..GTP
  263-  274 (27.46/ 9.66)	PEL.P.....TPLQ...P.......SPP
  389-  408 (24.50/ 7.68)	PPL.PtvqpsTSVQNFYP.......SPP
  413-  431 (25.24/ 8.17)	APAVP.....GN....TSPVVETAPVKP
  598-  615 (26.95/ 9.32)	..........GPLDGFTPRSLNEHESVP
  616-  637 (31.36/12.28)	PELMP....sVSLSLTTP..MHQTPDTP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     140.13|      45|      59|    1171|    1219|       4
---------------------------------------------------------------------------
 1171- 1219 (71.60/56.37)	GTYSASQIFFQFVPE..NHIFCA....LERtPAHGSACDVLASSVYNRVLvpvDR
 1227- 1277 (68.53/41.80)	GGAPRSPLLLDADPDrvRRLFMApsftLAR.PLHSRVSYVRAAHTSLDVM...DR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      81.89|      22|     444|     495|     516|       5
---------------------------------------------------------------------------
  495-  516 (40.81/23.01)	TSGGGGSGNAGGGGFAARSGAG
  933-  954 (41.09/23.23)	TWRAANAAGGGGGGVNVNAGAG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.94|      14|      15|     794|     807|       6
---------------------------------------------------------------------------
  794-  807 (25.34/13.44)	ELGEGVDEKEPVDS
  811-  824 (24.60/12.85)	EEGEEEEEEEDVDS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.24|      15|      17|     995|    1011|       7
---------------------------------------------------------------------------
  995- 1009 (24.90/ 8.71)	GDGVQVQ.GPLGLAEV
 1013- 1028 (21.34/ 9.83)	GDDAEKHlQPLEEPYI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.20|      14|      17|     118|     131|       8
---------------------------------------------------------------------------
  118-  131 (27.61/13.12)	RTPVDWAYNPITRP
  136-  149 (26.58/12.37)	QLQIHFSYGPDGAP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.94|      16|      16|     825|     840|       9
---------------------------------------------------------------------------
  825-  840 (32.21/15.70)	PMLSRPTTPPPSYLPL
  842-  857 (27.73/12.35)	PTLLHTQFQHAQLLPL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     115.05|      25|      59|     648|     675|      10
---------------------------------------------------------------------------
  648-  675 (34.50/28.78)	PAADLhsGLgHGGAGTRDSITKSSHAHP
  683-  705 (39.04/20.64)	PFAEY.....HRRADGKYAVGKFAFSLP
  708-  731 (41.51/22.47)	PAED...GY.FGGDEEDMGVVKGEASSP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      97.96|      31|      54|    1304|    1336|      11
---------------------------------------------------------------------------
 1304- 1336 (46.82/34.55)	EAYDL.GVWLTQMQTpGREQEGEGEDVGERgVGV
 1359- 1390 (51.14/28.10)	EEYAVrKVWDFGMES.ARKANVEWRVVFAR.LGV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     107.90|      33|     866|     751|     786|      15
---------------------------------------------------------------------------
  751-  786 (55.04/38.39)	LIGVKRKVpPGPGvGYMG.........RRRMSYD.DWEWEErRGGK
 1622- 1664 (52.86/25.23)	LARVRWKL.DGTG.GHEGlpfhlaavdAMRMSLDrDWERLE.AGGE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.27|      13|      93|     192|     204|      16
---------------------------------------------------------------------------
  192-  204 (23.75/15.49)	SGPTSGLVKQFQA
  288-  300 (23.52/15.26)	SSPTSEALHTFRA
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP00845 with Med13 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) DWEWEERRGGKDVKTEGGELGEGVDEKEPVDSEEEEEGEEEEEEEDVDSPMLSRPTTPPPSYLPLGPT
2) FGMDMNMNMVDPTSGGGGSGNAGGGGFAAR
3) LEMGLAPVHLHPHSHMQMQPMLSVPTPVSPAATMGAA
4) LGSAGVHHTWTPGGPLDGFTPRSLNEHESVPPELMPSVSLSLTTPMHQTPDTPAPMTPNVYLEPAADLHSGLGHGGAGTRDSITKSSHAHPPSAFEPIP
5) PPAEDGYFGGDEEDMGVVKGEASSPGWRVRYDA
6) PSRPAAVPVSAGTHSRVASGSGLHNLTSPSVIGTGMSPPNFGELHGLSS
7) QTPGREQEGEGEDVGERGVGVGVGAQGDVGEEDEEGAERPLS
8) TEVGGYVDAVARERDRERERLKRERESGTASSPKMSRTSAPVSTPASAAASAPTPVSVAETPAPTPAAPPAAVVPPPLPTVQPSTSVQNFYPSPPQSVQAPAVPGNTSPVVETAPVKPPTPLPVEVAPPPPSTSYDPYSMD
776
483
870
585
707
535
1316
314
843
512
906
683
739
583
1357
454










Molecular Recognition Features






MoRF SequenceStartStop




NANANA