<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP00842

Description Mediator of RNA polymerase II transcription subunit 23
SequenceMGTEIQINNIVSEILKVEPIEEAFSCFLVHRPEQETEKVQNFQQELQSVLSGLNSDQQETGVKAYLLKAAEMTNHSRLQLLLSLLENLVANNILPARMVCECILSCEKLQYQQEDFWVECFRLIRRIIGGVDYKGVREIMKGCREKAQTIPARLNASVLPQLKALENVIEYIFDRNACLLPGYFIVTEIQKAYPDNKNWPHWKLAQLLSGFVESFRATAQMVSIIGHSRMLPVVEHSGYADHLINPWKLDPSTLKFSLKGNLPYDRELLEPQTGLLRYVLEQPYSRDMVCSMLGLQKQHKQRCVALEEQLVELVILAMERSETEADTDDISNSHWLWLHLSSQLIYFVLFQFATFPNIVMALHDKLAGRDLRRGRDHLMWVLLQFISGSIQRNPLNNFLPVLKLYDLLYPEKEPLAVPDFNKALCTHQMAMTCIWIHLLKKAQTEHLNIHRPIPHTLKVHHEFLQHLVMPNNTGLCMGSDYRIALLCNAYSTNQEYFTRPMAALVDTILGTQKGPQQPPLPPLANNAALASGPTTPLSMSILDSLTVHSKMSLIHSIVTHVIKLAQSKSNMALAPALVETYSRLLVYTEIESLGIKGFISQLLPTVFKSHAWGILYTLLEMFSYRMHHIQPHYRVQLLSHLHSLAAVPQTNQTQLHLCVESTALRLITGLGSAEVQPQLSRFLSEPKTLVSAESEELNRALVLTLARSMHVTGTGSETLSGTWCKELLNTIMQNTPHSWANHTLQCFPPVLNEFFQQNNVAIENKQQLKKAVEEEYRNWASMNNENDIIAHFSVQGTPPLFLCLLWKMILETDRISPIAYKILERIGARALSAHLRKFCDYLVFEFANSGGGQHVNKCVDAINDMIWKYNIVTIDRLVLCLALRTQEGSEAQVCFFIIQLLLLKAAELRNRVQEFVKENSPEHWKQSNWHEKHLAFHRKYPEKFAPEGILEQTGGPSSPYHSLPVYFGNVCLRFLPVFDIVIHRYLELPPVTKSLETLLEHLGCLYKFHDRPVTYLYNTLHYYERKLRDRPPLKRRLVAAVLGSLRDIRAPGWSLSEPYQTYMQRQTDETTWVPELDYYVRLVRRIVETVSGKPHFPATDWRFNEFPNPAAHALYVTCVELMAVPVTPALVGTNLLDVVAKGYTVIPSNQIHMWINSVGLIMAALPDSYWSVLHDRLVEVITCPQLTQWKYRNTPFQLFNFAATHDSLLENKFSYMLALAHSMWHHAGVGQITTVPQFVREKVHPVVKTEEQFLFLCHLVGPFLQRFNTDRPRCVTDLTVELYELLEQVDKNVTHMQYMDPICDLLYHIKYMFVGDLMKNEVECIIRRLRPALQMRLRFIAHLNIEEINAA
Length1351
PositionTail
OrganismZootermopsis nevadensis (Dampwood termite)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Polyneoptera> Dictyoptera> Blattodea> Blattoidea> Termitoidae> Termopsidae> Zootermopsis.
Aromaticity0.09
Grand average of hydropathy-0.086
Instability index46.70
Isoelectric point6.88
Molecular weight155208.27
Publications
PubMed=24845553

Function

Annotated function 
GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP00842
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.87|      11|      47|     193|     204|       1
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  193-  204 (21.57/14.42)	YPDNKNWPhWKL
  239-  249 (23.30/10.62)	YADHLINP.WKL
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      68.06|      24|     120|     564|     608|       2
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  575-  604 (36.70/55.91)	PALVET.........YsrllvyTEIESLGIK......GFISQLLP
 1128- 1166 (31.35/ 9.25)	PALVGTnlldvvakgY......TVIPSNQIHmwinsvGLIMAALP
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     266.90|      78|     320|     912|    1016|       3
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  360-  453 (90.41/42.45)	MALHDKLAGRDLRRGrdhlmwVLLQFISGSIQRNPLNNF.....LPVLKLYDLLYP.EKepLAVPDFNKA.LCThqmamtciwihLLkkaqtEHL....NIH.RPI...
  934- 1016 (133.24/118.56)	LAFHRKYPEKFAPEG......ILEQTGGPSSPYHSLPVYfgnvcLRFLPVFDIVIH.RY..LELPPVTKS.LET...........LL.....EHLGCLYKFHDRPVTYL
 1301- 1343 (43.26/13.29)	................................................PICDLLYHiKY..MFVGDLMKNeVEC...........II.....RRLRPALQMRLRFIAHL
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     111.07|      27|     555|     495|     521|       4
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  495-  521 (48.60/31.23)	EYFTR.......PMAALVDTILGTQKGPQQPPLP
 1022- 1051 (22.87/10.74)	.YYERklrdrppLKRRLVAAVLGSLRDIRAP...
 1077- 1097 (39.60/24.06)	DYYVR.......LVRRIVETVSG......KPHFP
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.21|      15|     555|      75|      90|       5
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   75-   90 (20.28/14.99)	HSRLQlLLSLLENLVA
  632-  646 (25.93/14.57)	HYRVQ.LLSHLHSLAA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      74.93|      24|     556|     290|     320|       6
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  290-  313 (43.94/38.86)	CSMLG..LQK..QHKQRCVA.LEEQLVEL
 1257- 1285 (31.00/12.43)	CHLVGpfLQRfnTDRPRCVTdLTVELYEL
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.91|      12|     299|     864|     886|      10
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  864-  878 (18.81/10.86)	DMIWKyniVTIDRLV
 1167- 1178 (24.10/ 6.03)	DSYWS...VLHDRLV
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      90.03|      18|     279|     455|     472|      12
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  455-  472 (32.69/19.50)	HTLK..VHHEFLQHLVMPNN
  742-  759 (32.32/19.19)	HTLQ..CFPPVLNEFFQQNN
  766-  785 (25.01/13.08)	QQLKkaVEEEYRNWASMNNE
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---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      84.10|      24|     533|     703|     726|      13
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  703-  726 (44.61/29.03)	LTLARSM.HVTGTGSETLSGTWCKE
 1217- 1241 (39.49/24.84)	LALAHSMwHHAGVGQITTVPQFVRE
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP00842 with Med23 domain of Kingdom Metazoa
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