<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP00817

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMAPVPLEGHQTPAGNNVPQEGSRGGTISLTVLIDFIIQRTYHELTVLAELLPRKTDMERKIEIYNFSARTRQLFVRLLALVKWASSITKVERSTHIMGFLDKQSLLFVDTADMLARMARETLVHARLPNFHIPAAVEVLTTGTYCRLPACIRERIVPPDPITPSERRSTLLRLNQVIQHRLVTGNLLPQMRNLKIESGRVTFTVEHEFEVSLTVMGDGPNIPWRLLDIDILVEDKETGDGKALVHSLQVQYIHQVIQSRLVDNPQPLTEVYNCLHFFCQSLQLEVLYSQTLRLCRDRLDDHIHVDEYTPGKCLSISYWRELTCKDPKSELGYRLTVQVDTHDPARPLTVVHVPSLGNKECEIADRAIRTDLLSMERLLVHTIYVRTRSRLTELKQEVQTMMKDVECHLQGSPAILSVPVLQPCLRAEQLLVTVDTHTGMLQCHVPQYEAPLIPELQTALNGDHSRLPTLVSELRYWITQRRCEKTLQHLPATPHERLPLLHHPDHPMSKIGRHRMFVRLHKHPNVILIVEFKEKESTQCEIDCSFYLAVVKHSSIEDDPHDDSIETEIPKMYLKVLTLIEFDTFVITHGPFTSVDDQSEKFPGKRKPGGRQEPGSRRTKHPAYFIPELAHVVALCDERIPFVTLAQELTKREIAHQGLQVEANATALVLRLVQLPPSPGVDTQSASWLALLKRLLSVAIRVQGKATKNWMAEFVFYGSPLASSHPKEQGLRRPVYFQYDMGTADTVSKTVDALLNDWSQIVHLYTVVEDLAEYFRIEKYNLSNMVTIKSYSYSRLVLGYGPDRGATVTVDWNSSDKAFRLIFGATNNCVNAHSLMREQLEAHLNRHRNLAQIVHILHETYEPLISISKLPTIPQLGVHNQRPQVPVQTFTIMPQSPTLLRLAYQGMYCLELRLRGGGLVSLRDGAYSRFDRSNVVDEFTPTQGLKAFLSKYVDETAVFRRRSQSEDDNPPSPITMDSDGGGGPMSFLGAHHRGPQSPAQQREGGLRFHPPLTPPSGSNPHTPASPHPAMSQAGQHQSFGSSPATSFNLASPPSLPPNINPSPNMLPHPSPGGLLANSPSNPLHVPSPAGLMPTSSPGPCPTVPVGHSPASSFMGQTGHTDGSPFPSSQSMASPATSNWPGSPSMPRPSPARPGQSPGGTGHSALHSPQADHKPGVSHLSRVLPQRSWAGAVPTLLTHEALDLLCSPSPHPQHLPGPELSPLERFLGCVYMRRQLQRFIQNDDCLTGIPTTEPGVVHFKVETLQCRVGLNPQHLQSLHIKVSPLPDHKEQWTVEEMQIIEKFFDTRAAAPPYKPNALSGFGRMLNVPYNVLKDFVQIMKLELIPGLVQQQQMKWAVQWSLRTPPSATPIVPTGMAAVLVCRTKILVFLQITRIGGPYQSTIEPPSLVLPLVYDVSTNLTQLAEKRDPGPASATTAASLQLKRFAEFGVSHNECSLFPAVRDLLCSLSLPSESQAQVASSPAPPTMQPSPAMQMHSPMPGGVVGMPPQTGAGGPPQQPSGPPQSPYPVGITMGQHPMMGPQ
Length1539
PositionTail
OrganismZootermopsis nevadensis (Dampwood termite)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Polyneoptera> Dictyoptera> Blattodea> Blattoidea> Termitoidae> Termopsidae> Zootermopsis.
Aromaticity0.06
Grand average of hydropathy-0.283
Instability index60.04
Isoelectric point7.67
Molecular weight170715.96
Publications
PubMed=24845553

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP00817
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             7|     233.73|      23|      23|    1049|    1071|       1
---------------------------------------------------------------------------
  968-  988 (26.68/ 7.49)	..NP........PS.....PITMDSD.G.GG.GPMSFLG
 1049- 1071 (48.13/21.24)	A.SP........PSL....PPNINPS.P.NM.LPHPSPG
 1075- 1097 (35.09/12.88)	A.NS........PSN....PLHV.PS.PaGL.MPTSSPG
 1105- 1128 (28.88/ 8.89)	GhSP........ASS....FMGQTGH.T.DG.SPFPSSQ
 1131- 1157 (32.80/11.41)	A.SPatsnwpgsPSM....P...RPS.P.AR..PGQSPG
 1476- 1498 (37.58/14.48)	A.SS........PA.....PPTMQPS.P.AMqMHSPMPG
 1502- 1525 (24.57/ 6.13)	G.MP........PQTgaggPPQQ.PSgP.PQ.SPYP...
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      89.76|      29|     271|    1174|    1207|       2
---------------------------------------------------------------------------
 1174- 1205 (42.16/29.96)	GVSHLsRVLPQRSWAGAVPTLLthEALDLLCS
 1253- 1281 (47.60/23.25)	GVVHF.KVETLQCRVGLNPQHL..QSLHIKVS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     107.56|      31|      33|     397|     428|       3
---------------------------------------------------------------------------
  397-  415 (24.40/ 9.64)	.....................VQTMMKDVECH..LQGSPAIL
  417-  451 (49.60/29.41)	VPVLQPCLRAEQ.....llvtVDTHTGMLQCH..VPQYEAPL
  452-  491 (33.56/13.39)	IPELQTALNGDHsrlptlvseLRYWITQRRCEktLQHLPA..
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      81.34|      25|      33|      55|      79|       4
---------------------------------------------------------------------------
   55-   79 (43.11/29.52)	TDMERKIEIYNFSARTRQLFVR...LLA
   88-  115 (38.22/25.34)	TKVERSTHIMGFLDKQSLLFVDtadMLA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     112.29|      28|      32|     283|     313|       5
---------------------------------------------------------------------------
  285-  313 (49.08/37.15)	VLYSQTLRlCRD.......RLDDHIHVDEYTPGKCL
  315-  347 (41.29/20.47)	ISYWRELT.CKDpkselgyRL..TVQVDTHDPARPL
  928-  944 (21.92/ 8.32)	...................RFDRSNVVDEFTPTQGL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      94.99|      29|      32|    1391|    1420|       6
---------------------------------------------------------------------------
 1391- 1420 (47.75/28.63)	RIGGPYQSTiEPPSLVLPLV..YDVSTNLTQL
 1424- 1454 (47.24/24.28)	RDPGPASAT.TAASLQLKRFaeFGVSHNECSL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      35.08|      10|      83|     173|     182|       7
---------------------------------------------------------------------------
  147-  156 (17.98/10.20)	LPACIRERIV
  173-  182 (17.09/ 9.33)	LNQVIQHRLV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.95|      17|      32|     211|     227|       9
---------------------------------------------------------------------------
  211-  227 (32.56/21.11)	SLTVMGDGPNIPWRLLD
  246-  262 (29.39/18.27)	SLQVQYIHQVIQSRLVD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      94.80|      27|      79|    1206|    1237|      10
---------------------------------------------------------------------------
  676-  702 (46.22/23.11)	PSPGVDTQSASWLALLKRLLS.VAIRVQ
 1206- 1233 (48.59/41.60)	PSPHPQHLPGPELSPLERFLGcVYMRRQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.74|      14|      24|     535|     549|      12
---------------------------------------------------------------------------
  535-  549 (20.97/18.14)	ESTQCEIDcSFYLAV
  562-  575 (24.78/14.79)	DSIETEIP.KMYLKV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.94|      18|      83|     866|     883|      13
---------------------------------------------------------------------------
  838-  873 (20.58/10.07)	QLEAHLNRHRnlaqivhilhetyeplisISKLPTIP
  874-  896 (28.37/17.31)	QLGVHNQRPQ.............vpvqtFTIMPQSP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      68.17|      18|     114|     607|     624|      19
---------------------------------------------------------------------------
  607-  624 (34.93/16.82)	PGGRQEPGSRRTKHPAYF
  719-  736 (33.23/15.65)	PLASSHPKEQGLRRPVYF
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP00817 with Med14 domain of Kingdom Metazoa
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