<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP00815

Description Mediator of RNA polymerase II transcription subunit 12
SequenceMMGFSYEKRALKRPRLGPPDVYPQEPKQKEDELTTLNVKHGFTTVPQLSDEFGTARNCNITASKVGAYFNAILTKKEELNTLPDTGRKRQQINPKDNFWPATARTKNAIEAWFKDLAGSKPLSSLSKKAPNFNKKEEIFIMLCEYQVPMLRAAWFIKLSYAYTVAVSEVKIKKRQLSDPSQEWTATLIKFLKDQLNKLQDFYHQSGGNFSGYGSGGTANTANNSGSTGGNNTCTTSSATSGNNAAGGGSVTGASVNNGSSANTVVPSGSGSSSTNTSVNTSTACSTIQPSAVNSTQTPASAALPTMTEDQKLAQRQWQYCIQLAKYLYEEGLLERQEFLQWILELLDKMRSTPSDDGILKLVLPLALQYLDEFVHSELLARKLAYFCAKKLAQLCSVASDTAAVSMAFSSSPALPPSASPQSPLLPGNIGVLSQGGPTQMVPVNPLMVTFNEYMSCPHHRDLVLGLSAILQAITLDCPTALVWNCVGEGKSPSVLNGSPLDHLPCSPSTLPMPQRATNPAVRRQLRAAEDHVRNRSRAAEGRWSCDKWQQSSAGRTTSKVLTALDALDRHSFDRMDATNSLDTLYAKIFSPPGTKESSLTGTSCGNNSNTSNNGSNSTVSNNGTSGGDPLRENRADYSLLQDEAVVQILCEWAVSSQRSGEHRAMAVAKLLEKRQSDLMSGEVDAADEKDSVSSGNGAPTGLPVFQPLLMRFLDNDAPVLEDNPSAQNRAMFTNLVHLFSELIRHDIFSHDVYMCTLISRGDLNTGGPTMASSHHPTSNKPATPAESRGTVNNSGIQDDDGSLFPGIDLKPSKLDVQDHGRNMDYDDSKIDDDLDKLLQHIKEEQQNSLDAPDSPKDDGVPPGSLVAPPMASVTPVERAETGEMKSRHLLYTTHFPLPLDEPCSFHDCNQRHVLLYGVGKIRDEARHTIKKITKELCRLFSKKFSIDVSEGAKLKKHSRVEFSFEATTAKVQGLSYCDRHVVTWQCALTVIEMLSSFASGPSSYLPVQEHVAFLFDLMELAFNIYGLIDVCIQILKELPEIEAHLQGKQSTLMRSYTTSLSLYVVGVLRRYHCCLLLSPEQTTAVFEGLCRVVKHVTNPGDCSSAERCVLAHLYDLYSSCSLLKSKPHCVEPFGNAYPKIRQALYSTVQPSSSNHVCNAQFMADVFSNPRRGGKIEPHWARQLAETPNNRYSFVCNAVVAVCNETDNDRLNDLAITCAELTACCNSLSAEWLGVLMALCCSSNHSSHFIDVLTQVDVQDLSIHNSLAVFTSILIARHCFSLEDFVVHIALPSLVKACNEGRGDADIEAEAGARLTCHLLLRLFKTVECPQPALYSLGTSPHPIPCASTSIGYSIKLSCDRHLLAAAHNNIRVGPVLAVLKAILVVGDATAREGKTPSSKNKPEQSQQMHSSSTGSCSNKPPISGSSGGELSISHILGTSDILGGGDDPLLDLGVVDVEPATQAGQRPIASSVGGTASTMETAAGLSDFAQHVLRQICSQEWVLERCLQNPEELCHTDMLLDSMLTPKQAQRLLHMICYPETTAATEESLDQRHIIARILENLDQWTLRMSWLDLQLMFTQFPPGSSELNQWLDTVAKAAIDVFQLTTGGVSSGSDGKEEKRSGVRPSKPGSIWLVAPLVSKLPSAVQGRVLKVAGQVLESGNWSSKNRDKERNVHRSSSLLSHQPFLSLVLTCLKGQDDQREGLLTSLHSQLNQFFLLSKDERLSNYEDPRGRALMQDALQLRFSLVGGMFDTIQRNTAVTTDWAILLVQLISYAVIDLNNNSELFTTVIDMLATLIHSTLVSDSQSEKEENRKHYQNLMKKLKKELGDRSSPSIQHVRQLLPLPKVTAEVVVCQPMGCLTDTKGNKIAGFDSIDKKQGLQVFEKQRVSPWDLLEGHKNPAPLSWSWFGAVRMERKPLWYEDTHRLLKYHTHSLLKSPAYFLDPPPLPPEELDPPQEKPLKDDGKADTPNSSDQSPRGPGGNKRPKAQRRRRPKAGGPSAPSNGQPVMPGMPQQVQQPPQPPVPHLTYANQGGMFPTQSQWSYSQQQQQQQQQQQQQQQQQQQQQGYYSSQQLPAVGGPRFERPLNQSNPKQALSQMLRMRLPSNQYLGTQQPPPGFPQSIQRQQFIRQQLRAQHGAPGMQPPPQQGIFPQQQGGPTMYTGMQQGMNQNYAGYGGQPGSQMVSQQQLMGHAGQGMMGGFPGQQGGGFVSQQQAPGMMGSGGPIPPQQPRGAGEYMGPQGGMTAQQRAMAVQQGARPPYLQAPNVTMTTMGGPMGQQGQGQPQAAPPYGRAGGGGPGGTQVPQPPHATQQQQQNQQFQQQRMRQQMMAQQQQSNQQAPALVAHLQRQLSQQQQQSGGNQQNQQHNPYSHQPPPY
Length2373
PositionKinase
OrganismZootermopsis nevadensis (Dampwood termite)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Polyneoptera> Dictyoptera> Blattodea> Blattoidea> Termitoidae> Termopsidae> Zootermopsis.
Aromaticity0.06
Grand average of hydropathy-0.476
Instability index52.91
Isoelectric point7.22
Molecular weight259756.43
Publications
PubMed=24845553

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP00815
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      95.24|      20|      20|    2270|    2289|       1
---------------------------------------------------------------------------
 2032- 2059 (24.83/ 6.68)	GGmfPtqsqwsYSQQQQQ..QQQQQQQQQQ
 2197- 2216 (25.24/ 6.93)	GG..F......PGQQGGGfvSQQQAP..GM
 2270- 2289 (45.17/19.31)	GG..P......MGQQGQG..QPQAAPPYGR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      84.72|      15|      15|    2134|    2148|       2
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 2134- 2148 (34.01/12.27)	QHGAPGMQPPPQQGI
 2152- 2166 (27.13/ 8.19)	QQGGPTMYTGMQQGM
 2173- 2187 (23.57/ 6.07)	YGGQPGSQMVSQQQL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      84.91|      21|      22|     247|     267|       3
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  224-  243 (26.41/12.21)	...SGSTGGNNTCTTSSATSGNN
  244-  266 (30.73/15.54)	AagGGSVTGASVNNGSSANTVVP
  267-  289 (27.77/13.26)	SgsGSSSTNTSVNTSTACSTIQP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     138.12|      21|      21|    2313|    2333|       5
---------------------------------------------------------------------------
 2089- 2112 (22.99/ 6.51)	NPKQA........LS.QML..RMRLPSNQylgTQQ
 2113- 2130 (24.60/ 7.55)	PPPGF........PQ.SIQ..RQQFIRQQ......
 2224- 2254 (24.27/ 7.34)	PPQQPrgageymgPQ.GGMtaQQRAMAVQ...QGA
 2312- 2332 (38.43/16.55)	QNQQF........QQ.QRM..RQQMMAQQ...QQS
 2333- 2354 (27.83/ 9.66)	NQQAP........ALvAHL..QRQLSQQQ...QQS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.25|      19|      20|    1185|    1203|       6
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 1185- 1203 (36.48/27.13)	ETPNNR...YSFVCNAVVAVCN
 1204- 1225 (30.77/21.57)	ETDNDRlndLAITCAELTACCN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     263.89|      84|     273|     434|     522|       7
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  434-  522 (149.87/86.40)	QGGPTQMVPVNPLMVTF..NE...YMSCP..HHRDLVLGLSAIL.QAITLDCPTALVWNC..VGEGKspsvLN.GSPL...DHLPCS..PSTlPMPQRAT..NPAVR
  696-  797 (114.02/55.88)	NGAPTGLPVFQPLLMRFldNDapvLEDNPsaQNRAMFTNLVHLFsELIRHDIFSHDVYMCtlISRGD....LNtGGPTmasSHHPTSnkPAT.PAESRGTvnNSGIQ
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.76|      20|      44|    1421|    1440|       8
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 1421- 1440 (36.12/19.47)	PISGSSGGELS.ISHILGTSD
 1467- 1487 (30.64/15.42)	PIASSVGGTAStMETAAGLSD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.78|      12|      43|    1489|    1500|       9
---------------------------------------------------------------------------
 1489- 1500 (22.57/11.35)	AQHVLRQICSQE
 1529- 1540 (24.21/12.66)	AQRLLHMICYPE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.60|      13|      16|     799|     814|      10
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  799-  814 (17.32/18.83)	DDGSlfpGIDLKPSKL
  818-  830 (24.29/14.83)	DHGR...NMDYDDSKI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      74.05|      15|      15|    1974|    1988|      11
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 1974- 1988 (25.51/ 8.21)	QSPRGPGGNKRPKAQ
 1991- 2005 (25.08/ 7.94)	RRPKAGGPSAPSNGQ
 2299- 2311 (23.46/ 6.94)	QVPQP..PHATQQQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.24|      13|      15|    1090|    1103|      12
---------------------------------------------------------------------------
 1090- 1103 (21.86/15.50)	CrVVKHVTN.PGDCS
 1108- 1121 (21.38/10.08)	C.VLAHLYDlYSSCS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.59|      19|      20|     593|     612|      13
---------------------------------------------------------------------------
  593-  612 (28.45/22.49)	GTKES.SLTGTScGNNSNTSN
  614-  633 (30.14/17.35)	GSNSTvSNNGTS.GGDPLREN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     110.21|      32|      45|    1582|    1620|      14
---------------------------------------------------------------------------
 1561- 1580 (24.73/ 8.50)	.......NLDQW..T..LRM..SWLD...LQLMFTQ....
 1582- 1613 (57.50/44.76)	P..PGSSELNQWLDT..VAK..AAID..VFQLTTGGVSSG
 1626- 1661 (27.98/ 7.93)	PskPGSI....WLVAplVSKlpSAVQgrVLKVAGQVLESG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.49|      15|      20|     309|     323|      16
---------------------------------------------------------------------------
  309-  323 (28.71/13.62)	DQKLAQRQ..WQYCIQL
  329-  345 (20.79/ 8.15)	EEGLLERQefLQWILEL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      74.23|      17|      39|    1744|    1760|      18
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 1744- 1760 (27.27/17.70)	FSLVGGMFDTIQRNTAV
 1769- 1785 (22.09/12.87)	VQLISYAVIDLNNNSEL
 1786- 1802 (24.87/15.46)	FTTVIDMLATLIHSTLV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.45|      18|      20|     374|     391|      19
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  374-  391 (30.01/18.00)	VHSELLARKLAYFCAKKL
  397-  414 (27.44/15.79)	VASDTAAVSMAFSSSPAL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      38.93|      11|      47|    1889|    1903|      21
---------------------------------------------------------------------------
 1889- 1903 (17.24/17.95)	SPWDLLeghkNPAPL
 1937- 1947 (21.70/10.43)	SPAYFL....DPPPL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     249.23|      77|     113|     897|     974|      22
---------------------------------------------------------------------------
  897-  974 (128.18/84.10)	LPLDEPCSF.HDCNQRHVLLYG.......VGKIRDEARHTIKKITKELCRLFSKKFSIDVSeGAKLKKHSRVEFSFEATTAKVQGL
 1005- 1089 (121.06/75.15)	LPVQEHVAFlFDLMELAFNIYGlidvciqILKELPEIEAHLQGKQSTLMRSYTTSLSLYVV.GVLRRYHCCLLLSPEQTTAVFEGL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.21|      15|     296|    2060|    2074|      25
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 2060- 2074 (29.10/12.53)	QQQQQQGYYSSQQLP
 2358- 2372 (33.11/15.37)	QQNQQHNPYSHQPPP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP00815 with Med12 domain of Kingdom Metazoa
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