<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP00815

Description Mediator of RNA polymerase II transcription subunit 12
SequenceMMGFSYEKRALKRPRLGPPDVYPQEPKQKEDELTTLNVKHGFTTVPQLSDEFGTARNCNITASKVGAYFNAILTKKEELNTLPDTGRKRQQINPKDNFWPATARTKNAIEAWFKDLAGSKPLSSLSKKAPNFNKKEEIFIMLCEYQVPMLRAAWFIKLSYAYTVAVSEVKIKKRQLSDPSQEWTATLIKFLKDQLNKLQDFYHQSGGNFSGYGSGGTANTANNSGSTGGNNTCTTSSATSGNNAAGGGSVTGASVNNGSSANTVVPSGSGSSSTNTSVNTSTACSTIQPSAVNSTQTPASAALPTMTEDQKLAQRQWQYCIQLAKYLYEEGLLERQEFLQWILELLDKMRSTPSDDGILKLVLPLALQYLDEFVHSELLARKLAYFCAKKLAQLCSVASDTAAVSMAFSSSPALPPSASPQSPLLPGNIGVLSQGGPTQMVPVNPLMVTFNEYMSCPHHRDLVLGLSAILQAITLDCPTALVWNCVGEGKSPSVLNGSPLDHLPCSPSTLPMPQRATNPAVRRQLRAAEDHVRNRSRAAEGRWSCDKWQQSSAGRTTSKVLTALDALDRHSFDRMDATNSLDTLYAKIFSPPGTKESSLTGTSCGNNSNTSNNGSNSTVSNNGTSGGDPLRENRADYSLLQDEAVVQILCEWAVSSQRSGEHRAMAVAKLLEKRQSDLMSGEVDAADEKDSVSSGNGAPTGLPVFQPLLMRFLDNDAPVLEDNPSAQNRAMFTNLVHLFSELIRHDIFSHDVYMCTLISRGDLNTGGPTMASSHHPTSNKPATPAESRGTVNNSGIQDDDGSLFPGIDLKPSKLDVQDHGRNMDYDDSKIDDDLDKLLQHIKEEQQNSLDAPDSPKDDGVPPGSLVAPPMASVTPVERAETGEMKSRHLLYTTHFPLPLDEPCSFHDCNQRHVLLYGVGKIRDEARHTIKKITKELCRLFSKKFSIDVSEGAKLKKHSRVEFSFEATTAKVQGLSYCDRHVVTWQCALTVIEMLSSFASGPSSYLPVQEHVAFLFDLMELAFNIYGLIDVCIQILKELPEIEAHLQGKQSTLMRSYTTSLSLYVVGVLRRYHCCLLLSPEQTTAVFEGLCRVVKHVTNPGDCSSAERCVLAHLYDLYSSCSLLKSKPHCVEPFGNAYPKIRQALYSTVQPSSSNHVCNAQFMADVFSNPRRGGKIEPHWARQLAETPNNRYSFVCNAVVAVCNETDNDRLNDLAITCAELTACCNSLSAEWLGVLMALCCSSNHSSHFIDVLTQVDVQDLSIHNSLAVFTSILIARHCFSLEDFVVHIALPSLVKACNEGRGDADIEAEAGARLTCHLLLRLFKTVECPQPALYSLGTSPHPIPCASTSIGYSIKLSCDRHLLAAAHNNIRVGPVLAVLKAILVVGDATAREGKTPSSKNKPEQSQQMHSSSTGSCSNKPPISGSSGGELSISHILGTSDILGGGDDPLLDLGVVDVEPATQAGQRPIASSVGGTASTMETAAGLSDFAQHVLRQICSQEWVLERCLQNPEELCHTDMLLDSMLTPKQAQRLLHMICYPETTAATEESLDQRHIIARILENLDQWTLRMSWLDLQLMFTQFPPGSSELNQWLDTVAKAAIDVFQLTTGGVSSGSDGKEEKRSGVRPSKPGSIWLVAPLVSKLPSAVQGRVLKVAGQVLESGNWSSKNRDKERNVHRSSSLLSHQPFLSLVLTCLKGQDDQREGLLTSLHSQLNQFFLLSKDERLSNYEDPRGRALMQDALQLRFSLVGGMFDTIQRNTAVTTDWAILLVQLISYAVIDLNNNSELFTTVIDMLATLIHSTLVSDSQSEKEENRKHYQNLMKKLKKELGDRSSPSIQHVRQLLPLPKVTAEVVVCQPMGCLTDTKGNKIAGFDSIDKKQGLQVFEKQRVSPWDLLEGHKNPAPLSWSWFGAVRMERKPLWYEDTHRLLKYHTHSLLKSPAYFLDPPPLPPEELDPPQEKPLKDDGKADTPNSSDQSPRGPGGNKRPKAQRRRRPKAGGPSAPSNGQPVMPGMPQQVQQPPQPPVPHLTYANQGGMFPTQSQWSYSQQQQQQQQQQQQQQQQQQQQQGYYSSQQLPAVGGPRFERPLNQSNPKQALSQMLRMRLPSNQYLGTQQPPPGFPQSIQRQQFIRQQLRAQHGAPGMQPPPQQGIFPQQQGGPTMYTGMQQGMNQNYAGYGGQPGSQMVSQQQLMGHAGQGMMGGFPGQQGGGFVSQQQAPGMMGSGGPIPPQQPRGAGEYMGPQGGMTAQQRAMAVQQGARPPYLQAPNVTMTTMGGPMGQQGQGQPQAAPPYGRAGGGGPGGTQVPQPPHATQQQQQNQQFQQQRMRQQMMAQQQQSNQQAPALVAHLQRQLSQQQQQSGGNQQNQQHNPYSHQPPPY
Length2373
PositionKinase
OrganismZootermopsis nevadensis (Dampwood termite)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Polyneoptera> Dictyoptera> Blattodea> Blattoidea> Termitoidae> Termopsidae> Zootermopsis.
Aromaticity0.06
Grand average of hydropathy-0.476
Instability index52.91
Isoelectric point7.22
Molecular weight259756.43
Publications
PubMed=24845553

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP00815
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      95.24|      20|      20|    2270|    2289|       1
---------------------------------------------------------------------------
 2032- 2059 (24.83/ 6.68)	GGmfPtqsqwsYSQQQQQ..QQQQQQQQQQ
 2197- 2216 (25.24/ 6.93)	GG..F......PGQQGGGfvSQQQAP..GM
 2270- 2289 (45.17/19.31)	GG..P......MGQQGQG..QPQAAPPYGR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      84.72|      15|      15|    2134|    2148|       2
---------------------------------------------------------------------------
 2134- 2148 (34.01/12.27)	QHGAPGMQPPPQQGI
 2152- 2166 (27.13/ 8.19)	QQGGPTMYTGMQQGM
 2173- 2187 (23.57/ 6.07)	YGGQPGSQMVSQQQL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      84.91|      21|      22|     247|     267|       3
---------------------------------------------------------------------------
  224-  243 (26.41/12.21)	...SGSTGGNNTCTTSSATSGNN
  244-  266 (30.73/15.54)	AagGGSVTGASVNNGSSANTVVP
  267-  289 (27.77/13.26)	SgsGSSSTNTSVNTSTACSTIQP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     138.12|      21|      21|    2313|    2333|       5
---------------------------------------------------------------------------
 2089- 2112 (22.99/ 6.51)	NPKQA........LS.QML..RMRLPSNQylgTQQ
 2113- 2130 (24.60/ 7.55)	PPPGF........PQ.SIQ..RQQFIRQQ......
 2224- 2254 (24.27/ 7.34)	PPQQPrgageymgPQ.GGMtaQQRAMAVQ...QGA
 2312- 2332 (38.43/16.55)	QNQQF........QQ.QRM..RQQMMAQQ...QQS
 2333- 2354 (27.83/ 9.66)	NQQAP........ALvAHL..QRQLSQQQ...QQS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.25|      19|      20|    1185|    1203|       6
---------------------------------------------------------------------------
 1185- 1203 (36.48/27.13)	ETPNNR...YSFVCNAVVAVCN
 1204- 1225 (30.77/21.57)	ETDNDRlndLAITCAELTACCN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     263.89|      84|     273|     434|     522|       7
---------------------------------------------------------------------------
  434-  522 (149.87/86.40)	QGGPTQMVPVNPLMVTF..NE...YMSCP..HHRDLVLGLSAIL.QAITLDCPTALVWNC..VGEGKspsvLN.GSPL...DHLPCS..PSTlPMPQRAT..NPAVR
  696-  797 (114.02/55.88)	NGAPTGLPVFQPLLMRFldNDapvLEDNPsaQNRAMFTNLVHLFsELIRHDIFSHDVYMCtlISRGD....LNtGGPTmasSHHPTSnkPAT.PAESRGTvnNSGIQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.76|      20|      44|    1421|    1440|       8
---------------------------------------------------------------------------
 1421- 1440 (36.12/19.47)	PISGSSGGELS.ISHILGTSD
 1467- 1487 (30.64/15.42)	PIASSVGGTAStMETAAGLSD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.78|      12|      43|    1489|    1500|       9
---------------------------------------------------------------------------
 1489- 1500 (22.57/11.35)	AQHVLRQICSQE
 1529- 1540 (24.21/12.66)	AQRLLHMICYPE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.60|      13|      16|     799|     814|      10
---------------------------------------------------------------------------
  799-  814 (17.32/18.83)	DDGSlfpGIDLKPSKL
  818-  830 (24.29/14.83)	DHGR...NMDYDDSKI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      74.05|      15|      15|    1974|    1988|      11
---------------------------------------------------------------------------
 1974- 1988 (25.51/ 8.21)	QSPRGPGGNKRPKAQ
 1991- 2005 (25.08/ 7.94)	RRPKAGGPSAPSNGQ
 2299- 2311 (23.46/ 6.94)	QVPQP..PHATQQQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.24|      13|      15|    1090|    1103|      12
---------------------------------------------------------------------------
 1090- 1103 (21.86/15.50)	CrVVKHVTN.PGDCS
 1108- 1121 (21.38/10.08)	C.VLAHLYDlYSSCS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.59|      19|      20|     593|     612|      13
---------------------------------------------------------------------------
  593-  612 (28.45/22.49)	GTKES.SLTGTScGNNSNTSN
  614-  633 (30.14/17.35)	GSNSTvSNNGTS.GGDPLREN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     110.21|      32|      45|    1582|    1620|      14
---------------------------------------------------------------------------
 1561- 1580 (24.73/ 8.50)	.......NLDQW..T..LRM..SWLD...LQLMFTQ....
 1582- 1613 (57.50/44.76)	P..PGSSELNQWLDT..VAK..AAID..VFQLTTGGVSSG
 1626- 1661 (27.98/ 7.93)	PskPGSI....WLVAplVSKlpSAVQgrVLKVAGQVLESG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.49|      15|      20|     309|     323|      16
---------------------------------------------------------------------------
  309-  323 (28.71/13.62)	DQKLAQRQ..WQYCIQL
  329-  345 (20.79/ 8.15)	EEGLLERQefLQWILEL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      74.23|      17|      39|    1744|    1760|      18
---------------------------------------------------------------------------
 1744- 1760 (27.27/17.70)	FSLVGGMFDTIQRNTAV
 1769- 1785 (22.09/12.87)	VQLISYAVIDLNNNSEL
 1786- 1802 (24.87/15.46)	FTTVIDMLATLIHSTLV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.45|      18|      20|     374|     391|      19
---------------------------------------------------------------------------
  374-  391 (30.01/18.00)	VHSELLARKLAYFCAKKL
  397-  414 (27.44/15.79)	VASDTAAVSMAFSSSPAL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      38.93|      11|      47|    1889|    1903|      21
---------------------------------------------------------------------------
 1889- 1903 (17.24/17.95)	SPWDLLeghkNPAPL
 1937- 1947 (21.70/10.43)	SPAYFL....DPPPL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     249.23|      77|     113|     897|     974|      22
---------------------------------------------------------------------------
  897-  974 (128.18/84.10)	LPLDEPCSF.HDCNQRHVLLYG.......VGKIRDEARHTIKKITKELCRLFSKKFSIDVSeGAKLKKHSRVEFSFEATTAKVQGL
 1005- 1089 (121.06/75.15)	LPVQEHVAFlFDLMELAFNIYGlidvciqILKELPEIEAHLQGKQSTLMRSYTTSLSLYVV.GVLRRYHCCLLLSPEQTTAVFEGL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.21|      15|     296|    2060|    2074|      25
---------------------------------------------------------------------------
 2060- 2074 (29.10/12.53)	QQQQQQGYYSSQQLP
 2358- 2372 (33.11/15.37)	QQNQQHNPYSHQPPP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP00815 with Med12 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AREGKTPSSKNKPEQSQQMHSSSTGSCSNKPPIS
2) KESSLTGTSCGNNSNTSNNGSNSTVSNNGTSGGDPLRENRAD
3) LDKLLQHIKEEQQNSLDAPDSPKDDGVPPGSLVAPPMASVTPVERA
4) NGSPLDHLPCSPSTLPMPQRATNPAVRRQLRAAEDHVRN
5) NTGGPTMASSHHPTSNKPATPAESRGTVNNSGIQDDDGSLFPGIDLKPSKLDVQDHGRNMDYDDSK
6) PAYFLDPPPLPPEELDPPQEKPLKDDGKADTPNSSDQSPRGPGGNKRPKAQRRRRPKAGGPSAPSNGQPVMPGMPQQVQQPPQPPVPHLTYANQGGMFPTQSQWSYSQQQQQQQQQQQQQQQQQQQQQGYYSSQQLPAVGGPRFERPLNQSNPKQALSQMLRMRLPSNQYLGTQQPPPGFPQSIQRQQFIRQQLRAQHGAPGMQPPPQQGIFPQQQGGPTMYTGMQQGMNQNYAGYGGQPGSQMVSQQQLMGHAGQGMMGGFPGQQGGGFVSQQQAPGMMGSGGPIPPQQPRGAGEYMGPQGGMTAQQRAMAVQQGARPPYLQAPNVTMTTMGGPMGQQGQGQPQAAPPYGRAGGGGPGGTQVPQPPHATQQQQQNQQFQQQRMRQQMMAQQQQSNQQAPALVAHLQRQLSQQQQQSGGNQQNQQHNPYSHQPPPY
7) YGSGGTANTANNSGSTGGNNTCTTSSATSGNNAAGGGSVTGA
1390
595
834
496
764
1938
212
1423
636
879
534
829
2373
253










Molecular Recognition Features






MoRF SequenceStartStop




1) MMGFSYEKRALKRPRL
2) PALVAHLQRQLSQ
3) YYSSQ
1
2337
2067
16
2349
2071