<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP00810

Description Mediator of RNA polymerase II transcription subunit 13 (Fragment)
SequenceSEWGAEWEHHAQTRALILCTFRILLLPSPARLVIHPLLSLTSSLPLGPLLPLPPGTPITLLPSGTPAYYLSTYTGPTSGLITQFNESLVGQGIVGWDKDIVTRQGKQPMGRDTASHPPVFIIAWISVENKQGEEKGLPIVWPTCLCISSSLSNNGNGPRMLSYIPELPAELQPSPPPAARATSESGLASGLFSPSSGALTPFISALSPAVEHFPPQFTFDATSRATYHMSPSIASSPYSESLLSFRNLTVSRSKKVPQVAGEVGEYVDYVARERERERDRIRKERESQSHSSPKQSRRTPNTPTTIPTGTSSTGDFPATTITLTMPQSGTISASGTEPPPNHPPPHISIGSFYPSPPQTNPPVPLVAVSETSPEVVPTALPVSTQGTPIESQLPPSPGPQTNNAASGMNSFGSFGNIDMSWSEPVQTTDNDFLDMNIGFDLSMGFDMDMEPQSASNNTAAVTNYRRADMEMEEDFTEDDFSYFDSKPLKPSNSLPANLLSDASSAAALDPLASSGLGHWTPSLFGDLSFSGPGPPQSSPTSKAFGINIPQWNDGLNGRFGDAEPTPALSPPSAGRSPLSHGGPPTPDVQLDESTALSYNADPKHVTSSFDPIPFAERHKLADGKYAIGKFAPHISGDDPVAEEEVPPKGWKSKYKAATDPRVGLVRKLIGVKRKSNRQDRWPSKMSTKEHEDWSTKYDTDGDVEVEDSEVDSQDGEVEEVDTASVTTRASTPPPSYLPLGHSLLHTQFHHSQLLPLSSSLRPPSSVVAPANISAGPGATFVPTPVSPGAALGAANEKSKSLEAAALMIAKEVVDNGEWALCWFANVQATAHLQQAEARHADIHFIAHLLSRLPNVQGPMELTDLFSPTTPSTSPERVLQPTESPLITLAKGDTLVHIQPTAIAFWEKLGLGPKGGKKDVTAYALFQEVDESHRSSVANWLRNLSSEYTDKHLGCHEPGQGIGPEKNGLLSIQFDSTFRKNLANIVANLPPVNHSLVFYVVAPIMVMTLSSQLCRQDTAITLARSSVRTKYSITHCFDVVDRDTLLHVGYRISSCGKWILVACVDQRGEAYDTHLWLRHTPGEDGSPDDGTEVNDMSSEAYVALKVWSFASEFAKRANIEWRIIITKLGCLSESELQAWSSHLETTTESQADHVSLLCAYTDTSYKFLPPQATSPVKKPRQSRGTNASLFVDISANTYILYPQVVLPVIPPSLLPNVSMVTEPAQDEDDLESPPMFPLSTSILIRAPNEGGLASASMLQVHLLYTYQANDDADDAAEQQKRLMEDISRNLVDLTVLAKNRWMRIANPILPFHLAAVENMDRALTREEEPEEPACSDS
Length1336
PositionKinase
OrganismPleurotus ostreatus PC15
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Agaricomycotina> Agaricomycetes> Agaricomycetidae> Agaricales> Pleurotaceae> Pleurotus.
Aromaticity0.07
Grand average of hydropathy-0.348
Instability index57.32
Isoelectric point5.13
Molecular weight144713.55
Publications
PubMed=24958869

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP00810
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      77.92|      17|      18|     175|     192|       2
---------------------------------------------------------------------------
  175-  191 (28.11/ 9.33)	PPPAARATSESGLASGL
  194-  210 (25.97/ 9.48)	PSSGALTPFISALSPAV
  361-  375 (23.84/ 6.02)	PPVPLVAVSET..SPEV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      78.64|      17|      18|     595|     611|       3
---------------------------------------------------------------------------
  577-  592 (26.35/13.17)	PLSHG.GPPTP.DVQLDE
  595-  611 (30.07/16.25)	ALSYN.ADPKHVTSSFDP
  615-  632 (22.22/ 9.74)	AERHKlADGKYAIGKFAP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     362.13|     101|     807|       2|     157|       4
---------------------------------------------------------------------------
    2-  110 (178.05/107.27)	EWGAEWEHHAQTRAlilctfriLLLPSPARLV.IHPLLSLTSSLP..LGPLLP.......................................LPPGTPITLLPSGTPAYYL..STYTGPT.SGLIT...............QFNESLVGQ........GIVGWDKDIVTRQGKQPMG
  161-  279 (69.59/102.52)	.....................................LSYIPELP...AELQPspppaaratsesglasglfspssgaltpfisalspavehFPP..QFTFDATSRATYHMspSIASSPY.SESLL...............SFRNLTVSRskkvpqvaGEVGEYVDYVARERERERD
  817-  921 (114.49/50.72)	EWALCWFANVQATA........HLQQAEARHAdIHFIAHLLSRLPnvQGPMEL....................................tdlFSPTTPST.....SPERVL..Q....PTeSPLITlakgdtlvhiqptaiAFWEKL.GL........GPKGGKKDVTA........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     183.45|      44|     220|     506|     573|       5
---------------------------------------------------------------------------
  380-  412 (52.71/12.69)	LPVSTQGTPIESQLPP...SPGPQTNNAASGMNS.FG.............
  527-  573 (74.37/61.06)	LSFSGPGPPQSSPTSK...AFGINIPQWNDGLNGRFGdaEPTPaLSPPSA
  754-  790 (56.36/15.27)	LPLSSSLRPPSSVVAPaniSAGP.........GATF...VPTP.VSPGAA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     149.87|      45|     435|     685|     738|      10
---------------------------------------------------------------------------
  685-  738 (72.40/52.02)	MSTKEHEDWSTKYDTdgdvevedsEVDSQDGEVEEVDTASVTTRASTPPPSYLP
 1130- 1174 (77.47/40.48)	LSESELQAWSSHLET.........TTESQADHVSLLCAYTDTSYKFLPPQATSP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP00810 with Med13 domain of Kingdom Fungi
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