<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP00753
Description |
Mediator of RNA polymerase II transcription subunit 4 |
Sequence | MLSHQIVQSPARLGLTNPNSPLQNATPPKFPSSSSQQLPTPQQQQLQQHPSNPATTSTSSALLSLLPPLRRAQSLLLQMASLASKFFEVSPNRAFWLSAFRGSLPTFLSSQTQSMAPPPLESTPTSTKEVLSLFTSLQTQLFEAVAELQEILDLQDAKQRLAREIKSKDSALLNFANKLKEAERVLDMLVDDYSDYRRPKRAKSKLSADVPEDDDVSNTTVASQLELSDILSYAHRISYTTFAPPEYGAGQVPLRGALPPAPQEEQMRASQLYAFADLDVGLPKKIETKEKTIEAIIELPPPAQPAETNPFANFPAIQGLLPTNITVPSGWKPGMPVELPTNLPPPPPGWKPGDPLPPLESLPLPRMVEQQLQPVAPQGLHKPPETIQVRHVQIDILDQDDDSSDYSSEEGSSDDED |
Length | 417 |
Position | Middle |
Organism | Jatropha curcas (Barbados nut) |
Kingdom | Viridiplantae |
Lineage | Eukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta>
Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae>
rosids> fabids> Malpighiales> Euphorbiaceae> Crotonoideae> Jatropheae>
Jatropha.
|
Aromaticity | 0.06 |
Grand average of hydropathy | -0.483 |
Instability index | 72.49 |
Isoelectric point | 4.83 |
Molecular weight | 45717.05 |
Publications | PubMed=24837971
|
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364141
|
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP00753
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
5| 234.91| 42| 43| 298| 339| 1
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10- 49 (46.57/15.59) ...PARL.......GLTNPNSPLQNATPPKFPssSSQ....QL.PTP..QQQQLqqH
50- 101 (48.96/16.76) PSNPATTstssallSLLPPLRRAQSL.LLQMA..SLAskffEVSPNRAFWLSAF..R
298- 332 (55.91/20.17) ..............ELPPPAQPAETNPFANFP..AIQ....GLLPTNITVPSGW..K
333- 351 (32.49/ 8.68) PGMPVEL.....ptNLPPP...............................PPGW..K
352- 382 (50.97/17.75) PGDPL...............PPLESLPLPRM...VEQ....QLQP...VAPQGL.hK
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 111.71| 38| 44| 157| 200| 2
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157- 200 (55.40/51.12) AKQRLAREIKSKD.......SALLNFANKLKEAERVldmlvdDYSDYRRPK
202- 246 (56.32/38.01) AKSKLSADVPEDDdvsnttvASQLELSDILSYAHRI......SYTTFAPPE
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