<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP00745

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMAELGQQTVQLSTLVSRAAEESFLSLKELVEKSKSTNQSESEKKINLLRYLVKTQQRMLRLNVLAKWCQQVPLIQYCQQLQSTLSNHDACFTQAADSLFFMHEGLQQARAPIYDVPSAIEVLLTGSYQRLPKCLEDVGMQSSLTEEQQKLALKKLDTLVRSKLLEVTLPKEISEVKVSDGTALLVVEGEFKVLVTLGYRGHLSMWRILHLELLVGERSGLVKLEELQRHILGDDLERRMAAAENPFMLLYSVLHDLCISLIMDTVIRQVQTLRQGRWKDAIRFELITEGSTGSGQLNQDGETDYTGGMRTPGLKIMYWLDLDKNSGATDSGTCPFIKIEPGPDLQIKCVHSTFVVDPKNDREAEFSLDHSCIDVEKLLLRAICCNRYTRLLEIQKELVKNAQIFRVAGDVVLQSLMDNPDVDSKKKESKNDGRDYEGQEALCVRAYGSSFFTLGINTRNGRFLLRSSHRLLMPVVLIEYEEALNQGSTTAAEVFINLRSKSILHLFASIGRFLGLKVYEHGFTIVKVPKNLMNSSTMLLMGFPDCGSSYFLLVQLDKDFKPLFKLLETQPDSSGKSHSFNDSNHVMRIKKIDVSQMQMLEDELNLSLFDLGKLNGFLPNAGGSIQTSEHGLLSEFSLEGPMQIAGCPPSSFSSVVDEVFELEKGASAPSFPLQNHTSFNASSASRFGSVPMNLHSAKAGTPSPKWEGGLQVSQMNNVVKVSSAASNYNGSLYPSNNMRGPIHSNSFCSLSSGLGRSATVKKLPASKSDQDLTSLRSPHSIEVSSNSSVDEDHARLLNDMSMDVLSGSRSSRLLSPTQSTGSRASTPSAKPNALRSSPTGTLAGSIRITGSSSLVTTPVSQAAGDTAYHGSGHNVSKPDKNPRKRTVSDVLNLIPSLQDIDTKEGFSKRRRTTESLVSQQHSSQMLISSEIAFKNEGYSYGNLIAEANKGNAPSSIYVSALLHVVRHCSLCIKHARLTSQMEALEIPYVEEVGLRNASSNIWFRLPFARGDSWQHICLRLGRPGSMYWDVKINDQHFRDLWELQKGSSTTPWGSGVRIANTSDVDSHIRYDPEGVVLSYQSVEADSIKKLVADIRRLSNARMFALGMRKLLGVRPDEKSDESSLISDVKVSVGGKTGLEAADKLSEQMRRAFKIEAVGLMSLWFSFGTGVLARFVVEWESGKEGCTMHVSPDQLWPHTKFLEDFINGAEVASLLDCIRLTAGPLHALAAATRPARAGPSPGVPGVTSAIASMPKQAGYVQSQGVLPGSSTNNVSQPTSGSIVNSVASTGTGPLGNHNLHGPAMLASAGRGGPGIVPSSLLPIDVSVVLRGPYWIRIIYRKNFAVDMRCFAGDQVWLQPATPPKEGHKAGGSLPCPQFRPFIMEHVAQELNGLDSGFAGGQQTVGLASSNTANPGAGSQLSGANGNRVNMPSSAALSRAANQVAALNRVGNAVPGSSNLAVVSSGLPIRRSPGAGVPAHVRGELNTAIIGLGDDGGYGGGWVPLLALKKVLRGILKYLGVLWLFAQLPDLLKEILGSILKDNEGALLNLDQEQPALRFFVGGYVFAVSVHRVQLLLQVLSVKRFHHQQQQQQQQNSVTSQEELNQSEIGEICDYFSRRVASEPYDASRVASFITLLTLPISVLREFLKLIAWKKGLTQVQGGEIAPGQKPRIELCLENHAGLNENENSENSSAAKSNIHYNRPHNSVDFALTVVLDPAYIPHVNAAGGAAWLPYCVSVRLRYSFGENTNVTFLGMEGSHGGRACWLRADDWEKCKRRVIQTVEVNGCSTGDVTQGRLRMVADSVQRTLHLCLQGLRDGVVSASSGAT
Length1825
PositionTail
OrganismJatropha curcas (Barbados nut)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> fabids> Malpighiales> Euphorbiaceae> Crotonoideae> Jatropheae> Jatropha.
Aromaticity0.06
Grand average of hydropathy-0.199
Instability index42.52
Isoelectric point8.25
Molecular weight198931.17
Publications
PubMed=24837971

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP00745
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      73.54|      20|      21|     808|     827|       1
---------------------------------------------------------------------------
  808-  825 (24.45/11.68)	...RSSRLLS.PTQS.T..GSRAST
  826-  848 (20.71/ 8.57)	PSaKPNALRSsPTGTlA..GSIRIT
 1266- 1287 (28.37/14.93)	GS.STNNVSQ.PTSG.SivNSVAST
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      76.86|      22|      70|    1221|    1244|       2
---------------------------------------------------------------------------
 1221- 1244 (38.26/28.65)	GPL..HALAAATRPARAGpsPGVPGV
 1290- 1313 (38.60/21.91)	GPLgnHNLHGPAMLASAG..RGGPGI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      91.19|      27|      70|     927|     956|       3
---------------------------------------------------------------------------
  927-  956 (42.27/32.09)	SSEIAFK...NEGYSYGNLIAEANKgnaPSSIY
  997- 1026 (48.93/28.96)	SSNIWFRlpfARGDSWQHICLRLGR...PGSMY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.24|      20|      70|     451|     473|       5
---------------------------------------------------------------------------
  451-  473 (31.78/27.02)	FTLGINTRNgrfLLRSSHRLLM..P
  522-  543 (32.46/18.35)	FTIVKVPKN...LMNSSTMLLMgfP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.35|      19|      22|    1414|    1434|       7
---------------------------------------------------------------------------
 1414- 1434 (28.95/26.48)	AGSQLSGAN..GNRVnmPSSAAL
 1437- 1457 (27.40/16.74)	AANQVAALNrvGNAV..PGSSNL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      85.07|      20|      25|     596|     620|       8
---------------------------------------------------------------------------
  596-  615 (35.46/18.33)	MQMLEDELNL..SLFDLGKLNG
  624-  639 (27.71/21.32)	IQTSEHGL.L..SEF...SLEG
  884-  904 (21.91/ 9.60)	.RTVSDVLNLipSLQDIDTKEG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.85|      19|      22|     765|     786|      10
---------------------------------------------------------------------------
  768-  786 (32.53/23.56)	DQDLTSLRSPHSIEVSSNS
  789-  807 (33.33/15.82)	DEDHARLLNDMSMDVLSGS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      72.27|      21|      22|     705|     725|      12
---------------------------------------------------------------------------
  705-  725 (35.90/20.90)	WEGGLQVSQ.MNNVVKVSSAAS
  727-  748 (36.38/21.28)	YNGSLYPSNnMRGPIHSNSFCS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     109.22|      35|     261|    1464|    1499|      13
---------------------------------------------------------------------------
 1464- 1499 (65.11/43.56)	LP.IRRSPGAG.VP..AHVR.....GElNTAIIGLGDDGGYGG..GW
 1718- 1763 (44.10/24.02)	IPhVNAAGGAAwLPycVSVRlrysfGE.NTNVTFLGMEGSHGGraCW
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP00745 with Med14 domain of Kingdom Viridiplantae
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