<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP00634

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMLRLNVLAKWCQQVPLIHYSQQLASTLSSHDTCFTQAADSLFFMHEGLQQARAPIYDVPSAIEVFLTGSYQRLPKCIEDMGMQSTLTKDQQKAALKKLDTLVRAKLLEVSLPKEISEVKVSSGTALLRVDGEFKVLVTLGYRGHLSMWRILHLELLVGERSGPVKLEESRRHVLGDDLERRMSAADNPFITLYSILHELCVALVMDTVIRQVQALRQGRWKDAIRFELISDGSMGHGASGSSIQPNQDGEVDSAGLRTPGLKLIYWLDFDKNPGSSDSGSCPFIKIEPGPDLQIKCLHSSFVIDPLTGKEAEFALDQSCIDVEKLLLRAISCNRYTRLLEIQKELGKNIQICRAPSDVVLQSFMDELDADNRKKDNKSEFRDYEGQEVLRVRAYGSSFFTLGINIRNGLLSDCEEALNQGSTSAAEVFISLRSKSILHLFAAIGRFLGLEVYDHGFASMKVPKNLVNGSTVLLMGFPDCGSSYFLLMELDKDFKPMFKLVETQPDQSEKGQSSSDLNRVIRIKQIDISQMQILEDELNLSILNQGNLLSVMPNADGANHTSEQGLISEFNLDGSMHIAGCPLSSFSSVVDEVFEFEKGPAASSYTLQNVSSSFTTSSASHFGSLQMNLHGVKAGTPSPRWEGGVQMSHLNVAKGSIGNTQYNGSLYSSSNVKGPVQSSSFSSLSSGLARSTAVKKLPASKSDQDLASLRSPHSIEIGTVEEDLVSVGRSSRLLSPPRTASVRAPPPSAKPNGPRSSVTGSLAGSIKVAGSSSLASPPVSHAADTDIVSKHDKHPRKRTVSDMLSLIPSLQDIEAATGLSNKRRKISESAHFQQPLSGGLISAEIVSKAERYSYGNLVAEANKGNAPSSTYISALLHVVRHCSLCIKHARLTSQMELLDIPYVEEVGLRSASSNIWFRLPFARGYTWRHICLRLGRPGSMHWDVKINDQHFRDLWELQKGSNSTPWGSGVRIANTSDIDSHIRFDPEGVVLSYQSVEDDSIKKLVADIQRLANARMFALGMRKLLGVRADEKPEEGTANFDVKAPVGGKGASEASDKLSEQMKRAFRIEAVGLMSLWFSFGSVVLARFVVEWESGKEGCTMHVSPDQLWPHTKFLEDFINGAEVASLLDCIRLTAGPLHALGAATRPARAGTGPGVPGVATAVSTIPKQTGYSSSQGLLPNGSTTNVSQVTSAPTGLNVSQVTSASTGNPVGAASTVPLGNPNLHGAAMLAAAGRGGPGIVPSSLLPIDVSVVLRGPYWIRIIYRKHFAVDMRCFAGDQVWLQPATPPKGGPSVGGSLPCPQFRPFIMEHVAQELNGLDSNITGGQQTVGMANTNPSSGSQLASANGSRVNIPSSAAMSRAVNQVAALNRVGNPMPGSSNLSVVSSGLPIRRSPGASVPAHVRGELNTAIIGLGDDGGYGGGWVPLVALKKVLRGILKYLGVLWLFAQLPDLLKEILGSILKDNEGALLNLDQEQPALRFFVGGYVFAVSVHRVQLLLQVLSVKRFHQQQQQQQQQNSSTAQEELTQSEIGEICDYFSRRVASEPYDASRVASFITLLTLPISVLREFLKLIAWKKGLAQTQGGEIAPSQKPRIELCLENHSGFNVDDGSVNSSASKSNIHYDRPHNSVDFALTVVLDPAHIPHINAAGGAAWLPYCVSVRLRYSFGENPNVSFLGMEGSHGGRACWLRTDEWEKCKQRVARVVEVNPVSAGDLTQGRLRIVADSVQRTLHMCLQGLKDGGTVTASSVGV
Length1749
PositionTail
OrganismCitrus sinensis (Sweet orange) (Citrus aurantium var. sinensis)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> malvids> Sapindales> Rutaceae> Aurantioideae> Citrus.
Aromaticity0.06
Grand average of hydropathy-0.151
Instability index45.69
Isoelectric point7.90
Molecular weight189262.14
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
core mediator complex	GO:0070847	IBA:GO_Central
mediator complex	GO:0016592	IBA:GO_Central

GO - Biological Function
transcription coregulator activity	GO:0003712	IBA:GO_Central

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP00634
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     426.34|     108|     256|    1284|    1422|       1
---------------------------------------------------------------------------
  573-  687 (104.77/39.52)	.....GSMHIAG...CPlsSFS.SVVDE..VFEFEK..GPAASSYT..LQNVSSSFTTSSAshfGSLQMNLHGVKAGTPSprwegGVQMSH.LN..VAKGSIGNtqyngslysssnvkgPVQ.SSSFSSLS..SGL....
  690-  797 (135.24/52.89)	STAVKKLPASKSDQDLA..SLRsPHSIEigTVEEDLvsVGRSSRLLSPPRTASVRAPPPS........AKPNGPRSSVTG.....SLAGSIKVAGSSSL..ASP...............PVSHAADTDIVSkhDKHPRKR
 1284- 1391 (186.33/118.09)	ATPPKGGPSVGGSLPCP..QFR.PFIME..HVAQEL..NGLDSNITGGQQTVGMANTNPSS...GSQLASANGSRVNIPS.....SAAMSRAVNQVAALNRVGN...............PMPGSSNLSVVS..SGLPIRR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      70.79|      19|     256|    1394|    1422|       2
---------------------------------------------------------------------------
 1403- 1422 (34.51/36.30)	GElNTAIIGLGDDGGYGG..GW
 1666- 1686 (36.28/14.08)	GE.NPNVSFLGMEGSHGGraCW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      84.16|      25|     256|     116|     140|       3
---------------------------------------------------------------------------
  116-  140 (40.09/23.70)	SEVKVSSGTALLRVDGEFKVLVTLG
  378-  402 (44.06/26.75)	SEFRDYEGQEVLRVRAYGSSFFTLG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     116.03|      36|     256|     244|     316|       4
---------------------------------------------------------------------------
  261-  304 (57.78/81.33)	LKLIYWldfDKNPGSSDSGscpfiKIEPGPDLQIK.CL..HSSFVID
 1568- 1606 (58.25/16.85)	LKLIAW...KKGLAQTQGG.....EIAPSQKPRIElCLenHSGFNVD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.59|      18|     256|     546|     568|       5
---------------------------------------------------------------------------
  549-  568 (27.77/25.54)	SVMPNADGanHTSEQGLISE
 1163- 1180 (32.82/14.37)	STIPKQTG..YSSSQGLLPN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     266.44|      72|     164|     889|     961|       8
---------------------------------------------------------------------------
  889-  961 (130.76/98.69)	RLTSQMELLDIPYVEEVGLRSASSNIWFRLPF.....AR.GYT..WRHIC.LRLG.RP..G.SMHWDVKiNDQ...HFRDLWELQKGSN
  982- 1042 (56.70/35.51)	RFDPEGVVLSYQSVEDDSIKKLVADIQ.RLAN.....AR.MFAlgMRKLLgVRADeKPeeG.TANFDVK....................
 1056- 1122 (78.97/53.31)	KLSEQMK..RAFRIEAVGLMS....LWF..SFgsvvlARfVVE..W......ESG.KE..GcTMHVS...PDQlwpHTKFLEDFINGAE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.88|      13|      45|    1149|    1161|      11
---------------------------------------------------------------------------
 1149- 1161 (26.63/14.46)	AGTGPGVPGVATA
 1192- 1204 (20.25/ 9.02)	APTGLNVSQVTSA
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP00634 with Med14 domain of Kingdom Viridiplantae
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