<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP00618

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMEGLPAVEPVELRDLVARCVDKSYENFRGLAHGLGGVAKAEERREQALKHLADTRSLFEKLLVLTRWSVQSPLAAQCAELLKTAKLFTDQLNESNDRLFFLHADLNRAKERTYDLATAIDVLYGGTYPRLPKLISYAMHPKEMPDVDEDKAIQEMDDIIRFRLIEEEIPSTFTRIDVEGGFVIAHVEGEFEIVFTLNGKESDSLWRLVAINTVLTDAAATEKYKTLASTNTLRIIKANAPTELHYMHMRNLVQKCMNKSSAPFVAACDIMRDFCCSLSLQILVAQGHLLTDSRWKSSNVEFVYHADKQVLDICYWSSFCRPAVLTTEAAQLAAEMADKFKKPESESLPPYPTASLCVRLYSDPKHHDLLSLSLHPPPAPELRASLSDALVVPRNMYGLSAEAFLMGGMRMHVASALFCLERHLVLGTGASTPLHLTTSEAVHIVRTERSIHIARADSGGLAQYQLEISFDSPLVDGVVRGLETLLQRSVKAQLGPHGFSLAIDDLKAVADAVSACLREMLAYEISEVASSFANIEVHRHVSVNWDRYIAFRRQQGNNVDALSISPNALFFQIVRNKESCGYLVVEIDREAEYESSTDVHYVENADDWIRVPAFSLLQLSSSAGAPSAVQFFQRFPAFRKDALAPMMPPPTKKQKTASSTPPLAPLFLHVVSLCHERIQLQHYVNFAKRRRVRIRYAGQGGTASAAHQSGEQIVSFPFPERVSSAPMEIRAVHGHLRKGGGFEMCVQLASPPFTFLIPNDFFGALHIGDHHALPNSNLIFRYPPTTKLQPDNPLETFIADLLMNVKPMCEFGVKLEKTLSSLGRYGPDVDVRDHFIVERADPFSIVLACRTSNPKRCVAAGSTPDDTITYRIMVQFKPKGGFILTSSHRGEHPLLQFIQAALNVHNDSAQLLEALERTTIPLAILSSVVSSQVISAKCYRHDSGPRREGGGSLGGKKGGGKGLRFGYKGKLPGEEKGYYAERTYGGDDRSFVPADLLLIPRSQNHIRLTYADRCGIDVFFMENETVTIKSAPCGARVPSCAVDGGLSVSHATFGERLRNLVFPEMASL
Length1067
PositionTail
OrganismSaprolegnia parasitica (strain CBS 223.65)
KingdomOomycetes
LineageEukaryota> Sar> Stramenopiles> Oomycota> Saprolegniales> Saprolegniaceae> Saprolegnia.
Aromaticity0.08
Grand average of hydropathy-0.137
Instability index46.00
Isoelectric point6.70
Molecular weight118236.04
Publications
PubMed=23785293

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP00618
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      83.32|      24|      79|     621|     645|       1
---------------------------------------------------------------------------
  621-  645 (39.42/30.39)	SAGAPSAVQFFQrFPAFRKDALAPM
  703-  726 (43.90/28.88)	SAAHQSGEQIVS.FPFPERVSSAPM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     377.52|     124|     234|       6|     145|       2
---------------------------------------------------------------------------
    6-  145 (191.60/148.99)	AVEPVEL.....RDLVARCVDKSYENFRGLAHGLGGVAKAEERR.EQALKHladtrslfekLLVLTRW...SVQSPLAA..Q....C..AELLKTAKLFTD..QL.NESNDRlfFLHADLNRAKerTYDLATAIDVLYggTYPRLPKLISYAMHPKEMPD
  237-  380 (185.92/112.12)	ANAPTELhymhmRNLVQKCMNKSSAPFVAACDIMRDFCCSLSLQiLVAQGH..........LLTDSRWkssNVEFVYHAdkQvldiCywSSFCRPAVLTTEaaQLaAEMADK..FKKPESESLP..PYPTASLCVRLY..SDPKHHDLLSLSLHPPPAPE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     117.38|      33|     133|     647|     680|       5
---------------------------------------------------------------------------
  647-  679 (60.00/34.21)	PPPTKKQKTASSTPPLAPLFLHVVSLCHERIQL
  782-  814 (57.38/32.25)	PPTTKLQPDNPLETFIADLLMNVKPMCEFGVKL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP00618 with Med14 domain of Kingdom Oomycetes
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