<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP00614

Description Mediator of RNA polymerase II transcription subunit 17
SequenceMASGSSMPFSSLHPVPTGGRKPKSLGEFIARVQSERGFRNVTEESLKEEAEKQKNGDAEVKDEDTAMSDGNADDEEPPDAAAARMEVLRNIDVAQNAALMTLDFISLLLSKESPAQAGVTLSQALRDWTGIGTLGIAKREDNDEQKQRDAERAKDNHDVSLGWALLDIETTKQSADKAASHLSKEVEREAKYWDEVLSVHQAGWSMCRLPAERHTLGVRFGFSEGWCPPNFANRTASLTLPASPEFRNSSLAPLRRGDDGTALLQHGRVGAGSQRLSVTVSRSGETTGRLAIGSSVPDSALLPDHVLEARNTIFAQELWHELHREAHSLASYGVRANNETINFNPVSGPSLTLELETLDDGAPAVGESTDNVLAEATHLSLHILLSHAHRLNELQRLRPAPPHQRRNQAQNQYHLLRPIIAKILHDRSVEQVTRFAGDLTRVLRRAGVHAASFTLNTPPFPTADLKNTSRGASNRPNASQALTNMLTSPADFQVELTLTPTSRLQIRGRTFLLPLTTTQFQLQLLPSLAEPTGAEHAPSSLQASYPPSRDPYPDFSSVQLYLANAAAHALTDFAMSFVPPAPTQPSEPAYGEWSKSVRGTAIRDMDSETREIRFDVLSNDHEGRLTLQIGAAWRAGDKPLIKRWAWPAIGENAGKSATQPHVGDIVAAVVQSKEI
Length675
PositionHead
OrganismColletotrichum sublineola (Sorghum anthracnose fungus)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Glomerellales> Glomerellaceae> Colletotrichum> Colletotrichum graminicola species complex.
Aromaticity0.05
Grand average of hydropathy-0.475
Instability index45.69
Isoelectric point5.90
Molecular weight73675.41
Publications
PubMed=24926053

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP00614
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     378.09|     113|     118|     371|     485|       1
---------------------------------------------------------------------------
  301-  354 (40.29/18.61)	.........................................................LLPDHVLEaRNTIFAQELWHELHREahslasyGVRA.NNETIN.FNPV........................SGPSLTLE
  373-  485 (190.33/124.12)	LAEATHLSLHILLSHAHRLNELQRLRPAPPHQRRNQAQNQYHLLRPIIA.......KILHDRSVE.QVTRFAGDLTRVLRRA.......GVHA.ASFTLN.TPPFPT.......ADLKNTSRGASNRPNASQALTNM
  486-  608 (147.46/89.17)	LTSPADFQVELTLTPTSRLQIRGRTFLLPLTTTQFQLQLLPSLAEPTGAehapsslQASYPPSRD.PYPDFS.SVQLYLANA.......AAHAlTDFAMSfVPPAPTqpsepayGEWSKSVRGTAIRDMDSE.....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      49.21|      10|      16|     149|     158|       2
---------------------------------------------------------------------------
  149-  158 (17.01/10.58)	DAERAKDNHD
  167-  176 (15.31/ 8.81)	DIETTKQSAD
  185-  194 (16.89/10.45)	EVEREAKYWD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      34.05|      10|      16|      57|      66|       3
---------------------------------------------------------------------------
   57-   66 (16.45/ 8.11)	DAEVKDEDTA
   74-   83 (17.60/ 9.16)	DEEPPDAAAA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      27.08|       8|      19|     203|     213|       4
---------------------------------------------------------------------------
  203-  213 (10.89/15.07)	GWsmCRlP..AER
  225-  234 (16.19/ 7.16)	GW..CP.PnfANR
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP00614 with Med17 domain of Kingdom Fungi
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