<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP00613

Description Mediator of RNA polymerase II transcription subunit 5
SequenceMDGRVVRGVQRAALEQWSEFIAKSLSHRIDPEKFESYVPFLQAKHPLPPVAVADLFLRPQPHNHESLDPRVPRYLQVLSDLNYIDTASILKSLYRYSTSRAHSRDTTQPTTGEAQRSNLPRWGSSYAAEEVMFYRLTKSVAQGTAIQNTGTGLEIANIMAKWIALFTDAATAFTVDVMGQLHNSQVREEMESARAAFVALLLGVCENQVVLKALSKPEAQGTRKALSESLANFVPTIMQSAGPIATRLDMFRTSTLAGFEPVDEQKNKSNAEIEDLFDPTVALDNFVISELPIVNSRAGLYIYLNAALVGRPLIDDLAIFNYLNNRYQGDVQSTTVDLILASFDVLANAASRNEGNQAAHLLRSFLMNKLPILIESLSKHMYGPVNAEYCITEALGRVDTTTFPTLSSMFDETRSNNPFTDSVREEFCWACCLHGLVRESSIETLLGETPYQSLPAGGRYVKENLVAECLADQERMQALIGELDNKDGNAGAVCQALTEVMGQLCRNKETMSLKLLCSQLAQKPLSLDVMLMFEKPGTILHPLCDLLDNWKYDEDQGEYQPVYEEFGSILLLVMAFAYRYGLSASDMGVVSPDSFVAKLLGQGHQSRPLDELSDQEKGHLNGWIHGLFDSEAGGLGDELMSSCPPQDFYLLVSTLFQNIVLAFSTGHLAEESLRGGIEYLVDTFLLPSLVVAITYLANSLWVERSDCQKAIVRVLNSVLAPTSISNEAQAMLTSVMNIVAKPLEHSLRAYQRSDPKSQEVEPLLKAIKDSIPLSRRTGAADHTELDAWSLGGFSNSIRQTLQQLVQWSIHPTMDRMPPAYTHRQMLVALKLLGAKRLLQLLYEDIRQQTDTGSGSIIYDVATAIVCAPDVVNTPPNPVNFLDNSGNMPAPVQRKLTLREVLKSDAEDCKRLQKTDINLAEIVVRLHRKVESQMAVSQAQAIQADTMLQTDLGLGLDAGAGSLDDAMAAAAANVGQGDGMSVDNVSLDLGLGGVGGDMGLGGSSNNGGGSLDLGTDDIFGALGAGDDFQWDNMDLS
Length1035
PositionTail
OrganismColletotrichum sublineola (Sorghum anthracnose fungus)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Glomerellales> Glomerellaceae> Colletotrichum> Colletotrichum graminicola species complex.
Aromaticity0.07
Grand average of hydropathy-0.112
Instability index40.91
Isoelectric point4.85
Molecular weight113218.25
Publications
PubMed=24926053

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP00613
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.50|      16|      34|     933|     966|       1
---------------------------------------------------------------------------
  933-  960 (17.40/28.54)	MAVSQaqaiqadtmLQTDLGLGldaGAG
  979-  994 (30.09/11.00)	MSVDN.........VSLDLGLG...GVG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.89|      20|      26|     494|     517|       2
---------------------------------------------------------------------------
  496-  517 (30.86/29.80)	ALT......EVMgqLCRNKETMSLKLLC
  519-  544 (32.03/15.01)	QLAqkplslDVM..LMFEKPGTILHPLC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      76.90|      22|      25|     230|     253|       3
---------------------------------------------------------------------------
  230-  251 (39.24/26.36)	LANFVPTIMQSAGPIATRLDMF
  256-  277 (37.66/18.66)	LAGFEPVDEQKNKSNAEIEDLF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.86|      14|      26|     317|     330|       4
---------------------------------------------------------------------------
  317-  330 (26.83/16.71)	LAIFNYLNN...RYQGD
  340-  356 (17.04/ 8.01)	LASFDVLANaasRNEGN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      35.13|      12|      26|     686|     698|       6
---------------------------------------------------------------------------
  686-  698 (16.32/13.70)	LPSlVVAITYLAN
  715-  726 (18.81/10.29)	LNS.VLAPTSISN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.06|      19|      26|     439|     464|       8
---------------------------------------------------------------------------
  439-  457 (31.94/28.78)	ESSIETLLGETPYQSLPAG
  473-  491 (32.12/12.84)	QERMQALIGELDNKDGNAG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      76.28|      23|      26|     110|     132|       9
---------------------------------------------------------------------------
  110-  132 (39.65/27.71)	TTGEAQRSNLPRWGSSYAAEEVM
  137-  159 (36.63/25.00)	TKSVAQGTAIQNTGTGLEIANIM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      91.61|      20|      26|     610|     629|      10
---------------------------------------------------------------------------
  610-  629 (36.73/22.08)	DEL.SDQEKGHLNGWIHGLFD
  637-  657 (28.64/15.58)	DELmSSCPPQDFYLLVSTLFQ
  666-  682 (26.24/13.64)	GHL.AEE...SLRGGIEYLVD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      70.84|      23|      37|     375|     398|      11
---------------------------------------------------------------------------
  375-  398 (37.49/27.71)	ESLSKhMY..........GPVNAEYCITEAL.GRV
  404-  437 (33.35/19.17)	PTLSS.MFdetrsnnpftDSVREEFCWACCLhGLV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      92.52|      28|      32|      28|      55|      12
---------------------------------------------------------------------------
   28-   55 (50.89/35.48)	RIDPEKFES...YVP.FLQAKHPLPPVAVADL
   58-   89 (41.63/27.59)	RPQPHNHESldpRVPrYLQVLSDLNYIDTASI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.32|      16|      19|     741|     758|      14
---------------------------------------------------------------------------
  743-  758 (27.95/20.17)	LEHSLRAYQRSDPKSQ
  760-  775 (25.37/10.56)	VEPLLKAIKDSIPLSR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.85|      14|      37|     801|     814|      15
---------------------------------------------------------------------------
  801-  814 (24.94/14.55)	LQQLVQWSIHPTMD
  837-  850 (18.92/ 9.28)	LLQLLYEDIRQQTD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.92|      15|      32|     555|     571|      16
---------------------------------------------------------------------------
  555-  571 (23.12/19.14)	DQGEYQPvyEEFGSILL
  586-  600 (25.79/14.09)	DMGVVSP..DSFVAKLL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP00613 with Med5 domain of Kingdom Fungi
Unable to open file!