<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP00613

Description Mediator of RNA polymerase II transcription subunit 5
SequenceMDGRVVRGVQRAALEQWSEFIAKSLSHRIDPEKFESYVPFLQAKHPLPPVAVADLFLRPQPHNHESLDPRVPRYLQVLSDLNYIDTASILKSLYRYSTSRAHSRDTTQPTTGEAQRSNLPRWGSSYAAEEVMFYRLTKSVAQGTAIQNTGTGLEIANIMAKWIALFTDAATAFTVDVMGQLHNSQVREEMESARAAFVALLLGVCENQVVLKALSKPEAQGTRKALSESLANFVPTIMQSAGPIATRLDMFRTSTLAGFEPVDEQKNKSNAEIEDLFDPTVALDNFVISELPIVNSRAGLYIYLNAALVGRPLIDDLAIFNYLNNRYQGDVQSTTVDLILASFDVLANAASRNEGNQAAHLLRSFLMNKLPILIESLSKHMYGPVNAEYCITEALGRVDTTTFPTLSSMFDETRSNNPFTDSVREEFCWACCLHGLVRESSIETLLGETPYQSLPAGGRYVKENLVAECLADQERMQALIGELDNKDGNAGAVCQALTEVMGQLCRNKETMSLKLLCSQLAQKPLSLDVMLMFEKPGTILHPLCDLLDNWKYDEDQGEYQPVYEEFGSILLLVMAFAYRYGLSASDMGVVSPDSFVAKLLGQGHQSRPLDELSDQEKGHLNGWIHGLFDSEAGGLGDELMSSCPPQDFYLLVSTLFQNIVLAFSTGHLAEESLRGGIEYLVDTFLLPSLVVAITYLANSLWVERSDCQKAIVRVLNSVLAPTSISNEAQAMLTSVMNIVAKPLEHSLRAYQRSDPKSQEVEPLLKAIKDSIPLSRRTGAADHTELDAWSLGGFSNSIRQTLQQLVQWSIHPTMDRMPPAYTHRQMLVALKLLGAKRLLQLLYEDIRQQTDTGSGSIIYDVATAIVCAPDVVNTPPNPVNFLDNSGNMPAPVQRKLTLREVLKSDAEDCKRLQKTDINLAEIVVRLHRKVESQMAVSQAQAIQADTMLQTDLGLGLDAGAGSLDDAMAAAAANVGQGDGMSVDNVSLDLGLGGVGGDMGLGGSSNNGGGSLDLGTDDIFGALGAGDDFQWDNMDLS
Length1035
PositionTail
OrganismColletotrichum sublineola (Sorghum anthracnose fungus)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Glomerellales> Glomerellaceae> Colletotrichum> Colletotrichum graminicola species complex.
Aromaticity0.07
Grand average of hydropathy-0.112
Instability index40.91
Isoelectric point4.85
Molecular weight113218.25
Publications
PubMed=24926053

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364142
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP00613
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.50|      16|      34|     933|     966|       1
---------------------------------------------------------------------------
  933-  960 (17.40/28.54)	MAVSQaqaiqadtmLQTDLGLGldaGAG
  979-  994 (30.09/11.00)	MSVDN.........VSLDLGLG...GVG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.89|      20|      26|     494|     517|       2
---------------------------------------------------------------------------
  496-  517 (30.86/29.80)	ALT......EVMgqLCRNKETMSLKLLC
  519-  544 (32.03/15.01)	QLAqkplslDVM..LMFEKPGTILHPLC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      76.90|      22|      25|     230|     253|       3
---------------------------------------------------------------------------
  230-  251 (39.24/26.36)	LANFVPTIMQSAGPIATRLDMF
  256-  277 (37.66/18.66)	LAGFEPVDEQKNKSNAEIEDLF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.86|      14|      26|     317|     330|       4
---------------------------------------------------------------------------
  317-  330 (26.83/16.71)	LAIFNYLNN...RYQGD
  340-  356 (17.04/ 8.01)	LASFDVLANaasRNEGN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      35.13|      12|      26|     686|     698|       6
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  686-  698 (16.32/13.70)	LPSlVVAITYLAN
  715-  726 (18.81/10.29)	LNS.VLAPTSISN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.06|      19|      26|     439|     464|       8
---------------------------------------------------------------------------
  439-  457 (31.94/28.78)	ESSIETLLGETPYQSLPAG
  473-  491 (32.12/12.84)	QERMQALIGELDNKDGNAG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      76.28|      23|      26|     110|     132|       9
---------------------------------------------------------------------------
  110-  132 (39.65/27.71)	TTGEAQRSNLPRWGSSYAAEEVM
  137-  159 (36.63/25.00)	TKSVAQGTAIQNTGTGLEIANIM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      91.61|      20|      26|     610|     629|      10
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  610-  629 (36.73/22.08)	DEL.SDQEKGHLNGWIHGLFD
  637-  657 (28.64/15.58)	DELmSSCPPQDFYLLVSTLFQ
  666-  682 (26.24/13.64)	GHL.AEE...SLRGGIEYLVD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      70.84|      23|      37|     375|     398|      11
---------------------------------------------------------------------------
  375-  398 (37.49/27.71)	ESLSKhMY..........GPVNAEYCITEAL.GRV
  404-  437 (33.35/19.17)	PTLSS.MFdetrsnnpftDSVREEFCWACCLhGLV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      92.52|      28|      32|      28|      55|      12
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   28-   55 (50.89/35.48)	RIDPEKFES...YVP.FLQAKHPLPPVAVADL
   58-   89 (41.63/27.59)	RPQPHNHESldpRVPrYLQVLSDLNYIDTASI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.32|      16|      19|     741|     758|      14
---------------------------------------------------------------------------
  743-  758 (27.95/20.17)	LEHSLRAYQRSDPKSQ
  760-  775 (25.37/10.56)	VEPLLKAIKDSIPLSR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.85|      14|      37|     801|     814|      15
---------------------------------------------------------------------------
  801-  814 (24.94/14.55)	LQQLVQWSIHPTMD
  837-  850 (18.92/ 9.28)	LLQLLYEDIRQQTD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.92|      15|      32|     555|     571|      16
---------------------------------------------------------------------------
  555-  571 (23.12/19.14)	DQGEYQPvyEEFGSILL
  586-  600 (25.79/14.09)	DMGVVSP..DSFVAKLL
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP00613 with Med5 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




NANANA









Molecular Recognition Features






MoRF SequenceStartStop




1) LGAGDDFQWDNMDL
1021
1034