<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP00609

Description Putative transcription mediator subunit Med12
SequenceMGVQPRPPQQRTVSSSGLSVQRPTHQRTLSAQYLPQSPVRKETPIDLTGDANGAAVAQNRYGSLPRRGGSRLKLELSNDAMLAQHPITDSPKTLTPSRLMPKNDPSNLAEMGSPSSAKGQPIDADNPPMPMPKRRPRFVARPAAKDSPAPTVAIKKDGRPKAWHFETPAAAPRYAPFNKQRNDATNKPGFGGSGTGTRDASEIGYADFFPWNGNHPEDQYSETVIKTGYYDKPPASSASETSSAKAVLFPALKHKSGLNLLSSIFVGVLNQRKLNGQILSPSTFKPPPRVTLTDTKREMWLRDLANPSISLRRLSRTIPHGIRGKVLLDHCLNKNVPTERAVWLVKCVGANEIRAFKRKGNGPGPFVLGGEAKWLRDWTVFVEQFMEGVSTAFGDNDWKVKVQYAIRLATHLYAEQLLDRDHYMDWLVSGLENSTQSKLPMWILITQIYWKDLLRLRKYGRRLVNALLSHLHTIHNDPDRDILVQLSARLATLLTPLLSAHPDNFVSPATWFKYRDALLASIPTDHEFAQTAYKSINMRNEQLVASASNSQPANRQILVKHLDTTYTSLYSPDLAAQCWAVSEDKNMIVRTLLEWCTSPHRPGAAKVYITAGLLRAWVAVGVDVTTAVLEYLSSNPPTETNSKRVFHRLMSEIVRTGDFQLQGYIFWLIARGGLRRPADTEADGSCATRLLVDLPLHALNSTSRTTRSSLLRRASYDVKEEAEDINMAIKCIDHALGLPLQPGDPMLQRKPVPVGKLCRLIANSNRALQTEVGARLLQIFTTEIVMTKNGPQVSPAMFNFARAVLEAAADFSALAEIIKLVVRASNPEILASCADTINVHLPIFAALGGPKELFDLLMERLKVVSEEQGPAARPLLASLANLAARLPGFTNTASYLRQQLHQCDRNNPIDACSPVSDNMTAQLQDAEGELHEEIEKLLTSGTSVDRPTMDRLFQTVVGRLESSWSNSPDRQRAYSALLGRLRIFDTQHFDVRMTDWVHHISALKARPALVDIYPLLISMGCLTLPIVLTTTSIDAGRIALNPSGPTNSTTTYMQEVLHLTTMPLTAKTALTPEETYRFYIQQQVVPRQNHKDMVLLVRNALIEYSRLQGAADLALLPLADPSFMNSVLELLKFLVLRDPPSVVQALGTKTPEPALTNVFAQITSKLLLPDASDESPLTFETVLELANEFTLPFCQLKLSIGLSADSATSPGGGEQALTQFDMFSRAMDRAVSANNVMWTSMLPYLSEEITEHLKKQAHLRFLGLFPSQKNPPASDPLSLESIQLAGSLLSVVEAILRGRPAARTSQLTSGMVEKLAELWEILAAGDDDKRELQSSTLRYWLPALLRFITLHTTANEPMSAPAQVQVTNNMKPPVNAAAFEIRARILVILSGLTLELDALALQDPHTGRTLSQQVFDLALLLIDTLPEDSRLQCVRVLLTGGTMQNPASSDARLQYLFSHMPPQTEQFVLAHRQQTATQQQQTGPPRQKIPISMQGTGKITPFVYRKWEMLSEPTPNVGENDTALSLTLFEAIKIQ
Length1535
PositionKinase
OrganismColletotrichum sublineola (Sorghum anthracnose fungus)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Glomerellales> Glomerellaceae> Colletotrichum> Colletotrichum graminicola species complex.
Aromaticity0.07
Grand average of hydropathy-0.229
Instability index44.02
Isoelectric point8.91
Molecular weight169750.70
Publications
PubMed=24926053

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. Component of the srb8-11 complex. The srb8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The srb8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
ECO:0000256	ARBA:ARBA00002895
ECO:0000256	ARBA:ARBA00003744
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP00609
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     273.66|      95|     238|     865|     968|       1
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   77-  127 (50.57/21.49)	SNDAMLAQHPITDSPKTLTpSRLmP..KNDPSNLAEMGSPSSaKGQPIDADNP..................................................
  865-  964 (149.88/102.84)	SEEQGPAARPLLASLANLA.ARL.PgfTNTASYLRQQLHQCD.RNNPIDACSPVSDNMTAQLQDAEGELHEEIEKLLtSGTSVDRPTmdRLFQTVVGRLESSW
 1264- 1319 (73.20/33.06)	.....................................LFPSQ.KN......PPASDPLSLESIQLAGSLLSVVEAIL.RGRPAARTS..QLTSGMVEKLAELW
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     272.86|      67|     238|     363|     431|       2
---------------------------------------------------------------------------
  286-  348 (66.88/44.14)	PPPRVTLTDTKremW.....LRDLanpS.ISLRRLSRTIP.............HGIRgkvLLDH.....CLNKNVPTEravWLVKCV
  363-  431 (116.40/90.31)	PGPFVLGGEAK...W.....LRDW...T.VFVEQFMEGVSTAFGDNDWKVKVQYAIR...LATHLyaEQLLDRDHYMD...WLVSGL
  440-  507 (89.59/62.09)	P.MWILITQIY...WkdllrLRKY...GrRLVNALLSHLHTIHNDPDRDILVQLSAR...LATLL..TPLL..SAHPD...NFVS..
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     119.77|      36|     552|     543|     614|       3
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  564-  603 (61.51/97.92)	TTYTSLY...SPDLAAQcwavSEDKNMIVRTLLEWCTSPHRPG
  705-  743 (58.25/21.44)	TTRSSLLrraSYDVKEE....AEDINMAIKCIDHALGLPLQPG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.63|      13|      15|       1|      14|       4
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    1-   14 (21.89/14.87)	MGVQpRPPQQRTVS
   18-   30 (24.74/11.67)	LSVQ.RPTHQRTLS
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     120.46|      36|     552|     795|     849|       5
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  658-  698 (59.26/30.31)	DFQLQGYIFWLIARGglrrpADTEADGSCATRLLVDLPLHA
  810-  845 (61.21/39.29)	DFSALAEIIKLVVRA.....SNPEILASCADTINVHLPIFA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     127.73|      38|     823|     606|     648|       7
---------------------------------------------------------------------------
  606-  648 (59.55/50.02)	KVYITAGLLRAWVAvgvdvTTAVLEYLSSNPPTETNSKRVFHR
 1435- 1472 (68.18/45.21)	RVLLTGGTMQNPAS.....SDARLQYLFSHMPPQTEQFVLAHR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     106.40|      33|    1013|     157|     192|       8
---------------------------------------------------------------------------
  157-  192 (56.85/50.30)	DGRPkaWHFET..PAAAPRYAPFNKQR......NDATNKPGfGG
 1173- 1213 (49.55/32.17)	DESP..LTFETvlELANEFTLPFCQLKlsiglsADSATSPG.GG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     229.42|      75|     321|    1026|    1108|       9
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 1026- 1108 (113.52/88.83)	IVLTTTSIDAG......RIALNPSGPTNSTTTYMQE....VLHLTTMPLTAkTALTPEETYRfYIQQQVVprqnhkDMVLLVRNALIEYSRLQ
 1348- 1432 (115.89/69.42)	ITLHTTANEPMsapaqvQVTNNMKPPVNAAAFEIRArilvILSGLTLELDA.LALQDPHTGR.TLSQQVF......DLALLLIDTLPEDSRLQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      99.04|      31|     513|     252|     284|      10
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  252-  284 (44.63/41.22)	LKHKSGLNLLsSIFVGVLNQRKlNGQILSPSTF
  768-  798 (54.41/39.31)	LQTEVGARLL.QIFTTEIVMTK.NGPQVSPAMF
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP00609 with Med12 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MGVQPRPPQQRTVSSSGLSVQRPTHQRTLSAQYLPQSPVRKETPIDLTGDANGAAVAQNRYGSLPRRGGSRLKLELSNDAMLAQHPITDSPKTLTPSRLMPKNDPSNLAEMGSPSSAKGQPIDADNPPMPMPKRRPRFVARPAAKDSPAPTVAIKKDGRPKAWHFETPAAAPRYAPFNKQRNDATNKPGFGGSGTGT
1
197










Molecular Recognition Features






MoRF SequenceStartStop




1) FVYRKW
2) RRPRFVARPAAKDSPAPTVAIKKDGRPKAWH
1502
134
1507
164