<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP00605

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMENGGLNGAHLSHDRNMKANGINGEKMDGQPSPNKGKAPAEIPGSDSIANGVPDSLGKQQTQMSTGLTLQQKPRMNDLPEEIVHITQGYIPLSMIVSRLAQRTHEDLQKTILDMAAIKWAPPAVNGNTPHGTDASDDMSEGNKRRKMLMLKFAQDAHSKWVKALVITDWSRNAEAVSKLIDIKAHIDSKRMLFDFCQDLLIDLKRSLISARLPNPDLKTALQVLTTGEASWIPEPGYIPPLPLTTEEQLKWIDDLNTMLSLRLNLDDYDKIPHQFKNYTIQSGRVTFKVKGEFEVDLTIADEDFTKQFWFIDFRFAFSPSSSKLSDALVSYLELKVNEILGQDGLEGCYRFLHEFVLTHKINELRRQALELSRSTWTGTLMVEPLNRALALQYWTSRYGPNGPKSWVMVAVNSAKRTNGQTDPKHSSRLVARWYRDNKEVRDVFLPFDVDNLCAEDLLKTAVARHVEHILSSIHTKLLSYPRFVKRESSMTLKISRTEPMESSLSMQLGSRDNVTLIIQPVTGFAAIRPHTKYSLNGENRLNYGGKDPAEDGVTCLENIRWGYIIEEFNRRGRTVGWRGCKSPIGSEDIKQIIRTREAFQTVFLQRQSLGQEWFVMVSLSLNGDEWWLLEVDRNTPARPVKFQTKLELTRGQPDLDDAFWSNLTLFVTGIITQVTDLEDLHQRQVKYLRRESTNYALPQQVRLPSLVLRLSQILRSSETSSHKTSQETPNGWDNHNSSWAQDQIEVKFKGLQPQPSAIQAPDGNAQSGAEALENARLNTVVDAIVRVKDKAKFSLLKGRIDRDICFNPRKGEFIFRIRQLVGQPILGTLTTHVKSIDRLVGFLEAMGKARGDVKCERVSLREVIFTYSDIKMPSESDTTQKPKRWRVSLDLAKSDIRMYLERGNPHLRVLDLLTTLVNTQNGLKAILVYMPLLLPILRTLDNIESKWEPLTTTNQGRLEIFARTIDWIALRYTLPGPNGQQRVLGLEMRSKVRRSDVWWNFSRSTSGPGGPPPPEEEFNRVLRGIWESHGDGWRGLMTGAAALPGPSTMQLLTKLDDAVRAYAVTGDISEAPSTGGAQTQSSQTFSTNQSFGTHPTNVSQGSNRSSGGSKQAPLVLD
Length1117
PositionTail
OrganismColletotrichum sublineola (Sorghum anthracnose fungus)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Glomerellales> Glomerellaceae> Colletotrichum> Colletotrichum graminicola species complex.
Aromaticity0.07
Grand average of hydropathy-0.460
Instability index42.94
Isoelectric point8.95
Molecular weight125853.77
Publications
PubMed=24926053

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU365082
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP00605
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     131.97|      36|     146|     623|     659|       1
---------------------------------------------------------------------------
  624-  659 (65.62/48.82)	DEWWLLEVDRNTPARPVKFQTKLE.LTRGQPDLDDAF
  787-  806 (24.05/11.21)	................VKDKAKFS.LLKGRIDRDICF
  996- 1024 (42.30/23.34)	DVWWNFSRSTSGPGGPPPPEEEFNrVLRG........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     207.55|      68|     151|     514|     590|       2
---------------------------------------------------------------------------
  514-  590 (101.57/89.12)	VTLIIQPVTGFAAIRP.HTKYsLNGENrLNYGgkDPAEDGVTCLeNIRWGYIIeefnRRGRTV..........GWRGCKSPIGSEDIK
  667-  745 (105.97/64.78)	VTGIITQVTDLEDLHQrQVKY.LRRES.TNYA..LPQQVRLPSL.VLRLSQIL....RSSETSshktsqetpnGWDNHNSSWAQDQIE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      97.84|      31|     784|     149|     181|       4
---------------------------------------------------------------------------
  149-  181 (44.63/39.64)	MLKFAQDAHSKWvKALVITDWSRnAEAVSKLID
  936-  966 (53.21/36.58)	ILRTLDNIESKW.EPLTTTNQGR.LEIFARTID
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      82.07|      25|      67|     967|     993|       7
---------------------------------------------------------------------------
  967-  993 (42.24/25.81)	WIAL...RYTLPGPNGQQrvLGLEMRSKVR
 1033- 1060 (39.82/19.10)	WRGLmtgAAALPGPSTMQ..LLTKLDDAVR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      81.27|      25|     721|      26|      50|       8
---------------------------------------------------------------------------
   26-   50 (45.99/29.55)	KMDG.QPSPNKGKAP..AEIPGSDSIAN
  747-  774 (35.28/20.84)	KFKGlQPQPSAIQAPdgNAQSGAEALEN
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP00605 with Med14 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AVTGDISEAPSTGGAQTQSSQTFSTNQSFGTHPTNVSQGSNRSSGGSKQAPLVLD
2) MENGGLNGAHLSHDRNMKANGINGEKMDGQPSPNKGKAPAEIPGSDSIANGVPDSLGKQQTQMSTGLTLQQKPRMNDLPEEI
1063
1
1117
82










Molecular Recognition Features






MoRF SequenceStartStop




NANANA