<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP00597

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMDTSEYDTNTLLNNNISSIIYRVYEPSQEHAQTFPSAAADIETELRNRGHIVYYDATRRVLWYFHIPSKDAVLGDESHGILGNSVSIAGATLLTVDDGSFEPVSLFKGRALGQQPANTPTSSSSSNSALDLSLRNQQTGTSAPPTSFDPEPKGTGLIALPDAYEQFITAVLSTVSAVFCSRVSAIPLNHRTVLLPSKVMRDDQAERALDTESAVVGTFRIYLTTTGTLVMSLALSCCEGLLSVNEPCSPSQLVLGSQILAAPFGVLANYQGFVGGGLSYPELGLGQTPDAQLWRGADARSSQWRDTCINILQSRGLSPTLLQSCPWIALQILRRKSGEHKIEGKTTPFPSTLATISWPAVLCFRKKSVMLARNNGLGDPVLLAQDETSDFLNEARTWFQLGTERDEKISRRKKEREIAASKEAAAVAPAQQANGHSPLGLRRASNAAAAGTMYPTPPDGVQNPLGITPSMDGTTSSPGAPGTTMAVVDIDTTMADTGTHDTPAMNTNQHSEAYGDGWHSSDSKRDRADSFLAGDNDNLFGDMGPDMFGDTDITDADFSFFDEEGGDDLDLSVLPDLGMPDAPPAPPAIPVPVPEPAKLMLPVGEEAKPALSPPIFAKPELKHARSTLLDEGKQKSNGERAAGVKRESSPFDPDTVYKRVRASLADLRSTPQRTPARKGSVFDSVDFDPVLPLVNKKYEQGGRFDCLPRFQGQPQDASKQIVSQGPPMTDYLRRHGKQRKTLRQPERTNAVIRTITGSLENSSLVASPGKGDDLASDADDISLVSDQDDSSASEDEPASPFKSSIRRLNLDDDVASHVTSLKDIESVDDSDPALALDLPKLAKAEASELLIPKYFEDAESLPIYLSLPDEDTITIAQIVTEQAVTGNLRIRDALANTLNTAIVSDTRRQLSSLGRTALQALREVIPPCLGEFNTCNFKGLVEVPDVPLIGPPSRLHPRPVNPRDNAEPPKPNNIFQIPAPHMELRRAEARLSVLPASVQFWESLGLGPAQGTKDVNVVCVFPHWDGMSDVATAFLDRMRNVYELLKLGSFERLPSSPKVADGLLPFEADKVATSPGTVSPHIVAALGERMEALNQSLLSANAKGKNFVIYFVYPPDHPGSIVEACTAFQQLFEMHKRSLTDKRQTPANELVLQLVPLDFLTSSKGMVEPTPSDAIKLAIETYDRCTLFGGPMPSPAIILEQSFPRGIDFKLSATSSSSLMHENTCIHIAYAQSIDERWVTAAWTDNRGCQQMTASYNLGRKGKPLSTSLNDVCHEIWETTHDLISKWKVHWRVVISKCGFMDAQEIGFWQGLAQTESVATVSLTLISVDTNPSMQLVPPAIKVSATAPSAFYTTPVSTPQPSIVSPEQSGTPVTPMKENNPVNAATPGGTLGDGNAEPTEGDAILLDVTDQSWGAVLAHRLNNSCSLGELNPALISGYLVKRGGTKLEDPPVIMEVNIVHADNNPRMYEPLMREMLTYFRGLGTLARARGVTDRGTDVRPWHIAAAEKGVRALYLLM
Length1516
PositionKinase
OrganismColletotrichum sublineola (Sorghum anthracnose fungus)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Glomerellales> Glomerellaceae> Colletotrichum> Colletotrichum graminicola species complex.
Aromaticity0.06
Grand average of hydropathy-0.291
Instability index48.31
Isoelectric point5.12
Molecular weight164085.15
Publications
PubMed=24926053

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
ECO:0000256	RuleBase:RU364134
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP00597
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     138.74|      43|     171|    1151|    1201|       1
---------------------------------------------------------------------------
  437-  487 (59.13/22.99)	PLGLRRASNaaaaGTMYPTPPDGVQnpLGItPSMDGTTSSpGAPGTTMAVV
 1155- 1197 (79.61/51.59)	PLDFLTSSK....GMVEPTPSDAIK..LAI.ETYDRCTLF.GGPMPSPAII
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     442.37|     141|     171|      77|     222|       2
---------------------------------------------------------------------------
   77-  222 (218.13/121.73)	SHGILGNSVSIAGATLLTVDDGsFEPVSL.FKGRALGQQP.ANTPTSSSSSNSALDLSLRN..QQTGTSapPTSFDPEPKGTGLIALPDAYEQFI....TAVLSTVSAVfcSRVSAIPLNHRTVLLPSKVMRDDQAERALDTESAVVGTFRIYL
  250-  398 (224.24/111.10)	SQLVLGSQILAAPFGVLANYQG.FVGGGLsYPELGLGQTPdAQLWRGADARSSQWRDTCINilQSRGLS..PTLLQSCPWIALQILRRKSGEHKIegktTPFPSTLATI..SWPAVLCFRKKSVMLARNNGLGDPVLLAQDETSDFLNEARTWF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      89.34|      30|      33|     765|     797|       3
---------------------------------------------------------------------------
  766-  796 (47.68/31.46)	SPGKGD..DLASDaDDIS..LVSDQDDSSASEDEP
  798-  831 (41.66/22.19)	SPFKSSirRLNLD.DDVAshVTSLKDIESVDDSDP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     100.26|      31|      32|     514|     545|       6
---------------------------------------------------------------------------
  514-  545 (52.77/39.69)	GDGwHSSDSKRDRADSFLAGDND.NLFGDMG.PD
  548-  580 (47.49/29.01)	GDT.DITDADFSFFDEEGGDDLDlSVLPDLGmPD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     253.76|      83|     247|     653|     763|       7
---------------------------------------------------------------------------
  671-  759 (135.70/101.92)	QRTPARKGSVFDSVDFDPVLPLVNKKYEQGGRFD.C.LPRFQGQPQDASKQIVsqGPPMtdylRRHGK..QRKTLRQPERTNAVIRTITGSLE
  929-  982 (70.14/27.71)	..............................GEFNtC...NFKGLVEVPDVPLI..GPPS....RLHPRpvNPRDNAEPPKPNNIFQIPAPHME
  984- 1025 (47.92/12.41)	RRAEARLSVLPASVQFWESLGLGPAQGTKDVNVV.CvFPHWDG..................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     129.06|      34|     788|     585|     618|      10
---------------------------------------------------------------------------
  581-  615 (59.38/30.75)	APPaPPAIPVPVPEPAKLM.LPVGEEAKPALSPPIF
 1337- 1368 (43.95/20.67)	....PPAIKVSATAPSAFYtTPVSTPQPSIVSPEQS
 1369- 1386 (25.73/ 8.76)	GTP......V...TPMKEN.NPV.NAATP.......
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP00597 with Med13 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) ASDADDISLVSDQDDSSASEDEPASPFKSSIR
2) GRFDCLPRFQGQPQDASKQIVSQGPPMTDYLRRHGKQRKTLRQPERTNAVIRT
3) GTERDEKISRRKKEREIAASKEAAAVAPAQQANGHSPLGLRRASNAAAAGTMYPTPPDGVQNPLGITPSMDGTTSSPGAPGTTMAVVDIDTTMADTGTHDTPAMNTNQHSEAYGDGWHSSDSKRDRADSFLAGDNDNLFGDMGPDMF
4) LDLSVLPDLGMPDAPPAPPAIPVPVPEPAKLMLPVGEE
5) LGQQPANTPTSSSSSNSALDLSLRNQQTGTSAPPTSFDPEP
6) LKHARSTLLDEGKQKSNGERAAGVKRESSPFDPDTVYKRVRASLADLRSTPQRTPARKGSVF
7) PVSTPQPSIVSPEQSGTPVTPMKENNPVNAATPGGTLGDGNAEPTEGDAI
774
701
401
568
111
620
1354
805
753
547
605
151
681
1403










Molecular Recognition Features






MoRF SequenceStartStop




1) TDITDADFSFFDEE
2) VYKRVR
550
655
563
660