<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP00593

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMDQRKAPPSATRSNSDSSGRANDAMVPVENDNPMRAPSAASMLLQASPAAKGASHRQQALKASGNHAAPVIANGHHAAIPQGQAGPSKVALSSQSPTSSSNSGIAGLPVRSPATASTTSAMAPSPALHQLQYQLQQQQQGSRKYVPPLSARAMEKRPMLDLQIPLERLEAEVQHEPEGLIPLTDVVTRLANYGYESLQNLGETMSSLSGEQRRSKIYNTALEARRQFIKLLVLSIWSSKAPGIIRTRDLIGLVNEQFNQSNDVVQELTAIRRSLPNSRARQYDLETAADVLNTGTYSRAPHSVGGFYEVQREYTDAEAKQIVEELNEAIQIRLSCGENLPDELCDYSIVDGRAILRASNLFEASITLSGKDPQDRWYLLSIEFDISVVGTGSQHFPRQPSKLQRTRIQTQADAVLTPRGLEPEGGLVAETEAKPPDRDMAGCSSDPEALTRLFSFLRTCALGYQLEALHYQARQLVSQEWGANLAVEWHPGRSLQLRYWNLLVPPAQNRSQAVARKPQDLLTSGVIIIEVPSEDTGSSDDEGEGLQRRSNARLTVKRPASNVCGADDPQVNCKELDLGQIMRTVTAEQAQHSLLRIVKAALPADEPTALLDIARRRVSVELALPAGRSLEVSLSCVSGRLDLHLADNAEGRQPTALAKALGSFAGLLADSTARVNADPRRFADVWRAIRLEVMMQDTEQRLAFAGLQSTRKLPFADGEVLKLDGMRRFAFIYAPVDRWPSYYLIVAISAEDIRVGLICADFSPSGGALFTIHSIEWIDRERIREAAGEAAHAFPLMLTANEIRQAHNYCIAIICYFRVEQQLNNWQVPFARVRSWPPQLQEERQLATREVHPSKIDALIPCLSLNSQELLGEFSEMVKPNVFLCIDDWWERTNVHARFAICWKANLGISAESTNTPEGLRVSYDPSTRIMRISASDIDRCVDAFKLFALRISRVAVLAKAVARVQKRKIIPKLRLNELSLSQISFEYCGGFTATVRWVMHLGGQWQYRLSLLARDAAENPHKLIERHLEAYLNNTTTSSSVHWLRFLRLLRDTFPMLDSLQALQKSGEGTSQQLTIEALSVSQVLVLFRKNCALDIRLISGSRLLLSDGYRCGLHSGQYPTLGFNPRAPRVQLPEFCKVVQSTYEQSKLELEPLVAKLAEESASPEAAIGKGIDSHAAARKGTVQPLVTNLRHSLLCRADDEVARPIVTMLVTRILSGHTM
Length1221
PositionTail
OrganismTilletiaria anomala (strain ATCC 24038 / CBS 436.72 / UBC 951)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Ustilaginomycotina> Exobasidiomycetes> Georgefischeriales> Tilletiariaceae> Tilletiaria.
Aromaticity0.06
Grand average of hydropathy-0.263
Instability index47.00
Isoelectric point8.00
Molecular weight134991.09
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP00593
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.86|      13|      23|     361|     373|       1
---------------------------------------------------------------------------
  361-  373 (22.52/13.55)	FEASITLSGKD..PQ
  383-  397 (18.34/ 9.69)	FDISVVGTGSQhfPR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     396.79|     133|     354|     567|     712|       2
---------------------------------------------------------------------------
  567-  712 (189.73/124.93)	DPQVNCKELDLGQIMRTVTAeqAQHSLLRIVKAALPAdepTALLDIARRRVSVELALPAGRSLEVSLSCVSG.................RLDLhLADNAEGrQPTAL.AKALGSFaglLADSTARVNADPRRFadvWRAIRLEVMMQDTEQRLAFAGLQSTRKL
  924- 1074 (207.06/105.35)	DPSTRIMRISASDIDRCVDA..FKLFALRISRVAVLA...KAVARVQKRKIIPKLRLNELSLSQISFEYCGGftatvrwvmhlggqwqyRLSL.LARDAAE.NPHKLiERHLEAY...LNNTTTSSSVHWLRF...LRLLRDTFPMLDSLQALQKSGEGTSQQL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.33|      15|      16|      94|     108|       3
---------------------------------------------------------------------------
   94-  108 (27.66/15.46)	QSP.TSSSNSGIAGLP
  110-  125 (23.67/12.20)	RSPaTASTTSAMAPSP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.09|      14|      17|     478|     493|       4
---------------------------------------------------------------------------
  478-  493 (24.36/21.15)	QEWgaNLAVEWHPGRS
  497-  510 (27.74/16.61)	RYW..NLLVPPAQNRS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP00593 with Med14 domain of Kingdom Fungi
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