<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP00554

Description "Cyclin-dependent kinase E,1 isoform 2"
SequenceMGDGNNTSGRGIAANSTTSSSNSEKPEWLQQYNLLGKIGEGTYGLVFLARIKSQTNRGKCIAIKKFKQSKDGDGVSPTAIREIMLLREITHENVVKLVNVHINHADMSLYLAFDYAEYDLYEIIRHHRDKVNHAINQYTVKSLLWQLLNGLNYLHSNWIIHRDLKPSNILVMGDGDEQGVVKIADFGLARIYQAPLKPLSENGVVVTIWYRAPELLLGAKHYTSAVDMWAVGCIFAELLTLKPLFQGAEAKSTPNPFQLDQLDKIFKILGHPTLEKWPTLGNLPHWQSDLQHIQGHKYDNAGLHSVVHLSPRSPAFDLLSKMLEYDPRNRITAAQALEHEYFRIDPLPGRNALVPSQPGEKIVNYPTRPVDQNTDFEGTTSIQQSQPVSSGNAVAGNMGGAHAGRNGSVNRPMPAPMQRMPQGMMAYNFPAQAGVAGGMNPGGIPMPRNIATQAHQQQQLRRKDPGMNMPGYPPQQKSRRIHDLQDCELPQVRNVSSKYQCWITWLFLFDEYYQSCNYLCVAIFCLRTQGSGAGVESVDASEGSKTQCYGSQAL
Length554
PositionKinase
OrganismTheobroma cacao (Cacao) (Cocoa)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> malvids> Malvales> Malvaceae> Byttnerioideae> Theobroma.
Aromaticity0.08
Grand average of hydropathy-0.412
Instability index41.76
Isoelectric point8.45
Molecular weight61703.48
Publications
PubMed=23731509

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IBA:GO_Central
nucleus	GO:0005634	IBA:GO_Central

GO - Biological Function
ATP binding	GO:0005524	IEA:UniProtKB-UniRule
cyclin-dependent protein serine/threonine kinase activity	GO:0004693	IBA:GO_Central
RNA polymerase II CTD heptapeptide repeat kinase activity	GO:0008353	IBA:GO_Central

GO - Biological Process
protein phosphorylation	GO:0006468	IBA:GO_Central









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP00554
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     147.32|      40|      42|     391|     432|       1
---------------------------------------------------------------------------
  391-  432 (73.55/48.14)	GnaVAGNM..GGAHAGRNGSVNRPMPAPMQRMPQGMMAYNFPAQ
  434-  475 (73.77/42.71)	G..VAGGMnpGGIPMPRNIATQAHQQQQLRRKDPGMNMPGYPPQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     139.76|      41|     169|     119|     159|       2
---------------------------------------------------------------------------
  119-  159 (74.79/54.24)	DLYEIIRHHRDKVN.HAINQYTVKSLLWQLLNG.LNYLHSNWI
  289-  331 (64.97/46.12)	DLQHIQGHKYDNAGlHSVVHLSPRSPAFDLLSKmLEYDPRNRI
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP00554 with CDK8 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) ALVPSQPGEKIVNYPTRPVDQNTDFEGTTSIQQSQPVSSGNAVAGNMGGAHAGRNGSVNRPMPAPMQRMPQGM
2) GGMNPGGIPMPRNIATQAHQQQQLRRKDPGMNMPGYPPQQKSRRIHDLQDC
352
437
424
487










Molecular Recognition Features






MoRF SequenceStartStop




NANANA