<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP00519

Description Heat shock protein 70 (Hsp 70) family protein
SequenceMAIKNKAFWVLFLFISEFFLGIAVAADETKVGTVIGIDLGTTYSCVGVYKNGHVEIIANDQGNRITPSWVAFTDTERLIGEAAKNQAALNAERTIFDVKRLIGRKFDDPEVQRDIKFLPYKVVNKDGKPYIQIKVKGETKVFSPEEISAMVLTKMKETAEAYLGKKIKDAVITVPAYFNDAQRQATKDAGTIAGLNVARIINEPTAAAIAYGLDKKGGEKNILVYDLGGGTFDVSILTIDNGVFEVLATSGDTHLGGEDFDHRVMDYFIKLIKKKYNKDISKDNKALGKLRRECERAKRALSSQHQVRVEIESLFDGVDFSEPLTRARFEELNMDLFKKTLGPVKRALEDANLKKSDISEIVLVGGSTRIPKVQQLLKDLFDGKEPSKGINPDEAVAYGAAVQGGILSGEGGEETKDILLLDVAPLSLGIETVGGVMTKLIPRNTVIPTKKSQVFTTYQDQQTTVSIKVYEGERSLTKDCRELGRFDLTGIPPAPRGVPQIEVTFEVDANGILHVTAEDKAAKKSQSITITNDKGRLSQEEIEKMVKEAEEFAEEDRKVREKIDSRNKLETYIYNMRSTIDDKDKLADKLGSDDKERIESTLKEALEWLDDNQNGGKEDFDEKLKEVEAVCNPIIKQVYEKSSGSSAGSEEEDEPTDEL
Length659
PositionUnknown
OrganismTheobroma cacao (Cacao) (Cocoa)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> malvids> Malvales> Malvaceae> Byttnerioideae> Theobroma.
Aromaticity0.07
Grand average of hydropathy-0.428
Instability index32.65
Isoelectric point5.16
Molecular weight73030.03
Publications
PubMed=23731509

Function

Annotated function 
GO - Cellular Component
cytoplasm	GO:0005737	IBA:GO_Central
endoplasmic reticulum chaperone complex	GO:0034663	IBA:GO_Central
endoplasmic reticulum lumen	GO:0005788	IBA:GO_Central
membrane	GO:0016020	IBA:GO_Central
nucleus	GO:0005634	IBA:GO_Central

GO - Biological Function
ATP binding	GO:0005524	IBA:GO_Central
ATPase activity	GO:0016887	IBA:GO_Central
heat shock protein binding	GO:0031072	IBA:GO_Central
misfolded protein binding	GO:0051787	IBA:GO_Central
protein folding chaperone	GO:0044183	IBA:GO_Central
unfolded protein binding	GO:0051082	IBA:GO_Central

GO - Biological Process
cellular response to unfolded protein	GO:0034620	IBA:GO_Central
chaperone cofactor-dependent protein refolding	GO:0051085	IBA:GO_Central
endoplasmic reticulum unfolded protein response	GO:0030968	IBA:GO_Central
protein refolding	GO:0042026	IBA:GO_Central
ubiquitin-dependent ERAD pathway	GO:0030433	IBA:GO_Central









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP00519
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      76.41|      25|      26|     558|     582|       1
---------------------------------------------------------------------------
  558-  582 (41.30/31.81)	KVREKI..DSRNKLETYIYNMRSTIDD
  585-  611 (35.11/25.85)	KLADKLgsDDKERIESTLKEALEWLDD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.06|      16|      16|     181|     196|       2
---------------------------------------------------------------------------
  181-  196 (27.61/17.61)	AQRQATKDAGTIA.GLN
  198-  214 (20.45/11.25)	ARIINEPTAAAIAyGLD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      38.44|      13|      27|     103|     119|       5
---------------------------------------------------------------------------
  103-  119 (19.39/22.00)	GRkfddPEVQRDIK.....FLP
  127-  144 (19.05/ 9.66)	GK....PYIQIKVKgetkvFSP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP00519 with Med37 domain of Kingdom Viridiplantae
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