<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP00518

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMAELGQQTVEFSSLVSRAAEESFLSLQELVEKSKSSDQSDTEKKINLLKYIVKTQQRMLRLNVLAKWCQQVPLIQYCQQLVSTLSSHDTCFTQAADSLFFMHEGLQQARAPVYDVPSAVEVLLTGSYERLPKSIEAVGMQSSLSEDQQKPALRKLDTLVRSKLLEVSLPKEISEVKVSNGTALLRVDGEFKVLVTLGYRGHLSMWRILHLELLVGEGSGLVKLEEMRRHALGDDLERRMSAAENPFNTLYSVLHELCVALVMDTVIRQVQALRQGRWKDAIRFELISDGGSGGSTQVNQDNESDSAGLRTPGLKLVYWLDFDKNSGASDSGACPYIKIEPGPDLQIKCQHSTFVIDPLTGKEAAFSLDQSCIDVEKLLLRAISCNRYTRLLEIQKELVKNVQICRATSDVVLHSQADEPDSEHKKKDAKLDNKEHEGQEVLRVRAYGSSYFTLGINIRNGRFLLQSSQNILSPSALLDCEEALNQGTMTAADVFTSLRSKSILHLFASIGRFLGLEVYEHGFAAVKVPKNLVNGSAVLVMGFPDCESSYFLLMELDKDFKPLFKLLETQPDPSGKGPSFNDLNNVLRIKKIDISQMQMLEDETNLSILDWGKLLSYLPNIGGPNQTSEHGLLSEFNLDSSMQISGGPSLSFSSIVDEVFETEKGTSATPFPSQNFSSFSSSPASHLGSVPMNIHGVKAGTPSPKWEVGLQVSQLNNVAKVSSPATHYGSSLYPSSGLKGSLQSSSFGSLSSGTGRGTSAKKLSTSKSDQDLASLRSNHSVELGALDEDQLRLLNDTSKDALSASRSSRLLSPPRPTVPRVSAQIAKPNGPRSSSSANLTASVRFAGSSPLASPPVSQAAETPICHGTSHDVAKHDKNPRKRTVSDMLSLIPSLQGIEADAGIRKRKKTSDVAYTQQPSSQVLISTEMINKTEVYSYGNLIAEANKGNAPSCIYVSALLHVVRHSSLCIKHARLTSQMEELDIPYVEEVGLRNASSNIWFRLPSARGDSWRHICLRLGRPGRMSWDVKINDQHFRDLWELQKGGNNTPWGSGVRIANTSDVDSHIRYDPDGVVLSYQSVEADSIKKLVADIRRLSNARMFALGMRKLLGVRADEKPDEGSANSDVKASVGGKGAVDVADKLSEQMRRSFKIEAVGLLSLWFCFGSGVLARFVVEWESGKEGCTMHVSPDQLWPHTKFLEDFIDGAEVASLLDCIRLTAGPLHALAAATRPARASPAPGVPGASAAVSSMPKQSGYIPSQGLLPSSSTTNVNQAASGPAGNPVASGSASSLGNHGLHGAGMLVAPPGRGGPGIVPSSLLPIDVSVVLRGPYWIRIIYRKRFAVDMRCFAGDQVWLQPATPPATPPAGGSSVGGSLPCPQFRPFIMEHVAQELNGLDSGFTSGQQTVGLANSNNPNLNSGPQLSANGNRVNLPTSAAMSRAANQVAGLNRVGNALPGSPNLAVVSSGLPIRRSPGSGVPAHVRGELNTAIIGLGDDGGYGGGWVPVVALKKVLRGILKYLGVLWLFAQLPDLLKEILGSILKENEGTLLNLDLEQPALRFFVGGYVFAVSVHRVQLLLQVLSVKRFNQQQQQQQQQNNANAQEELTQSEICEICDYFSRRVASEPYDASRVASFITLLTLPISVLREFLKLIAWKKGLAQTQGGDIAPAQKPRIELCLENHTGVNVDDSSESSSMTKSNIHYDRPHNSVDFALTVVLDPAHIPHINAAGGAAWLPYCISVRLRYSFGENPSVSFLGMEGSHGGRACWLRLDDWEKCKQRVARTVEVSGCTAGDAAQGRLRAVADHVQRALICAFKD
Length1813
PositionTail
OrganismTheobroma cacao (Cacao) (Cocoa)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> malvids> Malvales> Malvaceae> Byttnerioideae> Theobroma.
Aromaticity0.06
Grand average of hydropathy-0.208
Instability index45.41
Isoelectric point7.55
Molecular weight196485.88
Publications
PubMed=23731509

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU365082
GO - Cellular Component
core mediator complex	GO:0070847	IBA:GO_Central
mediator complex	GO:0016592	IBA:GO_Central
GO - Biological Function
transcription coregulator activity	GO:0003712	IBA:GO_Central
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP00518
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.32|      20|      21|     634|     653|       1
---------------------------------------------------------------------------
  634-  653 (35.48/18.28)	E.FNLDSSMQISGGPSLSFSS
  657-  677 (31.84/15.67)	EvFETEKGTSATPFPSQNFSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      88.60|      20|      21|    1263|    1282|       2
---------------------------------------------------------------------------
 1241- 1262 (24.81/11.94)	ASAAVSSMPKQSGyiPSQGLLP
 1263- 1282 (32.92/18.94)	SSSTTNVNQAASG..PAGNPVA
 1283- 1302 (30.87/17.17)	SGSASSLGNHGLH..GAGMLVA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.83|      19|      21|    1414|    1432|       3
---------------------------------------------------------------------------
 1406- 1428 (25.95/12.03)	LANSnnpnLNSGPQLSANGNRVN
 1429- 1449 (24.88/11.20)	LPTS..aaMSRAANQVAGLNRVG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.76|      11|      19|     698|     708|       4
---------------------------------------------------------------------------
  698-  708 (21.85/12.76)	AGTPSPKWEVG
  718-  728 (19.91/10.90)	AKVSSPATHYG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     100.44|      32|     764|     967|    1023|       5
---------------------------------------------------------------------------
  374-  407 (46.22/19.56)	VEKLLLRAISCNRYTRLLEIQKELVKnvQIC.......RAT
  985- 1023 (54.23/78.77)	VEEVGLRNASSNIWFRLPSARGDSWR..HIClrlgrpgRMS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     135.16|      34|      37|     742|     775|       6
---------------------------------------------------------------------------
  742-  775 (53.55/25.31)	QSSSFGSLSSGTG.R...GTSAKKLSTS...KSDQDLASLR
  778-  814 (48.53/22.28)	HSVELGALDEDQL.RllnDTSKDALSAS...RSSRLLSPPR
  818-  852 (33.08/12.97)	PRVS.AQIAKPNGpR...SSSSANLTASvrfAGSSPLAS..
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      33.50|      10|      21|    1506|    1515|       7
---------------------------------------------------------------------------
 1506- 1515 (16.81/11.03)	LKKVLRGILK
 1530- 1539 (16.69/10.88)	LKEILGSILK
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP00518 with Med14 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) LSASRSSRLLSPPRPTVPRVSAQIAKPNGPRSSSSANLTASVRFAGSSPLASPPVSQAAETPICHGTSHDVAKHDKNPRKRTVSDM
2) SSSFGSLSSGTGRGTSAKKLSTSKSDQDLASLRSNHSV
801
743
886
780










Molecular Recognition Features






MoRF SequenceStartStop




NANANA