<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP00497

Description Mediator of RNA polymerase II transcription subunit 12 isoform 2
SequenceMQRYHAASCTSAVNNSGIGGASARDTARADSSSLPPNFSLNSRRQTQLSPYKLKCDKEPLNSRLGPPDFHPQSQNCPEETLTRENVQQGYKETIDGLEDSKEISLTQVQAFTKPVVLKCRDAIRKCLRAINESRAQKRKAGQVYGVPLSGALLSKPGVFPEQRPCNEDFRKKWIEGLSQQHKRLRSLADQVPHGYRKKTLIEVLIRNNVPLLRATWFIKVTYLNQVHPGSAISSGAPDKAQLSRTELWTKDVIDYLQTLLDEFFPKSNSHSTQHSRDRLPQMLYAGSLQHRIDSASTILDGGEPSLHFKWWYVVRLLQWHHAEGLVLPSLIIDWLLNQLQEKELFEILQLLLPIIFGVLETIILCQTYVRNLVGIAIRFIREPSPGGSDLVDNSRRAYTISALVEMLRYLIQAVPDTFVALDCFPLPTCVVSHALNDGGFLSKSSDDAGKIKHNSADAYVLRGKGFDSQYQSLSFDHVVSTIQKRADNLAKGTSAGYPSQSVAKAVQTLDKALLQGDLMEAYKHIFENLCDGAVREGWVAEVSPCLRSSLKWIQTVNLSLICSVFFLCEWATCDFRDFRTAPPRDLKFTGRKDFSQMYLAIQLLKLKIRELQNPEHKNGRASGVNSTAKNISQQNNYSRRNLSGNLFEVKSKVRVVDGRNSNSSDIFDSPGPLHDIIVCWIDQHEGHKGEGGKRLQLFVLELIRSGIFYPQAYVRQLIVSGIIDTNGPVSDFDRRKRHHRILKQLPGQFMCDVLEEARIAVGSELLEAVNVYSNERRLVLHGLLSDQYSNANNAHVSAKKQKYHSTSGRNGASQASGDQRKTVQSSKAFRREVDLEELKASISVLLQFPSLSSASVDSGVDESQGSVKRPIGSTCNKMDLFEVTPGCEDCRRVKRQKLSEEKSSYLQVPSPIPSDDEDTWWVRKGPKNLEPFKVDPPLKSTKQVSRGRQKTVRKTQSLAQLAAARIEGSQGASTSHVCDNKISCPHHRTEVETLKPVDGIRITHSGDIISIGKGLKQLRFVEKRIVTVWLISVVRQLVEESEKSVAKVGQYGRPFVVADEKSPLRWKLGEDELSTILYLMDVSCDLPSAVKFLLWLLPKVISNPSPTIQSGRNILMVPRNVENHACEVGEAYLLSSLRRYENILIAADLIPEALAATMHRAAAVMASNGRITGSGTLVFARYLLKRYGNIASVIEWEKNFKATCDNRLLSELESGQAHDGEFGLPLGVPAGIEDPDDYYRQKLSGARLSRLGLSMRDMVQRHVDDVLHYFLGKERKLFAANAPKGPAIEKGDDGYQVAQQIAIGLLDCIRQTGGAAQEGDPVLVSSAISAIVTNVGPALAKIPDFTGGSNYSNYQPPMNSLNFAKRILRIHLICLSLLKEALGERQSRAFELALGIEASSALAVAFAPAKSSRGQFFLASDAPDTNANISGDNLNGSAKVTLGRTTKMVAAVSALVIGTVIHGVISLDRLVSVLRLREGLDVVQFVRSTKTSSNGNARSVGAFKVDNSVEVCVHWFRLFVGNCRTVCDGLVLELLGEQSVVALSRMQRLLPISLVFPPAYAIFAFVIWKPFILNSNIASREDIHQLYQSLTMAIGDAIKHIPFRDVCMRDSRAFYDILAADTTDAEFAGLPELNGKSMAFVPLRARLFLNAIIDCKMPNSAFTQDDGNRVSGHSEYKALRAESESNLLDKLVRALDTLQPAKFHWQWVELRLLLNEQALIDKTKNQEMSLVDAIRSSSPSSERASPSENEKVLIEIIFTRLLVRPDAAPLFSELVHLFGMSLEDSVLMQAKWFLGGQDVLLGRKTVRQRLINFAEINSRSMKTQFWKPWGWSYSGVDPVTNRGEKKKYEVTSLEEGEVIEEGTESKRYLKGSSQVDVEGSSISLQHVTEKAFSELVLPCIDQSSDDSRNTFASDLIKQFNIIEQQINSVTRGVSKQTGTATSGIEGSTNKGNNRKGIRGSSPGLARRTTATASAESVPPSPAALRASMSLRLQFIVRLLPIICADGEPSTRNMRHMLASVILRLLGSRVVHEDVDLSFNLVQLKRDMELMSSVASSELSGDSLFDRLLLVLHGLLSSSQPSWLGSKPASKHTSEFTGFDREAVESLQNELDSMQLPEMIRWRIQAAMPILFPSFRNLISCHPPSVPIGALSLLQPSIFVPGCYVGNLNAPQRQVPLARNANNILGKSKSMPLLQEYDMEIDPWTLLEDGAGSGPSSNSTVVIGSSDHANLRASNVLM
Length2237
PositionKinase
OrganismTheobroma cacao (Cacao) (Cocoa)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> malvids> Malvales> Malvaceae> Byttnerioideae> Theobroma.
Aromaticity0.07
Grand average of hydropathy-0.232
Instability index47.95
Isoelectric point8.82
Molecular weight247756.17
Publications
PubMed=23731509

Function

Annotated function 
GO - Cellular Component
integral component of membrane	GO:0016021	IEA:UniProtKB-KW
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP00497
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     379.08|      97|     927|     704|     814|       1
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  715-  813 (150.59/125.12)	RQLIVSGIIDTNGpvSDFDRRKRHHRILKQLPGQFMCDVLEEARIAVGSELLEAVNVYSNERRLVLHGLLSDQYSNANNAHVSAKKQKYHSTSGRNGAS
 1794- 1857 (83.89/58.85)	..............................LGGQ...DVL.LGRKTVRQRLINFAEINSRSMKTQFWKPWGWSYSGVDPVTNRGEKKKYEVTSLEEGE.
 1867- 1961 (144.60/109.89)	RYLKGSSQVDVEG..SSISLQHVTEKAFSELVLPCIDQSSDDSRNTFASDLIKQFNIIEQQINSVTRG.VSKQTGTATSG.IEGSTNKGNNRKGIRGSS
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     314.05|     105|     225|    1321|    1435|       3
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 1321- 1435 (148.23/113.29)	PV.LVSSAISAIVTNVgpaLAKiPdFTGGSNYSN.......YQPPMNSLNFAKRILRIHLICL...SLLKEALGERQSRAfELAlGIEASSALAVAFAPAkssRGQFFLAS..DAPDTNANISGDNLN
 1551- 1668 (165.82/95.27)	PIsLVFPPAYAIFAFV...IWK.P.FILNSNIASredihqlYQSLTMAIGDAIKHIPFRDVCMrdsRAFYDILAADTTDA.EFA.GLPELNGKSMAFVPL...RARLFLNAiiDCKMPNSAFTQDDGN
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     477.38|     157|     170|     895|    1063|       4
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  895- 1063 (241.57/163.25)	RQKLSEEKSS...YL.QVPSPIPSDDEDTWWVRkgPKNL.EPfkvDPPLKSTK...QVSRGRQKTVRKTQSLAQLAA.ARIEGSQGAstSHVCDNKISCPHHRteVETLKPVDGiRITHSGDIISIGKGLKqlRFVEKRIVTVW....LISVVRQLVEESEKSVAKVGQYGRPF.VVADEKSP
 1065- 1235 (235.80/130.74)	RWKLGEDELStilYLmDVSCDLPSAVKFLLWLL..PKVIsNP...SPTIQSGRnilMVPRNVENHACEVGEAYLLSSlRRYENILIA..ADLIPEALAATMHR..AAAVMASNG.RITGSGTLVFARYLLK..RYGNIASVIEWeknfKATCDNRLLSELESGQAHDGEFGLPLgVPAGIEDP
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     226.37|      74|     301|     115|     195|       7
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  115-  195 (109.02/116.60)	VVLKCRdAIRKCL..RAINES...RAQKRKAGQVYGVPLSGALLSKPGvFPEQRPcNEDFRKKwiegLSQQHKRLRSLADQVPHGY
  419-  497 (117.35/93.34)	VALDCF.PLPTCVvsHALNDGgflSKSSDDAGKIKHNSADAYVLRGKG.FDSQYQ.SLSFDHV....VSTIQKRADNLAKGTSAGY
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     114.42|      34|    1393|     283|     317|       8
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  283-  317 (59.03/50.16)	LYAGSLQHRIDSASTILDGGEPSlHFKW.WYVVRLL
 1679- 1713 (55.39/41.40)	LRAESESNLLDKLVRALDTLQPA.KFHWqWVELRLL
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP00497 with Med12 domain of Kingdom Viridiplantae
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