<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP00493

Description DNA helicase (RECQl4A) isoform 2
SequenceMNDKLPKINWLSHVDAHDNFSCQKKFLSSNFLCSLETQKPCTEEEIRARLRVCQIQNSQKVQHPQVEKAWQILSSLPTSCRTYLRPGTTAPVKNSNDEISHNWRGRSTLTNSSDMKWSKHMHVSRNVNETDGKINEVGRCMASSFPSSNANAVEDGNHLQRHSEIKASMSNRSNSKVLGGSLWNHIVHASQLEQSAEVLADEIDDDDLLKDIDVDQIVSKHYQSTCTPQPSVSKFPPIAQMDKRAFAGEEEACLPTELCSNCSHGCKLGLCPEAASHVQEMKDKLIAVSNELLDNASNLSPEQIEKLREDRLQLNKQIQQLERYICDMERQKSHFSASTATRTFLYGTPQTASFSIDPIRFDAQVHLCNEPNGYENWNSSSVSFSSVNNFGVSSGPMEREPYVPKIIEVNYIEGSNDQKWSSRDFPWTKKLEANNKKVFGNHSFRPNQREVINATMSGCDVFVLMPTGGGKSLTYQLPALICPGITLVISPLVSLIQDQIMHLLQANIPAAYLSANMEWTEQQEILRELTSDYCKYKLLYVTPEKVAKSDVLLRHLDSLNARDLIARIVIDEAHCVSQWGHDFRPDYQGLGILKQKFPKTPVLALTATATASVKEDVVQALGLNNCIIFRQSFNRPNLWYSVIPKTKKCVDDIDKFIKENHFDECGIIYCLSRMDCEKVAEKLQECGHKAAFYHGNMDPAQRAAIQKQWSKDEINIICATVAFGMGINKPDVRFVIHHSLPKSIEGYHQECGRAGRDGQRSSCLLYYSYSDYIRVKHMISQGAAEQSPFVSGYSRFNNSGRILETNTENLLRMVSYCENDVDCRRLLQLLHFGEKFDSGNCKKTCDNCCRVKGFVDKDVTNIAKQLVELVKLTGQQFSSSHILEVYRGSLSQFVKKHRHETLSLHGAGKHVAKGEASRILRHLVIEEFLVEDVKKSDIYGSVSSVLKVNESKVQNLCVGGQTIILRFPSTVKATKLSKSEVTPAKGSLTSGKLSPPRVDTPAQSQSKVDLNLSAKLYSALRMLRTVLVKEAGDGVMAYHIFG
Length1042
PositionUnknown
OrganismTheobroma cacao (Cacao) (Cocoa)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> malvids> Malvales> Malvaceae> Byttnerioideae> Theobroma.
Aromaticity0.07
Grand average of hydropathy-0.422
Instability index46.52
Isoelectric point8.13
Molecular weight116989.76
Publications
PubMed=23731509

Function

Annotated function 
GO - Cellular Component
GO - Biological Function
3'-5' DNA helicase activity	GO:0043138	IEA:InterPro
ATP binding	GO:0005524	IEA:UniProtKB-KW
hydrolase activity	GO:0016787	IEA:UniProtKB-KW
nucleic acid binding	GO:0003676	IEA:InterPro

GO - Biological Process
DNA recombination	GO:0006310	IEA:InterPro
DNA repair	GO:0006281	IEA:InterPro
DNA replication	GO:0006260	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP00493
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.17|      15|     134|     432|     447|       2
---------------------------------------------------------------------------
  432-  447 (24.58/16.71)	EANNKKVFGnHSFRPN
  572-  586 (32.59/17.97)	EAHCVSQWG.HDFRPD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     133.69|      40|      63|      86|     125|       4
---------------------------------------------------------------------------
   86-  125 (71.61/48.39)	PGTTAPVKNSNDEISHNWRGRSTLTNSSDMK......WSKHMHVSR
  146-  191 (62.08/40.91)	PSSNANAVEDGNHLQRHSEIKASMSNRSNSKvlggslWNHIVHASQ
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP00493 with Med34 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




NANANA









Molecular Recognition Features






MoRF SequenceStartStop




NANANA