<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP00488

Description Mediator of RNA polymerase II transcription subunit 12 isoform 1
SequenceMQRYHAASCTSAVNNSGIGGASARDTARADSSSLPPNFSLNSRRQTQLSPYKLKCDKEPLNSRLGPPDFHPQSQNCPEETLTRENVQQGYKETIDGLEDSKEISLTQVQAFTKPVVLKCRDAIRKCLRAINESRAQKRKAGQVYGVPLSGALLSKPGVFPEQRPCNEDFRKKWIEGLSQQHKRLRSLADQVPHGYRKKTLIEVLIRNNVPLLRATWFIKVTYLNQVHPGSAISSGAPDKAQLSRTELWTKDVIDYLQTLLDEFFPKSNSHSTQHSRDRLPQMLYAGSLQHRIDSASTILDGGEPSLHFKWWYVVRLLQWHHAEGLVLPSLIIDWLLNQLQVLNLEKELFEILQLLLPIIFGVLETIILCQTYVRNLVGIAIRFIREPSPGGSDLVDNSRRAYTISALVEMLRYLIQAVPDTFVALDCFPLPTCVVSHALNDGGFLSKSSDDAGKIKHNSADAYVLRGKGFDSQYQSLSFDHVVSTIQKRADNLAKGTSAGYPSQSVAKAVQTLDKALLQGDLMEAYKHIFENLCDGAVREGWVAEVSPCLRSSLKWIQTVNLSLICSVFFLCEWATCDFRDFRTAPPRDLKFTGRKDFSQMYLAIQLLKLKIRELQNPEHKNGRASGVNSTAKNISQQNNYSRRNLSGNLFEVKSKVRVVDGRNSNSSDIFDSPGPLHDIIVCWIDQHEGHKGEGGKRLQLFVLELIRSGIFYPQAYVRQLIVSGIIDTNGPVSDFDRRKRHHRILKQLPGQFMCDVLEEARIAVGSELLEAVNVYSNERRLVLHGLLSDQYSNANNAHVSAKKQKYHSTSGRNGASQASGDQRKTVQSSKAFRREVDLEELKASISVLLQFPSLSSASVDSGVDESQGSVKRPIGSTCNKMDLFEVTPGCEDCRRVKRQKLSEEKSSYLQVPSPIPSDDEDTWWVRKGPKNLEPFKVDPPLKSTKQVSRGRQKTVRKTQSLAQLAAARIEGSQGASTSHVCDNKISCPHHRTEVETLKPVDGIRITHSGDIISIGKGLKQLRFVEKRIVTVWLISVVRQLVEESEKSVAKVGQYGRPFVVADEKSPLRWKLGEDELSTILYLMDVSCDLPSAVKFLLWLLPKVISNPSPTIQSGRNILMVPRNVENHACEVGEAYLLSSLRRYENILIAADLIPEALAATMHRAAAVMASNGRITGSGTLVFARYLLKRYGNIASVIEWEKNFKATCDNRLLSELESGQAHDGEFGLPLGVPAGIEDPDDYYRQKLSGARLSRLGLSMRDMVQRHVDDVLHYFLGKERKLFAANAPKGPAIEKGDDGYQVAQQIAIGLLDCIRQTGGAAQEGDPVLVSSAISAIVTNVGPALAKIPDFTGGSNYSNYQPPMNSLNFAKRILRIHLICLSLLKEALGERQSRAFELALGIEASSALAVAFAPAKSSRGQFFLASDAPDTNANISGDNLNGSAKVTLGRTTKMVAAVSALVIGTVIHGVISLDRLVSVLRLREGLDVVQFVRSTKTSSNGNARSVGAFKVDNSVEVCVHWFRLFVGNCRTVCDGLVLELLGEQSVVALSRMQRLLPISLVFPPAYAIFAFVIWKPFILNSNIASREDIHQLYQSLTMAIGDAIKHIPFRDVCMRDSRAFYDILAADTTDAEFAGLPELNGKSMAFVPLRARLFLNAIIDCKMPNSAFTQDDGNRVSGHSEYKALRAESESNLLDKLVRALDTLQPAKFHWQWVELRLLLNEQALIDKTKNQEMSLVDAIRSSSPSSERASPSENEKVLIEIIFTRLLVRPDAAPLFSELVHLFGMSLEDSVLMQAKWFLGGQDVLLGRKTVRQRLINFAEINSRSMKTQFWKPWGWSYSGVDPVTNRGEKKKYEVTSLEEGEVIEEGTESKRYLKGSSQVDVEGSSISLQHVTEKAFSELVLPCIDQSSDDSRNTFASDLIKQFNIIEQQINSVTRGVSKQTGTATSGIEGSTNKGNNRKGIRGSSPGLARRTTATASAESVPPSPAALRASMSLRLQFIVRLLPIICADGEPSTRNMRHMLASVILRLLGSRVVHEDVDLSFNLVQLKRDMELMSSVASSELSGDSLFDRLLLVLHGLLSSSQPSWLGSKPASKHTSEFTGFDREAVESLQNELDSMQLPEMIRWRIQAAMPILFPSFRNLISCHPPSVPIGALSLLQPSIFVPGCYVGNLNAPQRQVPLARNANNILGKSKSMPLLQEYDMEIDPWTLLEDGAGSGPSSNSTVVIGSSDHANLRASSWLKGAVRVRRTDLTYIGAVDDDS
Length2261
PositionKinase
OrganismTheobroma cacao (Cacao) (Cocoa)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> malvids> Malvales> Malvaceae> Byttnerioideae> Theobroma.
Aromaticity0.07
Grand average of hydropathy-0.233
Instability index47.69
Isoelectric point8.82
Molecular weight250414.08
Publications
PubMed=23731509

Function

Annotated function 
GO - Cellular Component
integral component of membrane	GO:0016021	IEA:UniProtKB-KW
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP00488
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     314.05|     105|     225|    1325|    1439|       1
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 1325- 1439 (148.23/117.35)	PV.LVSSAISAIVTNVgpaLAKiPdFTGGSNYSN.......YQPPMNSLNFAKRILRIHLICLS...LLKEALGERQSRAfELAlGIEASSALAVAFAPAkssRGQFFLAS..DAPDTNANISGDNLN
 1555- 1672 (165.82/98.64)	PIsLVFPPAYAIFAFV...IWK.P.FILNSNIASredihqlYQSLTMAIGDAIKHIPFRDVCMRdsrAFYDILAADTTDA.EFA.GLPELNGKSMAFVPL...RARLFLNAiiDCKMPNSAFTQDDGN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     170.12|      51|     523|     685|     752|       3
---------------------------------------------------------------------------
  685-  742 (79.12/66.75)	IDQHEGHKGEGGkrLQLFVleliRSGIFYPQAYVRQLIvSGIIDTNGPVSDFDRRKRH
 1216- 1266 (91.00/55.78)	LESGQAHDGEFG..LPLGV....PAGIEDPDDYYRQKL.SGARLSRLGLSMRDMVQRH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     208.00|      61|    1289|     782|     855|       5
---------------------------------------------------------------------------
  792-  852 (101.19/76.24)	YSNANNAHVSAKKQKYHSTSGRNGASQASGDQRK.........TVQSS............KAFRREVDLEELKASISVLLQF
 1837- 1884 (42.67/14.51)	YSGVDPVTNRGEKKKYEVTSLEEGEVIEEGTESKrylkgssqvDVEGS..................................
 1939- 1998 (64.14/28.71)	............KQTGTATSGIEG.STNKGNNRK.........GIRGSspglarrttataSAESVPPSPAALRASMSLRLQF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     101.98|      31|    1710|     407|     439|       7
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  407-  439 (49.50/40.78)	LVEMLRYLIQ.AVPDTFVA....LDCFPlPTCVVShAL
 2119- 2154 (52.48/33.07)	LPEMIRWRIQaAMPILFPSfrnlISCHP.PSVPIG.AL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     115.36|      37|     171|     909|     950|       9
---------------------------------------------------------------------------
  909-  950 (61.00/56.49)	YL.QVPSPIPSDDEDTWWVRkgPKNL.EPfkvDPPLKSTK...QVSR
 1082- 1123 (54.36/35.40)	YLmDVSCDLPSAVKFLLWLL..PKVIsNP...SPTIQSGRnilMVPR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     124.45|      37|     279|    1774|    1817|      10
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 1781- 1817 (64.59/44.75)	LFGMSLEDSVLMQAKWFL.GGQDVLLGRKTVRQRLINF
 2062- 2099 (59.86/28.37)	LSGDSLFDRLLLVLHGLLsSSQPSWLGSKPASKHTSEF
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP00488 with Med12 domain of Kingdom Viridiplantae
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