<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP00476

Description Mediator of RNA polymerase II transcription subunit 17
SequenceMATEQLADILLTIDPKLVDEHVDAFLLDEDKLTLPQLLPRIIHERGQFTNITESSLEQELRGDSSLPDEDTNMEETDLNSESYPNTSTQTSTTTNEEFYKKKNEVLKHISIALNESSLALDFVSLLISCVRPAAGTISMSSHLKKFVPPGSLNADKVSVQITPEQREDMYKEQKNVGQGWKLSSLESSSTNLRSASARLCEEVQRERVFWDTIKKNFNEKEILYKTRDKTSGKRLFAVKYGYEDSGSTYRITGNAMLKPLQDDRIEFVPLSSRGGGVKRIVRVRILRKEENDDDYSIVGESRTDGGFANDDSIKTRIEKARFFIFEEELFSQLIDEATGLIAYNVKAESESKISIGLQDETIEIEHVEYEEDNVDNGDRAPKPEDDRAEMCVTFLRLMLTVKHKKNLESKKQLTVIKASSSSRNLMKPYSLILRPLVGHFIHEHMIQLLYSMVKNLLHNLDGAQFKLRRYINLNKEELKKDPMKRISEPAVSKFTLKVPQKLKIVLELNSFDLVNFRVNTTTFVSGKKVLESTFEDIRQIEECLEWLIADYSG
Length553
PositionHead
OrganismCyberlindnera fabianii (Yeast) (Hansenula fabianii)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Phaffomycetaceae> Cyberlindnera.
Aromaticity0.07
Grand average of hydropathy-0.519
Instability index45.79
Isoelectric point5.45
Molecular weight63229.03
Publications
PubMed=25103752
PubMed=28385833

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP00476
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     108.05|      34|      70|      87|     120|       1
---------------------------------------------------------------------------
   87-  120 (54.17/34.48)	STQTSTTTNEEFYKKKNEVLKHISIA.LNESSLAL
  158-  192 (53.88/34.27)	SVQITPEQREDMYKEQKNVGQGWKLSsLESSSTNL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     116.18|      30|     295|      53|      84|       3
---------------------------------------------------------------------------
   54-   84 (46.02/32.87)	SSLEQELRgDSSLPDEDTNMEETDL.NSESYP
  325-  349 (28.16/13.52)	..FEEELF..SQLIDEATGLIAYNV.KAES..
  351-  381 (42.00/20.71)	SKISIGLQ.DETIEIEHVEYEEDNVdNGDRAP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.39|      16|      27|     261|     276|       5
---------------------------------------------------------------------------
  261-  276 (29.24/17.78)	QDDRIEFVPLSSRGGG
  291-  306 (29.15/17.71)	NDDDYSIVGESRTDGG
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP00476 with Med17 domain of Kingdom Fungi
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