<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP00450
Description |
Mediator of RNA polymerase II transcription subunit 1 |
Sequence | MYLYLKYLIFCPSVVGSKSFISDLHSKYAEKTWNETFKLVRRCMDKSRGDTKPCEPLIRCLKILHEALNVSSLSAMVSRLEIMAKQRGMGSHLSPTETTCYLTADMFYLEVLLLPGGEVEDVKLAQHGEAPVSSESLLQLLKSKKFEEFSVKLKGLFSLYSIPGENETKIKVYTALQFLGKDLQKISHLPRLVKSLRECNLQVDMILNGRIGYLTAGSEGIPMTIQYYISPSDILLEMSDSERGSVGQLALVTVGPTDSTHKLQMASVIPQPPQLDAQGLPLFSPLCEVLSEMMPACFQLKLQPPLPMLSSFVEKLSQITDVAIADADLQWAPFPQLMMTLLGENGGNKTWDGQDAHFLVPLPGKEIHSYVLPGAAWEEAALRGALVSTIPFTHPAHVPALLELLRHQCAINTLLASCITSLRPSPGPVCDLYCEVLPESGSSLSVTFHLSDSDSLSVLLVNVADSRKLTCSLFAVGSESESMDEYVSRVLKRCMSIPVTMRALNRRLSKRTCGEALPACSATISTADDAMGPDTTATAAESAFCLSVAEVNTNPTANPYPCASVCVYSHWMHNNHLPELI |
Length | 581 |
Position | Middle |
Organism | Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi>
Actinopterygii> Neopterygii> Teleostei> Protacanthopterygii> Salmoniformes>
Salmonidae> Salmoninae> Oncorhynchus.
|
Aromaticity | 0.07 |
Grand average of hydropathy | 0.064 |
Instability index | 46.67 |
Isoelectric point | 5.72 |
Molecular weight | 63651.12 |
Publications | PubMed=24755649
|
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364059
|
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP00450
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
3| 395.27| 120| 124| 90| 211| 1
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24- 140 (147.38/89.79) ...............LHSKYAEKTWNETFKLVRRCMDKSRGDTKPCEPLIRCLKILHEAlNVSSLSAMVSRLeimakqrgmGSHLSPTETTCYLTADMFYLEVLLLPGGEVEDVKLAQHGeaPVSSESLLQL
141- 265 (192.77/113.15) LKSKKFEEFSVKLKGLFSLYSIPGENETKIKVYTALQFLGKDLQKISHLPRLVKSLREC.NLQVDMILNGRI....gyltaGSEGIPMTIQYYISPSDILLEMSDSERGSVGQLALVTVG..PTDSTHKLQM
290- 341 (55.13/26.85) LSEMMPACFQLKLQPPLPMLSSFVEKLSQI...TDVAIADADLQW.APFPQLMMTL............................................................................
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 71.83| 22| 120| 267| 289| 3
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267- 289 (36.68/23.81) SVIP..QPPQLDAQgLPLFSPLCEV
388- 411 (35.15/17.99) STIPftHPAHVPAL.LELLRHQCAI
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 47.83| 13| 15| 536| 548| 5
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536- 548 (21.90/12.26) TATAAESAFCLSV
553- 565 (25.93/15.84) TNPTANPYPCASV
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