<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP00408

Description Uncharacterized protein
SequenceMPIDFLSRLLISVLSVLLPQVRAKVREIEEQVKDRGQAVEFRWSFDKCQETTAGFTIGRVLHTLEVLDNHSFEKSDFSNSLDSLYNRIFGSGQSKDGHEMSPDDDAVVTLLCEWAVCCKRSGRHRAMVVAKLLEKRQAEIEAERCGESEVVDEKGSVSSGSLSAATLPVFQDVLLQFLDTQAPMLTEAGNESERVEFSNLVLLFCELIRHDVFSHNIYMCTLISRGDLASDSHLPRPRSPSDEPSDESERKEQDAGSSVKNEACYDTGLSELMEIDHNSSANFDEMFSPPTHCESKGSPSPEKPAPEQEGKGACKDKALDPAFPLVYEQPRHIQYATHFPIPQEESASHECNQRLVVLYGVGKQRDEARHAIKKITKDILKVLNRKSTAETGGEEGQKRKRTKPEAFPTAEDIFSKFQHLSHFDQHQVTSQVSRNVLEQITSFALGMSYHLPLVQHIQFIFDLMEYSLNISGLIDFAIQLLNELSLVEAELLLKSSSLVGSYTTGLCLCIVAVLRRYHSCLILNPEQTAQVFDGLRIVVKSGVNPADCSSAERCILAYLYDLYTSCCHLKSKFGEIFSEFCSKVKNSIYCNIDPSDSNMLWDPVFMMEAIANPSAHNFNHSMVGKILNDSPANRYSFVCNVLMDVCVDHRDPERQALFFYKTIINNQLLKHPDALKQYRILDLTCQLTRVNDIGILCAELTAYCRSLSAEWLGVLKALCCSSNNGNCGFNDLLCNVDVSDLSFHDSLATFVAILIARQCLLLEDLVRCVAIPSLLNAACSEQDSEPGARLTCRILLHLFKTPQRNPCPQDGAKSDKSSVGIRSSCDRHLLAASQNSIVVGAVFAVLKAVFMLGDAELKGSGFSHPAALDDIADDDMGSKKSGGRTVSIETASLDVYAKYVLKSICQQEWVGERCLRSLSEDSSALQDPVLVNIQAQRLLQLICYPHRQLDSEEGDNPQRQRIKHILQNMDQWTMRQSSLELQLMIKQSTNNELYSLLENIAKATIEVFQKSAEMNSTNLSGNGSAGAGGSASNSNNPSKKPVLSSSERSGVWLVAPLIAKLPTSVQGHVLKAAGEELEKGQHLGSSSRKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLTSLYSQVQQIVTNWREDQYQDDCKAKQMMHEALKLRLNLVGGMFDTVQRSTQQTTEWAVLLLDIISSGTVDMQSNNELFTTVLDMLSVLINGTLAADMSSISQGSMEENKRAYMNLVKKLRKELGDRQSESLEKVRQLLPLPKQTRDVITCEPQGSLIDTKGNKIAGFEKEGLQVSTKQKISPWDVFEGLKHSAPLSWGWFGTVRVDRKVTKFEEQQRFLLYHTHLKPKPRSYYLEPLPLPPEDEEPPTPAPQEPEKKMAEPVKPEKSVPAVSSDSTKKKTKKKKTPSTNKTEDYVTRTQGGLPYGTCIPPDPLMGQQAHPYSRIGYNQQPMGMYAQNQPLPPGGPGLDTPYRPARNPQMGKMMPTRPSYPGMMPGMQGGMPGMMGMDKQYPMGYKPQPNIPQGQILRQQLQVRLNQSMIGPQMRQMTPNQQYSSMQPSQAKHLPGIYHVRLPHWDAATPLSGGWYSPSIVWEPGLPGQPPGGQPGRGGLSEAEAQRLCSPAGTGLLTHHAEHTKVSPPVHPASSRHAALEPHGGPPGHETKPDAGRAAAATAGPAATSPAATAAVPQTAGTQSPAAGSATTTAAAAGSATTTAAAGSTTAAAGSATAAAGXXPSLCGPTHDKPSQLG
Length1754
PositionKinase
OrganismOncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Teleostei> Protacanthopterygii> Salmoniformes> Salmonidae> Salmoninae> Oncorhynchus.
Aromaticity0.06
Grand average of hydropathy-0.393
Instability index50.54
Isoelectric point6.27
Molecular weight192480.59
Publications
PubMed=24755649

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
beta-catenin binding	GO:0008013	IEA:InterPro

GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP00408
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     128.81|      23|      23|    1684|    1706|       1
---------------------------------------------------------------------------
 1625- 1649 (29.42/11.32)	CSPAG......TGLLTHHAeHTKvS.PPVHPA
 1651- 1674 (35.20/14.97)	SRHAA......LEPHGGPP.GHE.TkPDAGRA
 1684- 1706 (41.31/18.83)	TSPAA......TAAVPQTA.GTQ.S.PAAGSA
 1708- 1732 (22.88/ 7.18)	TTAAAagsattTAA....A.GST.T.AAAGSA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     109.56|      23|      24|    1368|    1390|       2
---------------------------------------------------------------------------
 1365- 1387 (42.39/23.02)	PLPPEDE...EP..PTPAPQEPEKKMAE
 1388- 1412 (29.78/13.72)	PVKPEKS...VPavSSDSTKKKTKKKKT
 1466- 1490 (37.39/19.33)	PLPPGGPgldTP..YRPA.RNPQMGKMM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     125.39|      36|     141|     561|     596|       3
---------------------------------------------------------------------------
  561-  596 (67.41/37.04)	DLYTSCCHLKSKFGEIFSEFCSKVKNS......IYCNIDPSD
  699-  740 (57.98/30.92)	ELTAYCRSLSAEWLGVLKALCCSSNNGncgfndLLCNVDVSD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      85.29|      26|      31|     776|     803|       4
---------------------------------------------------------------------------
  776-  803 (42.02/31.75)	NAACSEQDSEPGARLTCRIllHLFKTPQ
  809-  834 (43.26/26.52)	QDGAKSDKSSVGIRSSCDR..HLLAASQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.88|      13|      31|     443|     455|       5
---------------------------------------------------------------------------
  443-  455 (24.12/13.63)	FALGMSYHLPLVQ
  476-  488 (20.76/10.76)	FAIQLLNELSLVE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     100.87|      29|      31|     900|     928|       6
---------------------------------------------------------------------------
  900-  928 (50.46/29.78)	VLKSICQQEWVGERCLRSLSEDSSALQDP
  929-  957 (50.41/29.74)	VLVNIQAQRLLQLICYPHRQLDSEEGDNP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     133.91|      25|      31|    1548|    1572|       7
---------------------------------------------------------------------------
 1496- 1509 (21.51/ 7.87)	.............YP.GM..MPGMQGGMPG
 1510- 1526 (33.23/16.61)	M....MGM..DKQY.......PMGYKPQPN
 1548- 1572 (49.36/28.63)	PQMRQMTP..NQQYS.SM..QPSQAKHLPG
 1579- 1604 (29.80/14.05)	PHWDAATPlsGGWYSpSIvwEPG....LPG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     100.04|      33|     135|    1096|    1144|       8
---------------------------------------------------------------------------
  619-  660 (47.23/18.65)	NHSMvgKILNDSPanrysFVCNVLmdVCVDHRDPERQALF..FY
 1096- 1130 (52.81/52.86)	QKSM..SLLSQQP.....FLSLVL..TCLKGQDEQREGLLtsLY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.24|      21|      24|    1178|    1200|       9
---------------------------------------------------------------------------
 1178- 1200 (30.70/34.42)	QQTTewAVL.LLDIISSGTV..DMQS
 1203- 1226 (26.54/19.23)	ELFT..TVLdMLSVLINGTLaaDMSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     154.52|      44|      81|     303|     346|      10
---------------------------------------------------------------------------
  303-  346 (81.39/55.09)	KPAPEQEGKGACKDKALDP.AFPLVYEQPRHIQYATHFPIPQEES
  386-  430 (73.12/48.64)	KSTAETGGEEGQKRKRTKPeAFPTAEDIFSKFQHLSHFDQHQVTS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.18|      17|     144|    1266|    1283|      12
---------------------------------------------------------------------------
 1242- 1258 (26.27/10.22)	LVKKLRKELGDRQSESL
 1267- 1283 (29.91/12.95)	LPKQTRDVITCEPQGSL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.66|      14|      15|    1286|    1300|      13
---------------------------------------------------------------------------
 1286- 1300 (20.41/17.14)	TKgNKIAGFEK.EGLQ
 1303- 1317 (22.26/12.77)	TK.QKISPWDVfEGLK
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP00408 with Med12 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) ASDSHLPRPRSPSDEPSDESERKEQDAGSSVKNE
2) FDEMFSPPTHCESKGSPSPEKPAPEQEGKGACKDKALDP
3) PSIVWEPGLPGQPPGGQPGRGGLSEAEAQRLCSPAGTGLLTHHAEHTKVSPPVHPASSRHAALEPHGGPPGHETKPDAGRAAAATAGPAATSPAATAAVPQTAGTQSPAAGSATTTAAAAGSATTTAAAGSTTAAAGSATAAAGXXPSLCGPTHDKPSQLG
4) SAEMNSTNLSGNGSAGAGGSASNSNNPSKKPVL
5) SYYLEPLPLPPEDEEPPTPAPQEPEKKMAEPVKPEKSVPAVSSDSTKKKTKKKKTPSTNKTEDYVTRTQGGLPYGTCIPPDPLMGQQAHPYSRIGYNQQPMGMYAQNQPLPPGGPGLDTPYRPARNPQMGKMMPTRPSYPGMMPGMQGGMPGMMGMDKQYPMGYKPQPNIPQGQILRQQLQVRLNQSMIGPQMRQMTPNQQYSSMQPSQAKHLPGIYHVRLP
229
283
1594
1011
1358
262
321
1754
1043
1579










Molecular Recognition Features






MoRF SequenceStartStop




NANANA