<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP00389

Description Mediator of RNA polymerase II transcription subunit 19
SequenceMTEMFSTLYGQNDAQGPPRSSSLGFGPGNPPPPLPPNQVPMAAQMPPQLGDEGPALRKPGAMNEPFYLLRELPVGNELTGNTNLITHYNLEHAYNKFCGKKVKEKLSNFLPELPGMIDWPGTQDGSSLRSLIEKPPVCGNSFSPLTGASLTGFRLHTGPLPEQYRLMHIQPPKKKSKHKHKHNRPQDPIPQETPSDSDPKKKKKKRDDDPDRKKKKKDKKKKKNRHSPDHPGLAGSQPNSLR
Length242
PositionHead
OrganismOncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Teleostei> Protacanthopterygii> Salmoniformes> Salmonidae> Salmoninae> Oncorhynchus.
Aromaticity0.05
Grand average of hydropathy-1.140
Instability index55.14
Isoelectric point9.80
Molecular weight26932.48
Publications
PubMed=24755649

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU366036
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats
>MDP00389
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      75.90|      15|      17|     198|     212|       1
---------------------------------------------------------------------------
  172-  190 (18.95/ 6.85)	.PKKKskhkhKHNRPQDPIP
  198-  212 (30.19/15.03)	DPKKK.....KKKRDDDPDR
  218-  230 (26.76/12.53)	D.KKK.....KKNR.HSPDH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.83|      16|      21|      28|      46|       2
---------------------------------------------------------------------------
   28-   46 (28.57/18.05)	GNPPPPLppnQVPMAAQMP
   50-   65 (30.25/11.42)	GDEGPAL...RKPGAMNEP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.58|      16|      21|     111|     128|       3
---------------------------------------------------------------------------
  111-  128 (28.10/20.52)	PELPGMIDWPGTqdGSSL
  135-  150 (31.47/16.63)	PPVCGNSFSPLT..GASL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP00389 with Med19 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) ASLTGFRLHTGPLPEQYRLMHIQPPKKKSKHKHKHNRPQDPIPQETPSDSDPKKKKKKRDDDPDRKKKKKDKKKKKNRHSPDHPGLAGSQPNSLR
2) FLPELPGMIDWPGTQDGSSLRSLIEKPPVCGNSFSPLT
3) MFSTLYGQNDAQGPPRSSSLGFGPGNPPPPLPPNQVPMAAQMPPQLGDEGPALRK
148
109
4
242
146
58










Molecular Recognition Features






MoRF SequenceStartStop




1) DPKKKKKKRDDDPDRKKKKKDKKKKKNRHSPDH
2) YRLMHIQ
198
164
230
170