Description | Mediator of RNA polymerase II transcription subunit 17 |
Sequence | MEEEPPWKKLKLSLERPYKDDSGQPLPELLDITPDGQQIYRPREDPTAVVGTKLRRIFLERGTDFFEAQNGSRVFPPPQTRDASTQAEDATDGEKRAESTHAMTPEELYKLRGKDRSLRAAADLFKSAAEKMEDSRLAGERYWLDALKIRRENWGLIPAPLPLGSATGKGADKTSKDFLISFGLEEAPPAFRRRAIGRIAAMDSANTEHPLEFPLRQRTRLRASLTRTRSDGSKETRHSRLTHLNDGSLDGALRAAQAEVVEQEIFSVLIKEASSLPTASAEVSERLIVLDAAQNTELRFELVDSDCMALQQSEDADPLCDLIFMSSHILLLRAHAALKTRRLQKTSISRTVVAAPAAQPPSLLQPIIDMLQYREFWERVYLPGYTTIRWRTAAKLSWLPYKARRRAWWEAKSSSK |
Length | 416 |
Position | Head |
Organism | Pycnoporus cinnabarinus (Cinnabar-red polypore) (Trametes cinnabarina) |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Basidiomycota> Agaricomycotina> Agaricomycetes> Polyporales> Polyporaceae> Trametes. |
Aromaticity | 0.07 |
Grand average of hydropathy | -0.579 |
Instability index | 54.83 |
Isoelectric point | 8.88 |
Molecular weight | 46991.81 |
Publications |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364140 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP00376 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 65.18| 18| 252| 136| 154| 3 --------------------------------------------------------------------------- 136- 154 (30.38/23.40) RLAGERYWLdALKIRRENW 391- 408 (34.80/21.73) RTAAKLSWL.PYKARRRAW --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 83.42| 26| 28| 182| 209| 4 --------------------------------------------------------------------------- 182- 209 (39.49/34.76) FGLEEAPPAfrRRAIGRIAAMDSANTEH 213- 238 (43.92/30.68) FPLRQRTRL..RASLTRTRSDGSKETRH --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) FRRRAI 2) KLRRIFLER 3) MEEEPPWKKLKLSLERPYKDDSGQPLPELLDI 4) QIYRPRE | 191 53 1 38 | 196 61 32 44 |
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