<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP00364
Description |
Uncharacterized protein |
Sequence | MAANYWTSTQRRFWLFDREQLAETRAALDEADRAFIAQYPLPDHRLVNIYINQQLIKLGKRMNTRQQALATAQVYVKRFFTKVSIRRTNPYLLLTTAFYLACKTEECPQHIKYVVSEARGLWPEFILSDSAKVGECEFWLISELNSQLIVHHPYRTLSDFSSTLTNTASSGLTLSSDEIALAWSVVNDSYLTDLPLLQPPHVIAVMAVFVAVVFKPGTSSSSSSASTGAAAVAAAAGPGTLASASASTGTGTGPGTGTTSSAGMAAGIREGMGDGGRVQKVVEWLAGSEVSIEAVVECTQEMVALYEVWEGYGEKGLREAIGRYVRGRFLDK |
Length | 332 |
Position | Kinase |
Organism | Trichophyton interdigitale (strain MR816) |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes>
Eurotiomycetidae> Onygenales> Arthrodermataceae> Trichophyton.
|
Aromaticity | 0.09 |
Grand average of hydropathy | -0.024 |
Instability index | 35.88 |
Isoelectric point | 6.25 |
Molecular weight | 36138.59 |
Publications | |
Function
Annotated function |
Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex. The SRB8-11 complex
phosphorylates the C-terminal domain (CTD) of the largest subunit of
RNA polymerase II.
Component of the srb8-11 complex. The srb8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The srb8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex. The srb8-11 complex
phosphorylates the C-terminal domain (CTD) of the largest subunit of
RNA polymerase II.
ECO:0000256 ARBA:ARBA00002306
ECO:0000256 ARBA:ARBA00003882
|
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | cyclin-dependent protein serine/threonine kinase regulator activity GO:0016538 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP00364
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
3| 67.87| 17| 31| 217| 234| 1
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217- 234 (25.51/15.52) GTSSSSSSASTGaAAVAA
239- 250 (21.09/ 8.42) GT.LASASASTG.....T
255- 266 (21.27/ 8.53) GTGTTSS......AGMAA
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 60.97| 18| 32| 86| 107| 3
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86- 107 (27.44/29.34) RRTNPYLLLTTafylACKTEEC
119- 136 (33.53/22.72) RGLWPEFILSD....SAKVGEC
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|