<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP00346

Description Mediator of RNA polymerase II transcription subunit 14 (Fragment)
SequenceMAGAELGQQTVEFSALVGRAAEESFSSLKELVEKSKSGDQSDTEKKISLLKYLVKTQQRMLRLNVLAKWCKQVPLIQYCQQLSSTLSSHDTCFTQAADSLFFMHEGLQQARAPAYDVPSAIQVLLTGNYQRLPKCIEDVGAQGVLTEEEQKPVLKKLDTLVRTKLLELSIPKEISEVKVSDGTVLLSVDGEFKVLVTLGYRGHLSMWRILHLELLVGEKSGPIKLEESRKHVLGDDLERRMSVAENPFLTLYSVLHELCIALVMDTVIRQVQLLRQGRWKDAIRFELISDGGPSHTGPSSSQINQDGEVDSASLRTPGLKIMYWLDFSKGSGTSDSCPYVKIEPGPDLQIKCLHSTFVIDPLTGKEAEFSLDQSCINVEKLLLRAICCNRYTRLLEIQKELAKNSQICRVAGDVTLLSHTDELDVDFKKKYTEYEGHEVLHVRAYGSAFFTLGINIRNGRFLLRSTQNILSPSALSECEEALNQGSINSAEGFMSLRSKSILHLFASISRFLGLEVYENNFAAVKIPKSIANDSAMLLLGFPDCGSSYFLLMQLDNDFKPLLKLIETQPDMSGKINSLVTRIVQPV
Length586
PositionTail
OrganismEucalyptus grandis (Flooded gum)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> malvids> Myrtales> Myrtaceae> Myrtoideae> Eucalypteae> Eucalyptus.
Aromaticity0.07
Grand average of hydropathy-0.111
Instability index36.08
Isoelectric point6.02
Molecular weight65330.51
Publications
PubMed=24919147

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
core mediator complex	GO:0070847	IBA:GO_Central
mediator complex	GO:0016592	IBA:GO_Central

GO - Biological Function
transcription coregulator activity	GO:0003712	IBA:GO_Central

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP00346
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     537.92|     181|     222|     163|     361|       1
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  163-  361 (269.09/207.85)	TKLLElsIPKEI...SEV.KVSDGTVLLSVDGEFKVLVTLGYRGHLSMwRILHLElLVGekSGPIKLEESRKHvlGDDLERRMSVAENPfltlySVLHElCIALVMDTVIRQVQLLRQGRWKDAIR.FELISD..GGPSHTGP.SSSQINQDGEVDSASLRT..PGLKIMYWLDFSKgsgTSDSCPYVK.IEPGPDLQIKcLHS..TFVIDP
  392-  585 (268.83/159.24)	TRLLE..IQKELaknSQIcRVAGDVTLLSHTDELDVDFKKKYTEYEGH.EVLHVR.AYG..SAFFTLGINIRN..GRFLLRSTQNILSP.....SALSE.CEEALNQGSINSAEGFMSLRSKSILHlFASISRflGLEVYENNfAAVKIPKSIANDSAMLLLgfPDCGSSYFLLMQL...DNDFKPLLKlIETQPDMSGK.INSlvTRIVQP
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP00346 with Med14 domain of Kingdom Viridiplantae
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