<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP00254

Description Uncharacterized protein
SequenceMEKESIVERQEQKPVVDSTQSGNYNLVNFNLEEVEEEIRLEKIRQASVKFSWDYLSQLLRRNLMEKRFVLSADDKEDLMQAVADMRKHMPSDSDRDLSTHLRHLAESLSSDFQAHPGYYKIRNTDFSLEVTVSADGQQITSCSISWFGERAMEAQALRLYISRNRWDLVHTALTAMFHLVPSDLSRDDKIYCLRSLEYAEKDLLNMSGSAPSIFEQINGDILGLCKPRTESTPFTIYPFVEPVIFFDTTSGSIVPPTDEQVLYDVEPYLQLCIVSNSTPNFFSDSTLFAHGEWRTAVSGRQLPAAFCLRFSRPIIFSSAAIKKLSKIALVQLDVEGSYNLYQYLLNENEECHDLFVRLPGCSTQHYIFDNSMMCSREDGILRQIPFAHLQDVVFLVNIIRTQLAHNAFFESLVRAHSRSACVDENIVDIRIASSYIDFFDLQFYLKKNLFIARVAVSPSNTNVSLECVINGAVLPESQHATAILTKSWSLAIMMRSVLRRGGAISLAALEKPFVMNENVDNNCDVKISQSWLFVPNITDSSINYNKIEHEYVVDERINLNYSHDNNTLGRQSPLSLLALFKELEKIEELIPPQKPMNGAQQCTAPPRNEMLAPRTSRIHSENTMTINAFSVLDAICDMAANIDDGESNVSEHSSHSSTSQRLRPQIPPQSPSPASERYRTSQAANFSQLSPLDIARQRLAQQAPMSNPTDVFEFDDPPRMTSASSMATSTQQFHFPEAGQSPYSFAAMQTTRGSLNVQPTLKRRGRGRKAGNVGDRMLDPTRPILDQNTGLIFRGMNIPTRKPRGTSTARRPRRPRKAAHMPVSPVHSHQFAINRPMLQRSFSEMPAYPSQMPSASLSQENRSEASEFDGTEESSDDETDPPPPACATTVPQPSAQFTARSSTPIAQTTTVTSLSSSSATLSLINKSSSLTATSCFPSTSSSGAATELTPPANSSPTSTNNGSVQSAALLAHKARKGSLEAVVGKLHCKTAPTSSSSSTTSNPYLASDLYDDESEPVSKPPEQPAPTKRDSPSVLTSSPGARMSPNLTKINAEQPGYGSELKIMIKLKQQAPTRPSIGPSQSSSGGVPSSMRLVGQPPSSSRSKEEKALLRQKQLKEKNRSASDERARKAGKRERKGEFNSSIKKLKLDRPLSEQKTMTISPKVEFPQALAFASLKNFKIPKVMENEKCESPTPTTTTAPAVATPSSSGAHLNVSQNSSSSTVQAVSSTSLSATLTTTPSSSSSSGTSSIFPPKPKSILKSSVDPPPPPLFRGMGGMPPMLPGRRPLLPDPRNVMHHPPRLEHILNQFRPLVTLPRMAPSVLGGGNFMPPPSSSGRWMALAPQRQPSPKNSPSEQSVSNSGLSDTAAAMSKMQDSPTETLKIVADEE
Length1387
PositionMiddle
OrganismOnchocerca volvulus
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Chromadorea> Rhabditida> Spirurina> Spiruromorpha> Filarioidea> Onchocercidae> Onchocerca.
Aromaticity0.06
Grand average of hydropathy-0.472
Instability index62.58
Isoelectric point8.26
Molecular weight152543.41
Publications









Function






Annotated function


GO - Cellular Component
GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP00254
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     177.19|      31|      31|    1256|    1286|       1
---------------------------------------------------------------------------
  753-  783 (27.97/10.76)	.....GSLNVQPTLK......RRGRGRKagnvgDRMLD.....PTRP
  784-  812 (28.24/10.94)	..IL....DQNTGLI......FRGM.NI.....PTRKPrgtstARRP
 1256- 1286 (60.40/32.65)	KSILKSSVDPPPPPL......FRGMGGM.....PPMLP.....GRRP
 1292- 1319 (27.46/10.41)	RNVMH.....HPPRLehilnqFRPLVTL.....PRMAP.........
 1320- 1345 (33.12/14.23)	.SVLGGGNFMPPP.........SSSGRW.....MALAP.....QRQ.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     370.30|      65|      65|     819|     883|       2
---------------------------------------------------------------------------
  819-  881 (103.92/50.40)	..........AHMPVSPVHSHQF..AINR..PMLQ.........R....SFSEMPA........YPS....................................QM..PSASLSQENRS..EA....SE.....FDGTEESS...DDETD..P
  882-  950 (61.15/26.22)	PP.......pACATTVPQPSAQF..TARSstPIAQ.........TttvtSLS..............S....................................S....SATLSLINKS..SSltatSC.....FPSTS.SS...GAATEltP
  951- 1016 (53.35/21.82)	PA........NSSPTST..........NN..GSVQsaallahkaR....KGS.LEA........VVG....................................KLhcKTAPTS....S..SS....ST.....TSNPYLASdlyDDESE..P
 1020- 1126 (49.52/19.65)	PP..eqpaptKRDSPSVLTSSPG..ARMS..PNLT.........K....INAEQPG........YGSelkimiklkqqaptrpsigpsqsssggvpssmrlvgQP..PSSSRSKEEKAllRQ....KQ.....LKEKNRSA...SDER....
 1127- 1199 (59.49/25.28)	..........ARKAGKRERKGEFnsSIKK..LKLD.........R....PLSEQKTmtispkveFPQ....................................AL..AFASLKNFKIP..KV....ME.....NEKCESPT...PTTTT..A
 1200- 1252 (42.87/15.89)	PAvatpsssgAHLNVS............Q.....N.........S....SSSTVQA........VSS....................................TS..LSATLTTTPSS..SS....SSgtssiF.................P
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      91.97|      27|     113|     593|     619|       3
---------------------------------------------------------------------------
  593-  619 (51.52/26.74)	QKPMNGAQ...QCTAPPR...NEMLAPRTSRIH
  702-  734 (40.44/19.33)	QAPMSNPTdvfEFDDPPRmtsASSMATSTQQFH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     169.20|      54|      69|     187|     245|       4
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  187-  245 (80.91/68.27)	DDKIycLRSLE.YAEkdLLNMSGSAPSIFEQ....INGDILGLCKPRTESTPFTIYpFVEPVIF
  258-  316 (88.29/54.99)	DEQV..LYDVEpYLQ..LCIVSNSTPNFFSDstlfAHGEWRTAVSGRQLPAAFCLR.FSRPIIF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      76.40|      24|     335|     123|     146|       6
---------------------------------------------------------------------------
  123-  146 (43.25/32.10)	NTDFSLEVTVSA....DGQQITS.CSISW
  460-  488 (33.15/22.70)	NTNVSLECVINGavlpESQHATAiLTKSW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.22|      13|      94|     422|     435|       8
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  422-  435 (17.80/17.25)	VDENiVDIRIASSY
  519-  531 (25.41/18.63)	VDNN.CDVKISQSW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.19|      19|     313|      22|      40|      10
---------------------------------------------------------------------------
   22-   40 (34.26/22.95)	GNYNLVNFNLEEVEE....EIRL
  336-  358 (29.93/19.19)	GSYNLYQYLLNENEEchdlFVRL
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP00254 with Med1 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) ANIDDGESNVSEHSSHSSTSQRLRPQIPPQSPSPASERYRTSQAANFSQLSPLDIARQRLAQQAPMSNPTDVFEFDDPPRMTSASSMATSTQQFHFPEAGQSPYSFAAMQTTRGSLNVQPTLKRRGRGRKAGNVGDRMLDPTRPILDQNTGLIFRGMNIPTRKPRGTSTARRPRRPRKAAHMPVSPVHSHQFAINRPMLQRSFSEMPAYPSQMPSASLSQENRSEASEFDGTEESSDDETDPPPPACATTVPQPSAQFTARSSTPIAQTTTVTSL
2) AVVGKLHCKTAPTSSSSSTTSNPYLASDLYDDESEPVSKPPEQPAPTKRDSPSVLTSSPGARMSPNLTKINAEQPGYGSELKIMIKLKQQAPTRPSIGPSQSSSGGVPSSMRLVGQPPSSSRSKEEKALLRQKQLKEKNRSASDERARKAGKRERKGEFNSSIKKLKLDRPLSEQKTMTISPKVEF
3) IPPQKPMNGAQQCTAPPRNEMLAPRTSRIH
4) PKVMENEKCESPTPTTTTAPAVATPSSSGAHLNVSQNSSSSTVQAVSSTSLSATLTTTPSSSSSSGTSSIFPPKPKSILKSSVDPPPPPLFRGMGGMPPMLPGRRPLLPDPRNVMHHPPRLEHILNQFRP
5) SCFPSTSSSGAATELTPPANSSPTSTNNGSVQSAALLAHKARK
6) VTLPRMAPSVLGGGNFMPPPSSSGRWMALAPQRQPSPKNSPSEQSVSNSGLSDTAAAMSKMQDSPTETLKIVADEE
640
981
590
1181
934
1312
914
1166
619
1310
976
1387










Molecular Recognition Features






MoRF SequenceStartStop




1) EEKALLRQKQLKEK
2) ETLKIVAD
3) SIKKLKLDR
4) YGSELKIMIKLKQQAP
1105
1378
1142
1057
1118
1385
1150
1072