<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP00254

Description Uncharacterized protein
SequenceMEKESIVERQEQKPVVDSTQSGNYNLVNFNLEEVEEEIRLEKIRQASVKFSWDYLSQLLRRNLMEKRFVLSADDKEDLMQAVADMRKHMPSDSDRDLSTHLRHLAESLSSDFQAHPGYYKIRNTDFSLEVTVSADGQQITSCSISWFGERAMEAQALRLYISRNRWDLVHTALTAMFHLVPSDLSRDDKIYCLRSLEYAEKDLLNMSGSAPSIFEQINGDILGLCKPRTESTPFTIYPFVEPVIFFDTTSGSIVPPTDEQVLYDVEPYLQLCIVSNSTPNFFSDSTLFAHGEWRTAVSGRQLPAAFCLRFSRPIIFSSAAIKKLSKIALVQLDVEGSYNLYQYLLNENEECHDLFVRLPGCSTQHYIFDNSMMCSREDGILRQIPFAHLQDVVFLVNIIRTQLAHNAFFESLVRAHSRSACVDENIVDIRIASSYIDFFDLQFYLKKNLFIARVAVSPSNTNVSLECVINGAVLPESQHATAILTKSWSLAIMMRSVLRRGGAISLAALEKPFVMNENVDNNCDVKISQSWLFVPNITDSSINYNKIEHEYVVDERINLNYSHDNNTLGRQSPLSLLALFKELEKIEELIPPQKPMNGAQQCTAPPRNEMLAPRTSRIHSENTMTINAFSVLDAICDMAANIDDGESNVSEHSSHSSTSQRLRPQIPPQSPSPASERYRTSQAANFSQLSPLDIARQRLAQQAPMSNPTDVFEFDDPPRMTSASSMATSTQQFHFPEAGQSPYSFAAMQTTRGSLNVQPTLKRRGRGRKAGNVGDRMLDPTRPILDQNTGLIFRGMNIPTRKPRGTSTARRPRRPRKAAHMPVSPVHSHQFAINRPMLQRSFSEMPAYPSQMPSASLSQENRSEASEFDGTEESSDDETDPPPPACATTVPQPSAQFTARSSTPIAQTTTVTSLSSSSATLSLINKSSSLTATSCFPSTSSSGAATELTPPANSSPTSTNNGSVQSAALLAHKARKGSLEAVVGKLHCKTAPTSSSSSTTSNPYLASDLYDDESEPVSKPPEQPAPTKRDSPSVLTSSPGARMSPNLTKINAEQPGYGSELKIMIKLKQQAPTRPSIGPSQSSSGGVPSSMRLVGQPPSSSRSKEEKALLRQKQLKEKNRSASDERARKAGKRERKGEFNSSIKKLKLDRPLSEQKTMTISPKVEFPQALAFASLKNFKIPKVMENEKCESPTPTTTTAPAVATPSSSGAHLNVSQNSSSSTVQAVSSTSLSATLTTTPSSSSSSGTSSIFPPKPKSILKSSVDPPPPPLFRGMGGMPPMLPGRRPLLPDPRNVMHHPPRLEHILNQFRPLVTLPRMAPSVLGGGNFMPPPSSSGRWMALAPQRQPSPKNSPSEQSVSNSGLSDTAAAMSKMQDSPTETLKIVADEE
Length1387
PositionMiddle
OrganismOnchocerca volvulus
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Chromadorea> Rhabditida> Spirurina> Spiruromorpha> Filarioidea> Onchocercidae> Onchocerca.
Aromaticity0.06
Grand average of hydropathy-0.472
Instability index62.58
Isoelectric point8.26
Molecular weight152543.41
Publications









Function






Annotated function


GO - Cellular Component
GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP00254
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     177.19|      31|      31|    1256|    1286|       1
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  753-  783 (27.97/10.76)	.....GSLNVQPTLK......RRGRGRKagnvgDRMLD.....PTRP
  784-  812 (28.24/10.94)	..IL....DQNTGLI......FRGM.NI.....PTRKPrgtstARRP
 1256- 1286 (60.40/32.65)	KSILKSSVDPPPPPL......FRGMGGM.....PPMLP.....GRRP
 1292- 1319 (27.46/10.41)	RNVMH.....HPPRLehilnqFRPLVTL.....PRMAP.........
 1320- 1345 (33.12/14.23)	.SVLGGGNFMPPP.........SSSGRW.....MALAP.....QRQ.
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     370.30|      65|      65|     819|     883|       2
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  819-  881 (103.92/50.40)	..........AHMPVSPVHSHQF..AINR..PMLQ.........R....SFSEMPA........YPS....................................QM..PSASLSQENRS..EA....SE.....FDGTEESS...DDETD..P
  882-  950 (61.15/26.22)	PP.......pACATTVPQPSAQF..TARSstPIAQ.........TttvtSLS..............S....................................S....SATLSLINKS..SSltatSC.....FPSTS.SS...GAATEltP
  951- 1016 (53.35/21.82)	PA........NSSPTST..........NN..GSVQsaallahkaR....KGS.LEA........VVG....................................KLhcKTAPTS....S..SS....ST.....TSNPYLASdlyDDESE..P
 1020- 1126 (49.52/19.65)	PP..eqpaptKRDSPSVLTSSPG..ARMS..PNLT.........K....INAEQPG........YGSelkimiklkqqaptrpsigpsqsssggvpssmrlvgQP..PSSSRSKEEKAllRQ....KQ.....LKEKNRSA...SDER....
 1127- 1199 (59.49/25.28)	..........ARKAGKRERKGEFnsSIKK..LKLD.........R....PLSEQKTmtispkveFPQ....................................AL..AFASLKNFKIP..KV....ME.....NEKCESPT...PTTTT..A
 1200- 1252 (42.87/15.89)	PAvatpsssgAHLNVS............Q.....N.........S....SSSTVQA........VSS....................................TS..LSATLTTTPSS..SS....SSgtssiF.................P
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      91.97|      27|     113|     593|     619|       3
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  593-  619 (51.52/26.74)	QKPMNGAQ...QCTAPPR...NEMLAPRTSRIH
  702-  734 (40.44/19.33)	QAPMSNPTdvfEFDDPPRmtsASSMATSTQQFH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     169.20|      54|      69|     187|     245|       4
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  187-  245 (80.91/68.27)	DDKIycLRSLE.YAEkdLLNMSGSAPSIFEQ....INGDILGLCKPRTESTPFTIYpFVEPVIF
  258-  316 (88.29/54.99)	DEQV..LYDVEpYLQ..LCIVSNSTPNFFSDstlfAHGEWRTAVSGRQLPAAFCLR.FSRPIIF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      76.40|      24|     335|     123|     146|       6
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  123-  146 (43.25/32.10)	NTDFSLEVTVSA....DGQQITS.CSISW
  460-  488 (33.15/22.70)	NTNVSLECVINGavlpESQHATAiLTKSW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.22|      13|      94|     422|     435|       8
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  422-  435 (17.80/17.25)	VDENiVDIRIASSY
  519-  531 (25.41/18.63)	VDNN.CDVKISQSW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.19|      19|     313|      22|      40|      10
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   22-   40 (34.26/22.95)	GNYNLVNFNLEEVEE....EIRL
  336-  358 (29.93/19.19)	GSYNLYQYLLNENEEchdlFVRL
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP00254 with Med1 domain of Kingdom Metazoa
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