<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP00249

Description Uncharacterized protein
SequenceMGMKSLNVISWHYQTPERRALKRNRLGPPDVYPQDAKQEEDNLGADRLKKGYQVAVTSYEHESIVYNVKVLFHKNVFWMPRLDRLDDTMLRGAQLVMQIMAKKMELNANLDKERKRAGSVIAKDSIGNGGTGMGGGQQVHFQQFSHNAEKARKSKERNDWFTDLAHGKPLAVLARKPPFFRKKEDALEYLCDYKVPVARALWFLKLIAVGGQGCSSNVNKQKKSTNDQLASEFASLFTKYVKLMLNQMSDSAKLESNIVYTERWPHFVYICKHAYEDGMVEKQEFLMDLLDIFNDRFVQPIENRQNDKSSVHPLVHHGSGLASSSNESHYVTLFRLFLLFICQYTDQITQNLVLSKRCAFLVCHRLELYRDEAEEREGRSVDCAELFDDMQQCIHQRGIILTLCGMLYAILIDCPAALIWNKYEVSPGRPPTMLHQLCGSPLDHLPCPFESLPLPPGHGTERLQEFVQLRLSEVRRRSRACENKWSLNYAQKKGFAAMVLQCLKIVSVLDAARLDQPNCIEKIYAVIFNGPSKESFEHEYAIRVKMLLQWAVTIEREGTHRAILVAQLLAFRINHRKTFKFGPLTLQEILLEFLVTEGPDPESTDKDRFCQEFANLMLLFIELERAGVFSHDFYVKELIRTGEMLEYIPLMQKIRKRKEDKQKQHQQPFNMAISSSTFASQSSEPTAALLAGAGATPPPLVTMPSELPDERPYLWGNLSIHERLLIHLPIPQSAEYRSECNQRSLLLYGIGAERDAVKLELRRLARELAKLWQKRIVVEFSFNKPLEIRFKKRATREQVQESMAKFRSCTYYDQLVICGWCCESFIQMVQDFVDGHSCVLPTAEGLDIVLEMCELAQNIAGIMEFAEELLPLLVLVERVLLERRVDCLPSNISAQLSYVLTAYISHNYYYFLYSQNAPNIVQGLYWVIESQLKSSDSCLTGWGRTVAVFVLDAKKQLIETGLCSRKIEAKRELLKRVVPPWKPTHNIADRNLCGGQRYAYNASTFKELLDEPKRIFSFNEYRRLHAVIDGTDDARYIFVVSALLAAVRGVGSANGNDNAGIGGTTERVTGDRLVELANICGHVTAQAAQAEKYLDWCGALQALCCSSLQGGTSTFPDLLMEINVEDSTCHYNIATFYMLLAGRSCFSINALVHQLLHTALKSLLNCGIGKAPDADAEAGVCLALLVLANVICQSDQPIILSPQYTGERINSNICKADRWILTEGHLHDVGDEVCALLVTICMIADYTKHKLRDRYSDDGKSIDQRAFRREYIAELSKGVLMAMCEQEWVTQRIYRRCEDGAMDCFSSHQLRKNCLGQQLLRMALRRRSEREIVRELTICNGNSKKSLIDKLLNVLNIWNTRATYFDFKLMIREISPEGCTSKHAQQSAIAADALLGEIGKCCRDFFTQSHKFDKKLPPAAVGKAFRLKDITAYWLISPLVHACPRPGNLPASFPAITIQGKFLKEAAAMLDTSSDNNKERIQQSAWLLSQEPFLNLVLTCLNGEEQQRDGLVGSMLKQLQELALKAKDNPLLPYLRIFSLEREGVLLRISLVGGMFDSVCHTSICDTWALTLFQLMLYGVISKERDGYLFDSCYDMLSTLLIWSITDPMNAAAMNAQDPDTKFRFPTYSLIVKKLRKELNERALIPELRSLMQFLPIPKPQFELITCEPYGTVPTSPQKLGKSQMQGQIMQTTVKANRHGLQFAEKVKLSAFDIVPHLNVDSTLLRRPWSWSMLQAVKLDRLPVPVQRYIQRLVHHSHYNEFVRPTICGMDRPPNLDIYLSPPMMDVSETPATLHHVSSNAVTSTTTSASSTNVVVSSCGTSMDVSATLGSVTQSRTMGYQSSATPSCTSVPDGSTPSGAPGASNAATIMIFPGQGGPMSALPDLTGRGQNNASPRGARGGRRKATGLSTRSQGTTRKQRQQRQQTVDQLAVAAAAAAAAAQQQQQQMTGAGPSQQSTYPGTWATGPQQAGVPQQFASGPSATLTGAGQSGAPMGTQPTEDSKMKIHSMILQKRQAQAASGATATQQGITSAAQPAMQDVNTYQISGRPAQYGGGMVMKVETSATSMQMADHTQQQQQQQQQYVQHQQQQQYIQQQQLIQMQQDTQGASQYIVHHQQQRGSLAYGQQSMQQVAYDSRFNQQQLPYGQQPQQQQQQYHPPQQY
Length2162
PositionKinase
OrganismOnchocerca volvulus
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Chromadorea> Rhabditida> Spirurina> Spiruromorpha> Filarioidea> Onchocercidae> Onchocerca.
Aromaticity0.08
Grand average of hydropathy-0.310
Instability index48.74
Isoelectric point8.51
Molecular weight242913.80
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP00249
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     289.69|      94|     131|     579|     709|       1
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  579-  681 (146.14/108.76)	FKFGPLTLQEILLEFLvtegPDPESTDKDRFCQEfANLMLLFIELERAGV.FSHDFYVKELIRTGE...MLEYI...PLMQKIRKRKEDKQKQHqqpfNMA.ISSSTFASQ
  713-  814 (143.55/108.22)	YLWGNLSIHERLLIHL....PIPQSAEYRSECNQ.RSLLLYGIGAERDAVkLELRRLARELAKLWQkriVVEFSfnkPLEIRFKKRATREQVQE....SMAkFRSCTYYDQ
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     326.48|      86|     131|    1927|    2027|       2
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 1872- 1958 (104.43/49.41)	FPG..QGGPMSA.LPD.........LT.GRGQNNAsPRGA.................RGGrRKATGLSTRSQ...................gttrkqrqqrqqtVDQLAVAAAA...AAAAAQQQQQQMTGAGPSQQST
 1959- 2091 (124.34/83.55)	YPGtwATGPQQAGVPQQFASGPSATLT.GAGQSGA.PMGTQPTEdskmkihsmilqkRQA.QAASGATATQQgitsaaqpamqdvntyqisgrpaqygggmvmkVETSATSMQM...ADHTQQQQQQQQQYVQHQQQQQ
 2092- 2161 (97.71/45.77)	Y.....IQQQQLIQMQQDTQGASQYIVhHQQQRGSlAYGQQSMQ.................QVAYDSRFNQQ..........................................qlpYGQQPQQQQQQY...HPPQQ..
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     104.59|      33|     133|     986|    1025|       3
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  986- 1025 (46.28/47.84)	NIADrNLCggqryAYNASTFKELLdEPKRIFSFNE..YRRLH
 1123- 1157 (58.31/35.14)	NVED.STC.....HYNIATFYMLL.AGRSCFSINAlvHQLLH
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      47.75|      10|      49|    1183|    1192|       6
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 1183- 1192 (16.82/10.16)	ALLVLANVIC
 1225- 1234 (17.90/11.33)	HLHDVGDEVC
 1235- 1241 (13.03/ 6.06)	ALLV...TIC
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     136.31|      37|      40|    1727|    1766|      11
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  431-  468 (66.86/44.69)	PTMLHQLCGSPLDHLPCPFESLPLPPGHgTERLQEFVQ
 1728- 1764 (69.45/51.47)	PWSWSMLQAVKLDRLPVPVQRYIQRLVH.HSHYNEFVR
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      74.29|      24|      40|    1785|    1811|      12
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 1785- 1811 (36.62/31.93)	MDVSetpATLHHVSSNAV....TSTTTSASS
 1823- 1850 (37.68/23.54)	MDVS...ATLGSVTQSRTmgyqSSATPSCTS
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.57|      21|      40|    1332|    1352|      13
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 1332- 1352 (35.34/23.86)	IVRELTI..CNG.NSKKSLI..DKLL
 1370- 1395 (23.23/12.87)	MIREISPegCTSkHAQQSAIaaDALL
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP00249 with Med12 domain of Kingdom Metazoa
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