<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP00248

Description Uncharacterized protein
SequenceMERCSYFLKKKNRKCRMLVKNGQKYCGEHAICDELNEDRVVCPNDPKHTVNKSQLQKHLSSRCNSRLPEERWIVENFNLIGSPNEAEPWYHPTDKELLRMGKIVERIYDQIANDIADSFLKNNYVENYAADHSKLDKKHIWQISSIIEHLSVNDLLNNNKCWCLIDFGAGKAQLSYWMAKIAPKCRFLLVEKMGSRNKFDNKIHKEVDKIFLERLRCSVEHLDLSKIDLIQNANNVAAVCKHFCGSATDFGIRCLMNGVKNNLNICGFALAPCCHHRITYREYIGHAFLESHGICSSNEFAALRHISTWAVCGFLSQENCGGDVSVSSHSQELKNADQQKTVLEFVSLNSAEKELLGQKAKAILEFGRIMELRKFGYDVSLCSGLNSVPGPETSEEQKKRFEIECEFVQALANPHYLNFLAQRGYFKEPFFINYLKYLLYWKRPEYARALKYPQCLHFLEAVQSSAFREAVTCTANAKFIEEQQLLQWQYYTRKRQRLHMYTTEHDDDEQEWRQQPSQRQKERELKFVEALEGTCKRMLQYKLHKEKSDISRFAKEESSTMKALNELRSKGVKVELGMPYEMWDSPSVEIVTLKQNCETLLEHYEDDLEQWYHIQDRPLLEEYLCKKRILKRTERGCMDTANNLEL
Length646
PositionMiddle
OrganismOnchocerca volvulus
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Chromadorea> Rhabditida> Spirurina> Spiruromorpha> Filarioidea> Onchocercidae> Onchocerca.
Aromaticity0.10
Grand average of hydropathy-0.591
Instability index46.21
Isoelectric point7.87
Molecular weight75512.52
Publications









Function






Annotated function

tRNA methylase which 2'-O-methylates cytidine(4) in tRNA(Pro)
and tRNA(Gly)(GCC), and adenosine(4) in tRNA(His).



GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
metal ion binding	GO:0046872	IEA:UniProtKB-UniRule
transcription coregulator activity	GO:0003712	IEA:InterPro
tRNA 2'-O-methyltransferase activity	GO:0106050	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription, DNA-templated	GO:0006355	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP00248
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      93.17|      23|      38|     406|     428|       1
---------------------------------------------------------------------------
  406-  428 (42.13/27.80)	EFVQALANPHYLNFL..AQRGYFKE
  430-  446 (25.71/14.02)	FFINYL...KYLLYW..KRPEY...
  448-  469 (25.34/13.71)	...RALKYPQCLHFLeaVQSSAFRE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     231.64|      85|      90|      47|     136|       2
---------------------------------------------------------------------------
   47-   98 (60.88/45.82)	.......................................KHTVNKSQLQKHLSsrCNSRLPEER.WIVENFNliGSPNEAEPWY...HPTDKELL
   99-  189 (131.67/88.08)	RMGKiVERIYDQIANDIADSFLKNNYVENYAADHSKLDkKHIWQISSIIEHLS..VNDLLNNNKcWCLIDFG..AGKAQLSYWMakiAPKCRFLL
  192-  228 (39.08/18.60)	KMGS.RNKFDNKIHKEVDKIFLERLRCSVEHLDLSKID.........................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.48|      21|      23|     324|     345|       3
---------------------------------------------------------------------------
  324-  345 (30.77/21.21)	VSVSSHSQELKnADQQKTVLEF
  346-  366 (33.71/18.74)	VSLNSAEKELL.GQKAKAILEF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.17|      11|      23|     487|     497|       4
---------------------------------------------------------------------------
  487-  497 (22.40/13.44)	QW..QYYTRKRQR
  511-  523 (16.77/ 8.36)	EWrqQPSQRQKER
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      94.81|      29|     238|       4|      32|       5
---------------------------------------------------------------------------
    4-   32 (57.96/35.21)	CSYFLKKKNR...KCRM.LVKNGQKYCG.......................EHAIC
  240-  295 (36.85/19.87)	CKHFCGSATDfgiRCLMnGVKNNLNICGfalapcchhrityreyighafleSHGIC
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP00248 with Med31 domain of Kingdom Metazoa
Unable to open file!