<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP00248

Description Uncharacterized protein
SequenceMERCSYFLKKKNRKCRMLVKNGQKYCGEHAICDELNEDRVVCPNDPKHTVNKSQLQKHLSSRCNSRLPEERWIVENFNLIGSPNEAEPWYHPTDKELLRMGKIVERIYDQIANDIADSFLKNNYVENYAADHSKLDKKHIWQISSIIEHLSVNDLLNNNKCWCLIDFGAGKAQLSYWMAKIAPKCRFLLVEKMGSRNKFDNKIHKEVDKIFLERLRCSVEHLDLSKIDLIQNANNVAAVCKHFCGSATDFGIRCLMNGVKNNLNICGFALAPCCHHRITYREYIGHAFLESHGICSSNEFAALRHISTWAVCGFLSQENCGGDVSVSSHSQELKNADQQKTVLEFVSLNSAEKELLGQKAKAILEFGRIMELRKFGYDVSLCSGLNSVPGPETSEEQKKRFEIECEFVQALANPHYLNFLAQRGYFKEPFFINYLKYLLYWKRPEYARALKYPQCLHFLEAVQSSAFREAVTCTANAKFIEEQQLLQWQYYTRKRQRLHMYTTEHDDDEQEWRQQPSQRQKERELKFVEALEGTCKRMLQYKLHKEKSDISRFAKEESSTMKALNELRSKGVKVELGMPYEMWDSPSVEIVTLKQNCETLLEHYEDDLEQWYHIQDRPLLEEYLCKKRILKRTERGCMDTANNLEL
Length646
PositionMiddle
OrganismOnchocerca volvulus
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Chromadorea> Rhabditida> Spirurina> Spiruromorpha> Filarioidea> Onchocercidae> Onchocerca.
Aromaticity0.10
Grand average of hydropathy-0.591
Instability index46.21
Isoelectric point7.87
Molecular weight75512.52
Publications









Function






Annotated function

tRNA methylase which 2'-O-methylates cytidine(4) in tRNA(Pro)
and tRNA(Gly)(GCC), and adenosine(4) in tRNA(His).



ECO:0000256	RuleBase:RU367103

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
metal ion binding	GO:0046872	IEA:UniProtKB-UniRule
transcription coregulator activity	GO:0003712	IEA:InterPro
tRNA 2'-O-methyltransferase activity	GO:0106050	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription, DNA-templated	GO:0006355	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP00248
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      93.17|      23|      38|     406|     428|       1
---------------------------------------------------------------------------
  406-  428 (42.13/27.80)	EFVQALANPHYLNFL..AQRGYFKE
  430-  446 (25.71/14.02)	FFINYL...KYLLYW..KRPEY...
  448-  469 (25.34/13.71)	...RALKYPQCLHFLeaVQSSAFRE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     231.64|      85|      90|      47|     136|       2
---------------------------------------------------------------------------
   47-   98 (60.88/45.82)	.......................................KHTVNKSQLQKHLSsrCNSRLPEER.WIVENFNliGSPNEAEPWY...HPTDKELL
   99-  189 (131.67/88.08)	RMGKiVERIYDQIANDIADSFLKNNYVENYAADHSKLDkKHIWQISSIIEHLS..VNDLLNNNKcWCLIDFG..AGKAQLSYWMakiAPKCRFLL
  192-  228 (39.08/18.60)	KMGS.RNKFDNKIHKEVDKIFLERLRCSVEHLDLSKID.........................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.48|      21|      23|     324|     345|       3
---------------------------------------------------------------------------
  324-  345 (30.77/21.21)	VSVSSHSQELKnADQQKTVLEF
  346-  366 (33.71/18.74)	VSLNSAEKELL.GQKAKAILEF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.17|      11|      23|     487|     497|       4
---------------------------------------------------------------------------
  487-  497 (22.40/13.44)	QW..QYYTRKRQR
  511-  523 (16.77/ 8.36)	EWrqQPSQRQKER
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      94.81|      29|     238|       4|      32|       5
---------------------------------------------------------------------------
    4-   32 (57.96/35.21)	CSYFLKKKNR...KCRM.LVKNGQKYCG.......................EHAIC
  240-  295 (36.85/19.87)	CKHFCGSATDfgiRCLMnGVKNNLNICGfalapcchhrityreyighafleSHGIC
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP00248 with Med31 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




NANANA









Molecular Recognition Features






MoRF SequenceStartStop




1) RCSYFL
3
8