<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP00246

Description Uncharacterized protein
SequenceMNISDWAKPEVVQLLEQYIQEPARSIEELQKLIQQIAGKNVTVSKLRHHLQQFQKETVVYKQHSKDVVFNENEKSTTEIKQCNSRRTAAENRVSVEVIPTDSTNFEQGIQMAREISINKQEKISNSREQIDHVPDNAKAASIRTRTLRKKLRVSTWRKKELQMLRSSRSRRRKKMKNGSSTTTIIDRGKNLKATTDDKSVKQKAEEQEMNSTIKAAGTIVPSTELTVLISSKPRVILRRTTLVRTRCTVLATKPTIPISVVTSYSQQIPDWNVHENDDVTELTIPNSNTDAVTSYSQGIFGGNVRGNHGNDDITLLWQPVTYSSIGLESNPTGVYIDSSYSSGSEMQGNLSIQQFQSLTTHLDHCLNALRLLRNEVTSVHRRIMENNWESDPADSEKTLEEKLDFINQIYDNLESHAKQLPLSTPMTVQMERLSRFLHDGQIDPHTSELYDKALEASTWMETNNQLLQMYAEFLRTVVGNRRRSIMTDRPISYSNYGPNSSPQSIFEQTLTVVLKDPNIKKIGLVGRYLEKSTLSALVEFKFGQVIDKQYVCLLKMLMVVNSGLPEFVQMIAPHEEWSYLDVGSGQVDIHKESRYLVYRKMSVQANIHLMQTIMPCIDIRNAHTLSYVLNLFAKFSGVFDIKCRVCKKIMKDYLPPLMFDLRCPKNALHESFIVFQRIAKIDGAEYVTVDSSALHCPVCFCIFASAPLILKCGHSFCRNCVKKLVENSYSEHDGIFECPMCRQVTSCETYFTKNYLADALLQSVCGISQDEKGSCMDANLRLSFRLISRKFLEEQEKNNILRKKYEEERLRSRRYLIFLIMESALLISSAFLYKLLFF
Length838
PositionTail
OrganismOnchocerca volvulus
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Chromadorea> Rhabditida> Spirurina> Spiruromorpha> Filarioidea> Onchocercidae> Onchocerca.
Aromaticity0.07
Grand average of hydropathy-0.395
Instability index47.39
Isoelectric point8.83
Molecular weight96005.02
Publications









Function






Annotated function


GO - Cellular Component
integral component of membrane	GO:0016021	IEA:UniProtKB-KW
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
metal ion binding	GO:0046872	IEA:UniProtKB-KW

GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP00246
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     124.75|      33|      33|     248|     280|       1
---------------------------------------------------------------------------
  248-  273 (40.19/27.64)	................TV.LATKPTIPISVVTSYS...........QQIPDWNV
  274-  304 (48.78/35.25)	HENDDVT.......elTI.....PNSNTDAVTSYS...........QGIFGGNV
  308-  360 (35.78/23.74)	HGNDDITllwqpvtysSIgLESNPT.GVYIDSSYSsgsemqgnlsiQQFQSLTT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     119.31|      28|     101|     613|     640|       3
---------------------------------------------------------------------------
  613-  640 (49.57/35.06)	IMP..CID..IR...NA.HTLSYVLNLFAKFSG....VFD
  653-  690 (27.50/16.13)	YLPplMFD..LRcpkNAlHESFIVFQRIAKIDGaeyvTVD
  709-  737 (42.25/28.78)	ILK..CGHsfCR...NC..VKKLVENSYSEHDG....IFE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     133.68|      34|      34|     418|     451|       4
---------------------------------------------------------------------------
  418-  451 (58.95/39.61)	KQLPLSTPMTV..QMERL.SRFLHDGQIDPHTSELYD
  452-  488 (43.67/27.43)	KALEASTWMETnnQLLQMyAEFLRTVVGNRRRSIMTD
  495-  519 (31.06/17.39)	NYGPNSSPQSI..FEQTL.TVVLKDPNI.........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.97|      14|      23|     141|     155|       6
---------------------------------------------------------------------------
  141-  155 (19.79/15.98)	SIRTRTlRKKLR..VST
  166-  181 (20.19/11.08)	SSRSRR.RKKMKngSST
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP00246 with Med27 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GIQMAREISINKQEKISNSREQIDHVPDNAKAASIRT
2) KKELQMLRSSRSRRRKKMKNGSSTTTIIDRGKNLKATTDDKSVKQKAEEQEMNSTIKAA
108
158
144
216










Molecular Recognition Features






MoRF SequenceStartStop




NANANA