<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP00241
Description |
Mediator of RNA polymerase II transcription subunit 14 |
Sequence | MDDEEYMKPMLPTVPEKCGPPVIPLGHLIEFAVQQIFHELTVLSELLPKKLDSDRKISIVQFAHSTRVLFIKLLAVVKWVKSSKKFESCASICYFLDQQSQYFVDTADRLVQLAREELVFARLPTFQVALAVDVLTAGTFPRLPLCIKNRFIPDPPITPREEACVLARLNQVIQYRLSSYGTKLSPRISKTVIRNGMVTMTVNGEFEVSLTLLGERPTTKWTLLNIRILVEDYEIGFGTKLVHPLQVNMLHNVLQLRMDKSLEPFQEVYSLLHSFAQMLQLDVLFCQATQVLSGDMCQYAVIERYDRNMGILILAYWLKRTYNRYTSQYRIKIFIDKENENNGLRVRHFPVGKGLPYIDDRSGRLSINRLLSETVGVRCRERLLRIRERLGLLKPPVIVSLTGRAAPTLTYPLLGAQSHVDEMLVLSINDFSGNVIAIVRALGPSLELRELEQLIDDRVPLQTITDKMGRLRILLMLERYRKAVAPLPVRIVPENVFCTRLSSLPELPPDRIYLQFIKEEMYYLIVSFTPNEQTGVNIDMYLLSNIERKLNMVRLHPSQLLTTLPESSFSNARNEDDLEPPAKRRRWLGDRRLLTSAVATLDDRLAFMRICEELDRRKVKYKPLTVEPTVGGLILHITDFSEAVPSGSDDFFSSVINCCLRLDTRTRVIWPFECTLINTPLVADFYEPIMCVDYESAKTKTTVMEIHGSGGVSSPNTSESVSTHMIDRLIVFAHMFDPVKEFAAAYYSHYNKYCNIVAFTYHKLVLAYGSNRNMLMMLSWRTQKAPNNKQYFYLTFGIGPNRPTTTVDLTNSETYNFHMLWNPHVLLASRLQERFNKRRSLIDLVQYLIDSVAPLFALHSFTRIRLQSLRAFCQMMCYDASLALSLQVTIAIVDEYRIRLIYGHMHLEFLLLGNSRIGLRDCSLGSACVFRLLQFCSNFLNSELRNMNEEKSPSAFGWTGSGSGPGSLPCHQMVRSPASRIVSSPMSHMSLSVPPIDSFGSSLRYSSDGRSKTPILLDHDSLLCMTSVDESGSCPLDQYLFALAYLSKLGPALEGYRREHRGSGAHPIIQFRQLITTPESVRLSVLGAAPPNLKHEPFLVNMNIYLDEETMSLKMKLDFDGEDIPADSDIRTAELYFIRFVARLGNEIAVVAFANACRLAAPGAFSAIARIMSMQMNWTEDTPWRPSIQLVMWSQEGSVPRARISPGIVIDQTNISVLILLCLRPARHNPSEKNADASKHLIPLIYNTQTNTVARRSSGADDDASNATTVLSNVSEQYSLTNEPALWPAIYSLAHNFAIQR |
Length | 1301 |
Position | Tail |
Organism | Onchocerca volvulus |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Ecdysozoa> Nematoda> Chromadorea> Rhabditida>
Spirurina> Spiruromorpha> Filarioidea> Onchocercidae> Onchocerca.
|
Aromaticity | 0.09 |
Grand average of hydropathy | -0.055 |
Instability index | 45.58 |
Isoelectric point | 8.46 |
Molecular weight | 147619.35 |
Publications | |
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU365082
|
GO - Cellular Component | mediator complex GO:0016592 IEA:UniProtKB-UniRule
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:UniProtKB-UniRule
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP00241
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
3| 70.51| 16| 248| 218| 233| 1
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218- 233 (26.91/18.67) TTKWTLLNIRILVEDY
465- 480 (25.42/17.15) TDKMGRLRILLMLERY
481- 495 (18.18/ 9.78) RKAVAPLPVRIVPEN.
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 165.50| 52| 393| 743| 849| 2
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522- 578 (75.57/29.17) YYLIVSFTPNEQTgVNIDmylLSNIE.RKLNMVrLHPSQLLTTLPESSFSNARNEDDL
792- 844 (89.93/44.36) FYLTFGIGPNRPT.TTVD...LTNSEtYNFHML.WNPHVLLASRLQERFNKRRSLIDL
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 151.04| 53| 605| 255| 447| 4
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255- 333 (60.27/63.56) QLRMDkSLEPfqeVYSlLHSFAQmLQLDVL..FCQAtqvlsgdMCqyavierYDRNmgiliLAYWLKRTYNrYTSQYRIKI
846- 900 (90.77/118.51) QYLID.SVAP...LFA.LHSFTR.IRLQSLraFCQM.......MC.......YDAS.....LALSLQVTIA.IVDEYRIRL
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 40.98| 11| 15| 141| 151| 5
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141- 151 (21.53/13.14) PRLPLCIKNRF
159- 169 (19.45/11.13) PREEACVLARL
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 114.13| 39| 605| 400| 447| 6
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400- 447 (60.77/75.06) SLTGRA.AP.TLTYPLLGAQSHVDEmlvlsindfSGN........VIAIVRALGPSLE
1006- 1054 (53.35/43.51) SSDGRSkTPiLLDHDSLLCMTSVDE.........SGScpldqylfALAYLSKLGPALE
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