<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP00237

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMSTNGGSLEDCHTNVFALTELNGLKWKCLTTPLSQRTWTSLEQDPVLSAYAKCLQAGILCAWRRQPPQPTSTLAAMQLPDYRIDVVKELWIFWYSHEEPDCLTEYTSHLACAEDGQGNWSVPGIQYETRTLFFKALHNLIERNMLKNGYIRIGKYFTRPYEVPSSDRIHCSPNYVNGISFNFFVHGENIVCATVCVQRQPTLFRLSRRHLDLGKKQSVILGPWSMRAVLLPEQPRIVDSTTPILQQQPLTPECDSFTNSSTAYASSYREPLSSVAHQVNPVPSSSVESDTVNSSNHDSAGTISKAAVDKLWSEWLQFFCLIVNVERNLSSADTVGYIGYTENASSIKSSLPKMVLVDVDGVHMWYPSSLIVVQASDDLLMRQNEKTTNDSSSDFFNSRTSSRSFTPRTPPTTRLRSSPSFRKRKKRLSECDVEASAEWHNAMYGTMVNGARAAQRFFEESFIAPANSRRKENSESPSSSGLGLLLSSATSDDDCRWNSTDGMRRKDREEGCGCHHCRLQQPSDTAAVSNLSSQYTCLSQEPSQSCCTPINFPSNSSSLEARKEEPILFHRRSSLCTRSPSPPRSPLWEKKILATSSEAVDGEHSLDWIRENYFRNSKSNSRSGRSDPLNEEKHVCPKTPDASAITESPERRRVQRNSVQMFGKIGSCKPVYQNLSPTSRPRSPACDTSQTESLSRMQSKDCLSSDFVPLSARKHEPTIAEQQPNLINSLRLKKEEKSKGRKRKLNEKLEWSGIEALDVSFLTAKVGEDDEDGDDINFICSNKFKLHECKLEIKDEAIESSSRESAASQSGSLNAVSLSQAQDGLRNLPVFSQIGSVLSSNTSVNLTPSIFTSDCDTQPLFVDDCNLSTIAMIERRSPVDTVVTDSVHLSPPASNERVEPTQILGGTVANVIARVGGPPSVGDYMIYPTPPSSQQFSPQNTLIQANPTSILYPPTISYMAAAVNLCHNHPPVQPSGIVSETDITMETVPNVKRELDNDDGRLLGKLHYSIVEKPVYGKFMKLEMALSGKFAGNILAKEFLSLEAKECRILEGVYADQLKLIKTAVAAREKRKKVGRAPDYLFMRERLRNLTPHSSFAAVRYYRMPYNNGHMLSSHSLPTFQMLPYGMAMNGMPNFVTNGPPFAGTSYNGGNSMMSMMMGNSCIPPSSTAVMQSMPGSSRMNFVHMNQQMSMAHLRPLARIPYASSQPGAPQHSPFMGQSAQFCSPPGMMNATNPIYSFPGGTMCSMNTDPMQSSHILSGIHSTTPSQSFSANSMHGAGPPNGQFCMQQSQQPFQQLNHFVNNANFNGQMGMGAINPSQQNIYQQQMMFRCNMGGNLTPQHAIHLSDSYGTDSQIRSNQAPVEPPPSFSQAVNHQYPPVHNVQAGSVMYSQSSHIMCPNALIAQAQNANMMYGPRTPQNSMITVPSSIGSPNNGGLFGNRLMNMPAVMETTAVPPSRMRYPEGKSLVLAVLLQDTVLDLHYDSVFDACPICSCNGSIRAKELGVYITPPEVLRQPPAQQQLIVSKPTSGFYNNTSNSCNCGFSAVRHRYLSMKAGLFAEDAKEATDISETQNQPAIPHTIWFDSMSGRDMNFIALLREQTLVRDLGGLLDQVTLLSLQCERALQTERIGSDSSKHCEYIISEVDQRELPLVFQAACEVACMEMNCRRPPHDVRSVLLHDWGIQVSNEMREPRESECMALLQEIGPILEESLRIARSSPLFGSNNIVEGPLTWRFFDRKALKAAGGMEDDSGPEAVPNIVVASEKDAVIASPQIIRLWEKMSLEPYDQPKDVLYIGVVPDNLICIEKTKKYLMDLSRMYEQCRFGRHIPFTREVLRDGLLRVPTRYPATNPGECDNFLNQVERHIGDNKSLITRLKVYMQYFENEMARILINNDDIFSREKYRAALAESQMHSMSHISASYQCAGYTVSNSDHMPPSSAPGNIIIGQSTEASQNVSNASGPSSAGPASSSVGESLTSDGPIGDGSAQNINSFSSFMVEQLIADGTIAEDEPGTLPHVIVIYLVNPFLLGAEENPLVARVVTVALMRAFNALLYRLNNKCRPQLQLEMITLQSIFDYCGICADFLKDERGRLNGRLEKSQNERMSSSDSLKSVAFSVYTHSRVVLPDIVRGILPKSMTRFGPASAMVDLLNDLERKEPIYYKIPSKPFILAPPSLVMQRPNCDLMQINTDEAVLFVSYCLIGNDWLAATVTDHQGHSLDNCLINLRLKPDHKRVNMKYKQSTQIRDSLYRLWSYILGTLANGTRNWRLVIGRVGRIGHGEFKFWTQILSKSYLKQIGTRMKHVCRACHVMPGTSEVPGVLSACLVSLEPEAHLRVFPSSFQHDDRFLKNSRYRTLTTPDDTSCTHILVFPTSPELNLDHQGGNGVAELEEDDFSNLLTEEIGEEFSELIGNGEDLMTNGTGPPQQSTNFRLGGNTGIPSEYADVSIENQPLATGYYISTAPASDLPEWFWSACPSAKRRNPVHLKSSLHLNTPNVQQGDDISSFGKGTEACHHQLDSQATADVLRYVLEMYNALSWLNIDLISGERRSCLPVHIQALMWLCNAVNRFIN
Length2565
PositionMiddle
OrganismOnchocerca volvulus
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Chromadorea> Rhabditida> Spirurina> Spiruromorpha> Filarioidea> Onchocercidae> Onchocerca.
Aromaticity0.07
Grand average of hydropathy-0.384
Instability index57.76
Isoelectric point6.31
Molecular weight284830.39
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP00237
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     747.08|     241|     271|     246|     516|       1
---------------------------------------------------------------------------
  246-  516 (378.15/280.89)	QQPltPECDSFTNSSTAYASSYREPLSSVAHQVN.PVPSSSVES...DTVNSSNHDSAGTISKA.AVDKLW.SEWLQFFCLIVNVERNLssaDtvgYI..GYTENASSIKSSLPKMVLVDVDGVHMWYPSSLIVVQASDDLLMRQNekttndsSSDFFNSRTSSRSFTPRTPPTTRLRSSPSFRKRKKRLS.....EC...D.VEASAEWHNAMYG....TMVNGARAAQrffEESfiapANSRRKENSESPSSSGLGLL....LSSATSDDDcrwnsTDGmrrKDREEGCG....CHHC
  519-  788 (368.93/213.42)	QQP..SDTAAVSNLSSQYTCLSQEPSQSCCTPINfPSNSSSLEArkeEPILFHRRSSLCTRSPSpPRSPLWeKKILATSSEAVDGEHSL...D...WIreNYFRNSKSNSRSGRSDPLNEEKHVCPKTPDASAITESPERRRVQRN.......SVQMFGKIGSCKPVYQNLSPTSRPRSPACDTSQTESLSrmqskDClssDfVPLSARKHEPTIAeqqpNLINSLRLKK...EEK....SKGRKRKLNEKLEWSGIEALdvsfLTAKVGEDD.....EDG...DDINFICSnkfkLHEC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     483.97|     101|    1190|    1164|    1264|       2
---------------------------------------------------------------------------
  930- 1052 (110.09/53.35)	P........SSQQFSPQNTLIQANPTSILYPPTISYMAA....AV......NLC.HNHPPVQPSGIV....S...............ETDITME.......................tvpnvkreldnddgrllgklhysivekP.........................VYGKFMKlemA..LSGKFAGN.ILAKEFL....SLeaKEC..RILEGV
 1053- 1199 (112.22/54.54)	.YAdqlkliKTAVAAREKRKKVGRAPDYLFMRERLRNLT....PHSSFAAVRYYRM...PYNNGHML....S...............S.HS.LP....tfqmlpygmamngmpnfvtngppfagtsynggnsmmsmmmgnscipP.........................SSTAVMQ...S..MPGSSRMNFVHMNQQM....SM..AHL..RPLARI
 1200- 1341 (122.38/60.20)	PYA......SSQPGAPQHSPFMGQSAQFCSPPGMMNATN....PIYSFPGGTMCSMNTDPMQSSHIL....S...............GIHSTTPsqsfsansmhgagppngqfcmqqsqqpfqqlnhfvnnanfngqmgmgainP.........................SQQNIYQ...................QQMmfrcNM.gGNL..TPQHAI
 1342- 1477 (90.61/42.50)	.HL......SDSYGT..DSQIRSNQAPVEPPPSFSQAVNhqypPVHNVQAGSV..MYS...QSSHIM....CpnaliaqaqnanmmyG..PRTP...................................................qnsmitvpssigspnngglfgnrlmNMPAVME...TtaVP.PSRMRYPE.GKSL....VL..AVLlqDTVLDL
 1478- 1532 (48.68/19.14)	HYD......SVFDACP...........ICSCNGSIRAKE...lGVYITPPEV...LRQPPAQQQLIVskptS...............GFYNNT.............................................................................................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     268.09|      83|     817|     810|     899|       3
---------------------------------------------------------------------------
  810-  899 (125.89/114.22)	GSLNAVSLSQAQdGLRNLPVfSQIGsvlsSNTSVNLTPSIFTSDCDTQPL.FVDDCNLSTIAMIERRSPVDtVVTDSVH.LSPPASNERVEP
 1605- 1689 (142.20/102.49)	GLLDQVTLLSLQ.CERALQT.ERIG....SDSSKHCEYIISEVDQRELPLvFQAACEVACMEMNCRRPPHD.VRSVLLHdWGIQVSNEMREP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     106.03|      30|     478|    1806|    1837|       6
---------------------------------------------------------------------------
 1806- 1837 (52.76/41.77)	KKYLMDL.SRMYEQCRFGRHIPFTREVlrDGLL
 2286- 2316 (53.27/35.46)	KSYLKQIgTRMKHVCRACHVMPGTSEV..PGVL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     101.05|      29|    2219|     177|     205|       9
---------------------------------------------------------------------------
  177-  205 (53.38/29.95)	GISFNFFV.HGENIVCATVCVQRQPTLFRL
 2398- 2427 (47.68/25.95)	GEEFSELIgNGEDLMTNGTGPPQQSTNFRL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.68|      17|    1994|     159|     175|      10
---------------------------------------------------------------------------
  159-  175 (34.74/20.60)	P..YEVPSSDRIHCSPNYV
 2154- 2172 (27.94/14.86)	PiyYKIPSKPFILAPPSLV
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP00237 with Med13 domain of Kingdom Metazoa
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