<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP00232

Description Mediator of RNA polymerase II transcription subunit
SequenceMEKMSSENQIANIVNDILKVEAIEEAFSCVLVHHPNNDTEKITTWQNELKSVLTGLTKEQQEAAVRQFLSMAAAMTNHRRLQLLLSLLENLVHSNFLPARLVCECILSCDKLQYQLEDFWIECFVLIRRIIGAVDYKGVREIMKGCKEKAQTIPARLDASVQPQLKALENVIEYIFDRNACLLPGYFIVNEIQKAYPDGKNWPHWRLAKLLSSFVESFRNTAQMVSIVGHSKMLPVVEHTGYADHLINPWLLDPTTLKFSLKGNLPYNPDLLKPQTELLRYVLEQPYSRDMVCSMLGLQKQHKQRCIVLEEQLVELVILAMERSENETLPVEGTDGTVANHWVWLHLSSQLIYFILFQFACFPSIVMAIHDKLAGRELRKGRDHLMWVLLQFISGSIQRNPLSNFLPVLKLYDLLYPEKEPLPVPDYTQALCTHQMAITCIWIHLLKKAQSEHSNIHRPIPHTLKVHHEFLQHLVMPNTSLCMGSDYRIALLCNAYSTNQEYFSRPMAALVDTILGTQKSQQQQPLQTLQNNAALANGPTTPLSMSILDSLTVHSKMSLIHSIVTHVIKLAQSKSNMALAPALVETYSRLLVYTEIESLGIKGFISQLLPTVFKSHAWGTLYTLLEMFSYRMHHIQPHYRVQLLSHLHSLAAVPQTNQTQLHLCVESTALRLITGLGSAEVQPQLSRFLSEPKTLVSAESEELNRVLVLTLARSMHVTGTGADSLSGTWCKELLHTIMQNTPHSWANHTLQCFPPVLSEFFQQNSVAKENKQQIKKAVEEEYRNWASMNNENDIIAHFSVPGTPPLFLCLVWKMIFERDCISPIAYKILERIGARALSAHLRKFCDYLVFEFANSAGGQHVNKCVDTINDMIWKYNIVTIDRLVLCLALRTQEGSEAQVCFFIIQLLLLKAVEFRNRVQEFVKENSPEHWKQSNWHEKHLAFHRKFPEKFAPEGIMEQTTGGPSQYQSLPVYFGNVCLRFLPVFDIVVHRYLEIPPVIKSLETLLEHLGCLYKFHDRPVTYLYNTLHYYERKLRDRPSLKRRLVSAVLGSLREIRAPGWALSEAYQIYMTRSADNAVNWIPELDYYVRLVQRMVETMSGTAHFPATDWRFNEFPNPAAHALYVTCVELMAVPVTPQLVANSLLDVVAKGYTVIPSDEIHLWINCVGLLLAALPECYWSALHDRLVETINSPGLVNWQYNNLTPFQMFNFDITHNSLLENKYSYMLALAHSVWHHAGVGQITTMPQFIKEKLQPFVTSEEQLIYACHLIGPTLARFNAERPHCVVELAVCLYEMLERVDHTQTTLKYMDPVCDLLYHIKYMFVGDMMKNEVECIVRRLRHPLQMRLRFIAHINVDEIHTS
Length1359
PositionTail
OrganismOoceraea biroi (Clonal raider ant) (Cerapachys biroi)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Hymenoptera> Apocrita> Aculeata> Formicoidea> Formicidae> Dorylinae> Ooceraea.
Aromaticity0.09
Grand average of hydropathy-0.050
Instability index45.18
Isoelectric point6.79
Molecular weight156021.33
Publications
PubMed=24508170
PubMed=30249741

Function

Annotated function 
GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP00232
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     683.19|     226|     277|     754|    1030|       1
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  754- 1030 (345.44/308.61)	PPVLSEFFqqnSVAKENKQQIKK...AVEEEYRNWASMNNENdiiahfSVPGTPPL..FLCLVWKMIferDCISPIAykilerigaralsaHLrKFCDYLVFEFANSAGGQHVNKCVDTIN.............DMIWK.YNIVTIDRLVL...CLALRTQEGSEaqvCFF.IIQLLLLKAVEFRNRVqefvkenspehwkqsNWHEKHLAFHRKFPEKFAPEGIME.QTTGGPSQYQSLPVYFGNVCLRFLPVFdivVHRYLEipPVIKSLETLLE..HL.G...................CLYKFHDRpVTYLYNTLHYYE
 1037- 1308 (337.75/205.48)	PSLKRRLV...SAVLGSLREIRApgwALSEAYQIYMTRSADN......AVNWIPELdyYVRLVQRMV...ETMSGTA..............HF.PATDWRFNEFPNPAAHALYVTCVELMAvpvtpqlvansllDVVAKgYTVIPSDEIHLwinCVGLLLAALPE...CYWsALHDRLVETINSPGLV...............NWQYNNLTPFQMFNFDITHNSLLEnKYSYMLALAHSVWHHAGVGQITTMPQF...IKEKLQ..PFVTSEEQLIYacHLiGptlarfnaerphcvvelavCLYEMLER.VDHTQTTLKYMD
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.15|      16|     582|     683|     703|       2
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  683-  703 (23.18/22.54)	PQLSRFLSE.PKTLVsaeseEL
 1270- 1286 (26.98/14.38)	PTLARFNAErPHCVV.....EL
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     315.45|      67|     219|     230|     305|       3
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  230-  294 (107.67/60.40)	..........................HSKMLPVVEHTGYADHLINPWLLDPTTLKFSLKGNLPYNP...........DLLKPQTELLRYVLEQPYSRDMVCS
  370-  433 (73.71/38.21)	..........................HDKLAGRELRKGR.DHLM..WVL....LQF.ISGSIQRNPlsnflpvlklyDLLYPEKE....PLPVPDYTQALCT
  434-  513 (87.33/45.55)	HQ.......maitciwihllkkaqseHSNIHRPIPHTLKVHHEFLQHLVMPNT.SLCMGSD..YRI...........ALLCNAYSTNQEYFSRPMA.ALVDT
  519-  593 (46.74/34.56)	KSqqqqplqtlqnnaalangpttplsMSILDSLTVHSKMS..LIHSIVTHVIKLAQS.KSNMALAP...........ALVETYSRLLVY.............
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      33.41|       9|     432|     203|     212|       5
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  203-  212 (14.94/10.56)	PHWRLaKLLS
  637-  645 (18.47/ 8.60)	PHYRV.QLLS
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      78.65|      25|     388|     318|     346|       7
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  318-  346 (42.04/38.35)	ILAMERSenetLPVEGTDG.TVANHWV..WLH
  708-  735 (36.60/23.12)	VLTLARS....MHVTGTGAdSLSGTWCkeLLH
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP00232 with Med23 domain of Kingdom Metazoa
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