<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP00230

Description Mediator of RNA polymerase II transcription subunit 15
SequenceMAQDDSSWKTQSFRQSVVAKIDEAVQVCRMPTTRSGIEMENHVFRKAKSKEEYLGFVARLILHVREMNSKKDAADNAPGAAGSNNPGMQDPIGALQTLARQGTGNNQMMGMGGPGPNHQGIIPQPTANTATNLLQSLNQRPGQPMNMPGMQNKMPGMNMMPAQAGGPMGHMGPIQTMQNNPMLTQMNQMGQGNIPQQMNQMVPGQMGQLAAGQMQPNMQSQMQNQLPNQINNQIGGPMGGIQASMPQQMNQIGPGQLGPGQMQQQLNHIQRKPAEMMNAGFPGPRNVTPNQFLRQSPSPSAPSPAGLGAPSSNQMVASPALVPSPSPQHAIMTGPSRSVNSVGMAPSPSSSLNTPGGVGATPSPQQEDQAYRDKVRQLSKYIEPLRRMIAKMSSEGNVDKLSKMKKLLEILSTPSKRMPLDTLLKCEVVLEKLDFKRGDGSVGPPVTTLKEHQIFSPLLEAVSAHLQSPVINHTLQRTFGPCLDALFGPEIKSLPAPLKKHKIEEPSSEIPDVLQGEIARLDQRFKVSLDPAQQSGSKCIQLICWLDDRHLPCVPPISVTVPADYPSTPPRCVMAPHEYEATTFLCAVQKALNARIAKLPRRFSLSQLLDTWEMSVRQASAPREMLVTASTVLMGL
Length636
PositionTail
OrganismOoceraea biroi (Clonal raider ant) (Cerapachys biroi)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Hymenoptera> Apocrita> Aculeata> Formicoidea> Formicidae> Dorylinae> Ooceraea.
Aromaticity0.03
Grand average of hydropathy-0.459
Instability index58.38
Isoelectric point9.36
Molecular weight68869.70
Publications
PubMed=24508170
PubMed=30249741

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364148
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP00230
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     133.90|      23|      25|     212|     234|       1
---------------------------------------------------------------------------
  168-  188 (37.64/13.68)	M..GHMGP.IQTMQNNPMLTQM.NQ
  189-  209 (27.90/ 8.03)	MgqG....NIPQQMNQMVPGQMGQL
  210-  233 (41.39/15.86)	A.aGQMQPNMQSQMQNQLPNQINNQ
  279-  295 (26.98/ 7.49)	A..GF..PGPR....NVTPNQFLRQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     111.10|      25|      25|     302|     326|       2
---------------------------------------------------------------------------
  138-  155 (33.11/10.18)	NQRPGQPM.........NMPG.MQN.KMP
  313-  337 (43.69/15.74)	NQMVASPALVPSPS...PQHAIMTG.PSR
  338-  364 (34.30/10.81)	S..VNSVGMAPSPSsslNTPGGVGAtPSP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     177.90|      41|      50|     430|     470|       3
---------------------------------------------------------------------------
  366-  401 (33.79/15.71)	...QEDQAYRDKVRQLSKY.........IE.PLrrmIA.KMS...S...EGNVD.KL
  402-  446 (44.55/22.76)	SKMKK......LLEILSTPskrmpldtlLKCEV..vLE.KLDFKRG...DGSVGPPV
  447-  491 (55.29/29.79)	TTLKEHQIFSPLLEAVSAH.........LQSPV..iNH.TLQRTFGpclDALFGPEI
  496-  531 (44.27/22.57)	APLKKHKIEEPSSE.IPDV.........LQGEI.....aRLD.QRF...KVSLDP..
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.93|      14|      16|     235|     250|       4
---------------------------------------------------------------------------
  235-  250 (26.33/18.48)	G.GPMGGIQasMPQQMN
  253-  267 (23.60/10.31)	GpGQLGPGQ..MQQQLN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.24|      13|      50|     104|     116|       5
---------------------------------------------------------------------------
   81-   93 (24.23/ 9.89)	AGSNNPGMQDPIG
  104-  116 (27.01/11.91)	GNNQMMGMGGPGP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP00230 with Med15 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MNSKKDAADNAPGAAGSNNPGMQDPIGALQTLARQGTGNNQMMGMGGPGPNHQGIIPQPTANTATNLLQSLNQRPGQPMNMPGMQNKMPGMNMMPAQAGGPMGHMGPIQTMQNNPMLTQMNQMGQGNIPQQMNQMVPGQMGQLAAGQMQPNMQSQMQNQLPNQINNQIGGPMGGIQASMPQQMNQIGPGQLGPGQMQQQLNHIQRKPAEMMNAGFPGPRNVTPNQFLRQSPSPSAPSPAGLGAPSSNQMVASPALVPSPSPQHAIMTGPSRSVNSVGMAPSPSSSLNTPGGVGATPSPQQEDQAYRDKVRQ
67
377










Molecular Recognition Features






MoRF SequenceStartStop




NANANA