<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP00214

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMSSGRRVTRPIRQLSLQQPTSRRLQIRRQRSTEDDYGKSLQIYANSVPRRKSATNVTETKKHVRVAWGKNDSKDSGRELAQVEVIAHQIPGRLKSATNRPSRSYVATESILYSRQELAERLRLAWKHREENKANIDIFLAHGMKERSNSELSISVPTTASSTKKSDYVQDDVSRGMEIPNFEVQKKELCKVDNKNKRECEEIINIAPQMMEESTDVISDIENEGGRQNEKAKDSRIDLDLEKKKKTCITLDCLHPSAIFSSLKSEDTNSAKLNDNFSMAKQKRASFHSKTNRAFLVPMMEKPSKEIAEAKDKIIPVKSVEIRCASAKTTINSPVDKCATLTKNSSITSLRKMRRTNSAPSQRENITARMQVNIVIDASGLTEATDKSINCRKMQNKKDIMDEDKEDLTKISQIERSIKSAPVKRKSKSAKRRFFTSLSPSRCKDEQNTERRKNSVDPRTSDVITMVSLISSADSDSDMENSSSDDKLIDELRNKLPTTPIIKTSINTSLNTARKPIKSVSFQRSSFEISTKEEKDVVNDVEPPTPLNSIINVTQKKEGNENLVKQDLVVNSTVVTSTLAAVSALITQDAENAMLEAPLNNREKRCLAVPIGELHDKKWKLLQAKSAPSYITVTEKMNNSPMEEVKEQKQHFTMSSINLVTNSSPPINSPTKCEKTTKMAPVPLEGHQTPVTNNIPQEGNRGGSISLGMLIDFIIQRTYHELTVLAELLPRKTDMERKIEIYNFSARTRQLYVRLLALVKWANSASKVDKSTHIMAFLDKQSLLFVDTADMLARMARETLVHARLPNFHIPAAVEVLTTGTYGRLPACIRERIVPPDPITTTEKRTTLQRLNQVIQHRLVTGNLLPQMRNLKIEAGRVTFLVEQEFSVSLTVMGDGGTVPWRLLELEILVSDRETGDGKALVHPLQTRYVHQVVQTRLAESTNPLSEVYHILHYFCQSLQLEVLYSQTLRLIRDRLDDHIHVDEYTRGKCLSISYWR
Length996
PositionTail
OrganismOoceraea biroi (Clonal raider ant) (Cerapachys biroi)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Hymenoptera> Apocrita> Aculeata> Formicoidea> Formicidae> Dorylinae> Ooceraea.
Aromaticity0.04
Grand average of hydropathy-0.597
Instability index49.32
Isoelectric point9.40
Molecular weight112696.46
Publications
PubMed=24508170

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU365082
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP00214
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     760.56|     271|     334|      26|     359|       1
---------------------------------------------------------------------------
   44-  359 (386.77/319.59)	AN.SVPRRKSATNVTE.TKKHV..RVAWGKNDSKDSGRE.LAQVEviahQIPGRLKSA.TNRPSRSyvATESILYS......RQElaerlrlawKHREENKANIDiflahgmkERSNSELS.ISVPTTASS......TKKSDYVQDDVsRGmEIPNFEVQKKELCKVDNKNKRECEEiINIAPQMMEEST....DVISDIENEGGRqnekakDSRIDLDLEKK.KKTCITLDCLHPSAI.......FSSLKSEDTNSAKLNdnfsmakqkrASFHSKTNRAFLVP..........................MMEKPSKEIAEAKDKiIPVKSVEIrCASAKTTINSPvDKCATLTKNSSIT.SLRKMRRTNSAP
  367-  695 (373.79/200.91)	ARmQVNIVIDASGLTEaTDKSIncRKMQNKKDIMDEDKEdLTKIS....QIERSIKSApVKRKSKS..AKRRFFTSlspsrcKDE.........QNTERRKNSVD........PRTSDVITmVSLISSADSdsdmenSSSDDKLIDEL.RN.KLPTTPIIKTSINTSLNTARKPIKS.VSFQRSSFEISTkeekDVVNDVEPPTPL......NSIINVTQKKEgNENLVKQDLVVNSTVvtstlaaVSALITQDAENAMLE..........APLNNREKRCLAVPigelhdkkwkllqaksapsyitvtekMNNSPMEEVKEQKQH.FTMSSINL.VTNSSPPINSP.TKCEKTTKMAPVPlEGHQTPVTNNIP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     267.68|      93|     175|     700|     799|       2
---------------------------------------------------------------------------
  700-  799 (137.13/119.36)	RGGSISLGMlIDFIIQRTYH.ELTVLAE..LLP.RKTDME..........RKIEIYNFSARtrqlYVRLLALVKWANSASKVDKSTHIMAFLdKQSL.LFVDTADMLaRMARETL
  868-  975 (130.55/91.08)	RNLKIEAGR.VTFLVEQEFSvSLTVMGDggTVPwRLLELEilvsdretgdGKALVHPLQTR....YVHQVVQTRLAESTNPLSEVYHILHYF.CQSLqLEVLYSQTL.RLIRDRL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.11|      15|      15|      12|      26|       3
---------------------------------------------------------------------------
   12-   26 (25.82/13.86)	RQLSLQQPTSRRLQI
   28-   42 (26.28/14.22)	RQRSTEDDYGKSLQI
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP00214 with Med14 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) DKSINCRKMQNKKDIMDEDKEDLTKISQIERSIKSAPVKRK
2) MSSGRRVTRPIRQLSLQQPTSRRLQIRRQRS
3) SAKRRFFTSLSPSRCKDEQNTERRKNSVDPRTSDVITMVSLISSADSDSDMENSSSDDKLIDELRN
4) SSPPINSPTKCEKTTKMAPVPLEGHQTPVTNNIPQEG
385
1
428
662
425
31
493
698










Molecular Recognition Features






MoRF SequenceStartStop




1) GRRVTRPIRQL
2) YGKSLQIY
4
36
14
43